Two- and Three-Dimensional Speckle Tracking Analysis of the Relation Between Myocardial Deformation and Functional Capacity in Patients With Systemic Hypertension
The purpose of this study was to investigate left ventricular (LV) mechanics in hypertensive patients by 2- and 3-dimensional (3D) speckle tracking imaging, and determine the relation between the LV mechanics and functional capacity in this population. This cross-sectional study included 51 recently...
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| Veröffentlicht in: | The American journal of cardiology 2014-03, Vol.113 (5), p.832-839 |
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| creator | Celic, Vera, MD, PhD Tadic, Marijana, MD, PhD Suzic-Lazic, Jelena, MD Andric, Anita, MD Majstorovic, Anka, MD Ivanovic, Branislava, MD, PhD Stevanovic, Predrag, MD, PhD Iracek, Olinka, RN Scepanovic, Radisav, MD, PhD |
| description | The purpose of this study was to investigate left ventricular (LV) mechanics in hypertensive patients by 2- and 3-dimensional (3D) speckle tracking imaging, and determine the relation between the LV mechanics and functional capacity in this population. This cross-sectional study included 51 recently diagnosed, untreated, hypertensive patients, 49 treated subjects with well-controlled arterial hypertension, 52 treated participants with uncontrolled hypertension, and 50 controls adjusted by gender and age. All the subjects underwent 24-hour blood pressure monitoring, complete 2-dimensional and 3D examination, and cardiopulmonary exercise testing. 3D global longitudinal, circumferential, radial, and area strains were similar between the control group and well-controlled hypertensive patients but significantly decreased in comparison with patients with untreated or inadequately controlled hypertension. Similar findings were obtained for LV torsion and twist rate, whereas LV untwisting rate significantly deteriorated from the controls, across the well-controlled group, to the patients with untreated or uncontrolled hypertension. Peak oxygen uptake was significantly lower in the patients with untreated and uncontrolled hypertension than in the controls and the well-treated hypertensive patients. Peak oxygen uptake was independently associated with LV untwisting rate (β = 0.28, p = 0.03), 3D LV ejection fraction (β = 0.31, p = 0.024), and 3D global longitudinal strain (β = 0.26, p = 0.037) in the whole hypertensive population in our study. In conclusion, LV mechanics and functional capacity are significantly impaired in the patients with uncontrolled and untreated hypertension in comparison with the controls and the well-controlled hypertensive patients. Functional capacity is independently associated with 3D global longitudinal strain, LV untwisting rate, and 3D LV ejection fraction. |
| doi_str_mv | 10.1016/j.amjcard.2013.11.031 |
| format | Article |
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This cross-sectional study included 51 recently diagnosed, untreated, hypertensive patients, 49 treated subjects with well-controlled arterial hypertension, 52 treated participants with uncontrolled hypertension, and 50 controls adjusted by gender and age. All the subjects underwent 24-hour blood pressure monitoring, complete 2-dimensional and 3D examination, and cardiopulmonary exercise testing. 3D global longitudinal, circumferential, radial, and area strains were similar between the control group and well-controlled hypertensive patients but significantly decreased in comparison with patients with untreated or inadequately controlled hypertension. Similar findings were obtained for LV torsion and twist rate, whereas LV untwisting rate significantly deteriorated from the controls, across the well-controlled group, to the patients with untreated or uncontrolled hypertension. Peak oxygen uptake was significantly lower in the patients with untreated and uncontrolled hypertension than in the controls and the well-treated hypertensive patients. Peak oxygen uptake was independently associated with LV untwisting rate (β = 0.28, p = 0.03), 3D LV ejection fraction (β = 0.31, p = 0.024), and 3D global longitudinal strain (β = 0.26, p = 0.037) in the whole hypertensive population in our study. In conclusion, LV mechanics and functional capacity are significantly impaired in the patients with uncontrolled and untreated hypertension in comparison with the controls and the well-controlled hypertensive patients. Functional capacity is independently associated with 3D global longitudinal strain, LV untwisting rate, and 3D LV ejection fraction.