A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids

This study reports on a microfluidic platform on which single multicellular spheroids from malignant pleural mesothelioma (MPM), an aggressive tumor with poor prognosis, can be loaded, trapped and tested for chemotherapeutic drug response. A new method to detect the spheroid viability cultured on th...

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Veröffentlicht in:	Lab on a chip 2014-03, Vol.14 (6), p.1198-1205
Hauptverfasser:	Ruppen, Janine, Cortes-Dericks, Lourdes, Marconi, Emanuele, Karoubi, Golnaz, Schmid, Ralph A, Peng, Renwang, Marti, Thomas M, Guenat, Olivier T
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Drug Screening Assays, Antitumor - instrumentation Drug Screening Assays, Antitumor - methods Humans Mesothelioma - metabolism Mesothelioma - pathology Microfluidic Analytical Techniques - instrumentation Microfluidic Analytical Techniques - methods Pleural Neoplasms - metabolism Pleural Neoplasms - pathology Spheroids, Cellular - metabolism
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