Induction of the Endoplasmic Reticulum Stress and Autophagy in Human Lung Carcinoma A549 Cells by Anacardic Acid

Anacardic acid (AA, 2-hydroxy-6-pentadecylbenzoic acid), a constituent of the cashew-nut shell, has a variety of beneficial effects on the treatment of cancer and tumors. However, the fact that AA induces ER stress and autophagy in cancer cell is not known. We investigated the effect of AA on ER-str...

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Veröffentlicht in:	Cell biochemistry and biophysics 2014-03, Vol.68 (2), p.369-377
Hauptverfasser:	Seong, Yeong-Ae, Shin, Pyung-Gyun, Yoon, Jin-Soo, Yadunandam, Anandam Kasin, Kim, Gun-Do
Format:	Artikel
Sprache:	eng
Schlagworte:	Anacardic Acids - pharmacology Antineoplastic Agents - pharmacology Autophagy - drug effects Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biotechnology Calcium - metabolism Cell Biology Cell Line, Tumor Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - pathology Endoplasmic Reticulum Stress - drug effects Endoribonucleases - metabolism Eukaryotic Initiation Factor-2 - metabolism Heat-Shock Proteins - metabolism HEK293 Cells Humans Life Sciences Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Original Paper Pharmacology/Toxicology Phosphorylation - drug effects Protein-Serine-Threonine Kinases - metabolism Transcription Factor CHOP - metabolism Up-Regulation - drug effects
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