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2013.11.031</identifier><identifier>PMID: 24528615</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acquisitions & mergers ; Adult ; Body mass index ; Cardiovascular ; Cardiovascular disease ; Cross-Sectional Studies ; Deformation ; Drug therapy ; Echocardiography, Doppler - methods ; Echocardiography, Three-Dimensional - methods ; Exercise Test ; Female ; Flow velocity ; Heart ; Heart attacks ; Heart rate ; Humans ; Hypertension ; Hypertension - diagnostic imaging ; Hypertension - physiopathology ; Hypertrophy, Left Ventricular - physiopathology ; Image Interpretation, Computer-Assisted ; Male ; Mechanics ; Middle Aged ; Mortality ; Older people ; Oxygen Consumption ; Population ; Software ; Stroke Volume - physiology ; Studies ; Ventilation ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>The American journal of cardiology, 2014-03, Vol.113 (5), p.832-839</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Mar 1, 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-d4cebc5cd89c0ee8d9d8ca5d8b03497ec834a95c5bb13470d3f370b36cc53f903</citedby><cites>FETCH-LOGICAL-c448t-d4cebc5cd89c0ee8d9d8ca5d8b03497ec834a95c5bb13470d3f370b36cc53f903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000291491302376X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24528615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Celic, Vera, MD, PhD</creatorcontrib><creatorcontrib>Tadic, Marijana, MD, PhD</creatorcontrib><creatorcontrib>Suzic-Lazic, Jelena, MD</creatorcontrib><creatorcontrib>Andric, Anita, MD</creatorcontrib><creatorcontrib>Majstorovic, Anka, MD</creatorcontrib><creatorcontrib>Ivanovic, Branislava, MD, PhD</creatorcontrib><creatorcontrib>Stevanovic, Predrag, MD, PhD</creatorcontrib><creatorcontrib>Iracek, Olinka, RN</creatorcontrib><creatorcontrib>Scepanovic, Radisav, MD, PhD</creatorcontrib><title>Two- and Three-Dimensional Speckle Tracking Analysis of the Relation Between Myocardial Deformation and Functional Capacity in Patients With Systemic Hypertension</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The purpose of this study was to investigate left ventricular (LV) mechanics in hypertensive patients by 2- and 3-dimensional (3D) speckle tracking imaging, and determine the relation between the LV mechanics and functional capacity in this population. This cross-sectional study included 51 recently diagnosed, untreated, hypertensive patients, 49 treated subjects with well-controlled arterial hypertension, 52 treated participants with uncontrolled hypertension, and 50 controls adjusted by gender and age. All the subjects underwent 24-hour blood pressure monitoring, complete 2-dimensional and 3D examination, and cardiopulmonary exercise testing. 3D global longitudinal, circumferential, radial, and area strains were similar between the control group and well-controlled hypertensive patients but significantly decreased in comparison with patients with untreated or inadequately controlled hypertension. Similar findings were obtained for LV torsion and twist rate, whereas LV untwisting rate significantly deteriorated from the controls, across the well-controlled group, to the patients with untreated or uncontrolled hypertension. Peak oxygen uptake was significantly lower in the patients with untreated and uncontrolled hypertension than in the controls and the well-treated hypertensive patients. Peak oxygen uptake was independently associated with LV untwisting rate (β = 0.28, p = 0.03), 3D LV ejection fraction (β = 0.31, p = 0.024), and 3D global longitudinal strain (β = 0.26, p = 0.037) in the whole hypertensive population in our study. In conclusion, LV mechanics and functional capacity are significantly impaired in the patients with uncontrolled and untreated hypertension in comparison with the controls and the well-controlled hypertensive patients. Functional capacity is independently associated with 3D global longitudinal strain, LV untwisting rate, and 3D LV ejection fraction.</description><subject>Acquisitions & mergers</subject><subject>Adult</subject><subject>Body mass index</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Cross-Sectional Studies</subject><subject>Deformation</subject><subject>Drug therapy</subject><subject>Echocardiography, Doppler - methods</subject><subject>Echocardiography, Three-Dimensional - methods</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Flow velocity</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart rate</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - diagnostic imaging</subject><subject>Hypertension - physiopathology</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Male</subject><subject>Mechanics</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Older people</subject><subject>Oxygen Consumption</subject><subject>Population</subject><subject>Software</subject><subject>Stroke Volume - 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methods</topic><topic>Echocardiography, Three-Dimensional - methods</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Flow velocity</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart rate</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - diagnostic imaging</topic><topic>Hypertension - physiopathology</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Male</topic><topic>Mechanics</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Older people</topic><topic>Oxygen Consumption</topic><topic>Population</topic><topic>Software</topic><topic>Stroke Volume - physiology</topic><topic>Studies</topic><topic>Ventilation</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Celic, Vera, MD, PhD</creatorcontrib><creatorcontrib>Tadic, Marijana, MD, PhD</creatorcontrib><creatorcontrib>Suzic-Lazic, Jelena, MD</creatorcontrib><creatorcontrib>Andric, Anita, MD</creatorcontrib><creatorcontrib>Majstorovic, Anka, MD</creatorcontrib><creatorcontrib>Ivanovic, Branislava, MD, PhD</creatorcontrib><creatorcontrib>Stevanovic, Predrag, MD, PhD</creatorcontrib><creatorcontrib>Iracek, Olinka, RN</creatorcontrib><creatorcontrib>Scepanovic, Radisav, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Celic, Vera, MD, PhD</au><au>Tadic, Marijana, MD, PhD</au><au>Suzic-Lazic, Jelena, MD</au><au>Andric, Anita, MD</au><au>Majstorovic, Anka, MD</au><au>Ivanovic, Branislava, MD, PhD</au><au>Stevanovic, Predrag, MD, PhD</au><au>Iracek, Olinka, RN</au><au>Scepanovic, Radisav, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two- and Three-Dimensional Speckle Tracking Analysis of the Relation Between Myocardial Deformation and Functional Capacity in Patients With Systemic Hypertension</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>113</volume><issue>5</issue><spage>832</spage><epage>839</epage><pages>832-839</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>The purpose of this study was to investigate left ventricular (LV) mechanics in hypertensive patients by 2- and 3-dimensional (3D) speckle tracking imaging, and determine the relation between the LV mechanics and functional capacity in this population. This cross-sectional study included 51 recently diagnosed, untreated, hypertensive patients, 49 treated subjects with well-controlled arterial hypertension, 52 treated participants with uncontrolled hypertension, and 50 controls adjusted by gender and age. All the subjects underwent 24-hour blood pressure monitoring, complete 2-dimensional and 3D examination, and cardiopulmonary exercise testing. 3D global longitudinal, circumferential, radial, and area strains were similar between the control group and well-controlled hypertensive patients but significantly decreased in comparison with patients with untreated or inadequately controlled hypertension. Similar findings were obtained for LV torsion and twist rate, whereas LV untwisting rate significantly deteriorated from the controls, across the well-controlled group, to the patients with untreated or uncontrolled hypertension. Peak oxygen uptake was significantly lower in the patients with untreated and uncontrolled hypertension than in the controls and the well-treated hypertensive patients. Peak oxygen uptake was independently associated with LV untwisting rate (β = 0.28, p = 0.03), 3D LV ejection fraction (β = 0.31, p = 0.024), and 3D global longitudinal strain (β = 0.26, p = 0.037) in the whole hypertensive population in our study. In conclusion, LV mechanics and functional capacity are significantly impaired in the patients with uncontrolled and untreated hypertension in comparison with the controls and the well-controlled hypertensive patients. Functional capacity is independently associated with 3D global longitudinal strain, LV untwisting rate, and 3D LV ejection fraction.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24528615</pmid><doi>10.1016/j.amjcard.2013.11.031</doi><tpages>8</tpages></addata></record> |
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| subjects | Acquisitions & mergers Adult Body mass index Cardiovascular Cardiovascular disease Cross-Sectional Studies Deformation Drug therapy Echocardiography, Doppler - methods Echocardiography, Three-Dimensional - methods Exercise Test Female Flow velocity Heart Heart attacks Heart rate Humans Hypertension Hypertension - diagnostic imaging Hypertension - physiopathology Hypertrophy, Left Ventricular - physiopathology Image Interpretation, Computer-Assisted Male Mechanics Middle Aged Mortality Older people Oxygen Consumption Population Software Stroke Volume - physiology Studies Ventilation Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - physiopathology |
| title | Two- and Three-Dimensional Speckle Tracking Analysis of the Relation Between Myocardial Deformation and Functional Capacity in Patients With Systemic Hypertension |
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