MCP-1and IL-1β expression in the myocardia of two young patients with Type 1 diabetes mellitus and fatal diabetic ketoacidosis

Convincing evidence exists for the early onset of diabetic cardiomyopathy and coronary artery disease (CAD) as distinct forms of cardiac disease in young patients with Type 1 diabetes mellitus (T1DM) and the pre-stages of T2DM, forms of dysregulated insulin signaling. Progression of both chronic car...

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Veröffentlicht in:	Experimental and molecular pathology 2014-02, Vol.96 (1), p.71-79
Hauptverfasser:	Niu, Jianli, Gilliland, M.G.F., Jin, Zhuqing, Kolattukudy, Pappachan E., Hoffman, William H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Apoptosis Chemokine CCL2 - metabolism Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - pathology Diabetic cardiomyopathy Diabetic ketoacidosis Diabetic Ketoacidosis - complications Diabetic Ketoacidosis - metabolism Diabetic Ketoacidosis - pathology Fatal Outcome Humans Hypertrophy - etiology Hypertrophy - metabolism Hypertrophy - pathology IL-1β Immunoenzyme Techniques In Situ Nick-End Labeling Inflammation - etiology Inflammation - metabolism Inflammation - pathology Interleukin-1beta - metabolism Male MCP-1 Myocardium - metabolism Myocardium - pathology Obesity Oxidative Stress Type 1 diabetes mellitus Young Adult
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