Key role of endothelial importin-α in VEGF expression and gastric angiogenesis: novel insight into aging gastropathy

Recent in vivo studies demonstrated that aging gastric mucosa has impaired angiogenesis and reduced expression of vascular endothelial growth factor (VEGF). Angiogenesis is triggered by hypoxia and VEGF gene activation, and the latter requires transport of transcription factor(s) into endothelial ce...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2014-02, Vol.306 (4), p.G338-G345
Hauptverfasser:	Ahluwalia, Amrita, Jones, Michael K, Tarnawski, Andrzej S
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Age Factors Aging - metabolism alpha Karyopherins - genetics alpha Karyopherins - metabolism Animals Binding Sites Cells, Cultured Endothelial Cells - metabolism Endothelial Cells - pathology Gastric Mucosa - blood supply Gene Expression Regulation Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Neovascularization, Physiologic Promoter Regions, Genetic Rats Rats, Inbred F344 RNA Interference Signal Transduction Stomach Diseases - genetics Stomach Diseases - metabolism Stomach Diseases - pathology Transfection Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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