Clinical courses and outcomes of hospitalized adult patients with seasonal influenza in Korea, 2011–2012: Hospital-based Influenza Morbidity & Mortality (HIMM) surveillance
Abstract Influenza is an acute respiratory illness, which can be accompanied by complications such as pneumonia. This study was conducted to survey the clinical courses and outcomes of hospitalized adult patients with laboratory-confirmed seasonal influenza. A prospective case–control study was perf...
Gespeichert in:
| Veröffentlicht in: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2014, Vol.20 (1), p.9-14 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 14 |
|---|---|
| container_issue | 1 |
| container_start_page | 9 |
| container_title | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy |
| container_volume | 20 |
| creator | Hong, Kyung-Wook Cheong, Hee Jin Choi, Won Suk Lee, Jacob Wie, Seong-Heon Baek, Ji Hyeon Kim, Hyo Youl Jeong, Hye Won Kim, Woo Joo |
| description | Abstract Influenza is an acute respiratory illness, which can be accompanied by complications such as pneumonia. This study was conducted to survey the clinical courses and outcomes of hospitalized adult patients with laboratory-confirmed seasonal influenza. A prospective case–control study was performed in adult influenza patients who were admitted to hospitals participating in the Hospital-based Influenza Morbidity and Mortality (HIMM) surveillance system in Korea from October 2011 to May 2012. Cases with complicated influenza were compared to those without complications. A total of 123 (5.6%) patients among 2184 laboratory-confirmed adult influenza patients were hospitalized during the 2011–2012 influenza epidemic season. Forty (32.5%) experienced 50 complication episodes. Age older than 60 years ( P |
| doi_str_mv | 10.1016/j.jiac.2013.07.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1499149169</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1341321X13000056</els_id><sourcerecordid>1499149169</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-490e8cdcb904d74cd7eab6d0773bc9939e08b156711ad38a755184861cdbcdca3</originalsourceid><addsrcrecordid>eNp9UsGKFDEQbURx19Uf8CA5yQp2m3TSne5FBBnUGdzBgwreQjqpYdP2dMYkvTJ78h_8Dz_KL7GaGffgwUBRL_DqpSqvsuwxowWjrH7RF73Tpigp4wWVBaXsTnbKBJe5lA29i5gLlvOSfTnJHsTYI0FWTXM_OymFqDGq0-zXYnCjM3ogxk8hQiR6tMRPyfgtXvyGXPm4c0kP7gYs0XYaEtnp5GBMkXx36YpE0NGPqODGzTDBeKMRkfc-gH5OsDn2-8dPTOUFWR6l8k5HFFvd8tc-dM66tCdPZzy_hvh8uVqvn5E4hWtww6BHAw-zexs9RHh0zGfZ57dvPi2W-eWHd6vF68vciJKmXLQUGmNN11JhpTBWgu5qS6XknWlb3gJtOlbVkjFteaNlVbFGNDUztsMyzc-y84PuLvhvE8Skti4amJsAP0XFRNtisLpFanmgmuBjDLBRu-C2OuwVo2r2SfVq9knNPikqFdqARU-O-lO3BXtb8tcYJLw8EACnvHYQVDT45wasC2CSst79X__VP-Xm6PNX2EPs0Wt0DOdQsVRUfZw3ZV4UximequZ_ADquu4k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1499149169</pqid></control><display><type>article</type><title>Clinical courses and outcomes of hospitalized adult patients with seasonal influenza in Korea, 2011–2012: Hospital-based Influenza Morbidity & Mortality (HIMM) surveillance</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Hong, Kyung-Wook ; Cheong, Hee Jin ; Choi, Won Suk ; Lee, Jacob ; Wie, Seong-Heon ; Baek, Ji Hyeon ; Kim, Hyo Youl ; Jeong, Hye Won ; Kim, Woo Joo</creator><creatorcontrib>Hong, Kyung-Wook ; Cheong, Hee Jin ; Choi, Won Suk ; Lee, Jacob ; Wie, Seong-Heon ; Baek, Ji Hyeon ; Kim, Hyo Youl ; Jeong, Hye Won ; Kim, Woo Joo</creatorcontrib><description>Abstract Influenza is an acute respiratory illness, which can be accompanied by complications such as pneumonia. This study was conducted to survey the clinical courses and outcomes of hospitalized adult patients with laboratory-confirmed seasonal influenza. A prospective case–control study was performed in adult influenza patients who were admitted to hospitals participating in the Hospital-based Influenza Morbidity and Mortality (HIMM) surveillance system in Korea from October 2011 to May 2012. Cases with complicated influenza were compared to those without complications. A total of 123 (5.6%) patients among 2184 laboratory-confirmed adult influenza patients were hospitalized during the 2011–2012 influenza epidemic season. Forty (32.5%) experienced 50 complication episodes. Age older than 60 years ( P < 0.01), male sex ( P = 0.04), diabetes ( P < 0.01), chronic cardiovascular disease ( P < 0.01) and neuromuscular disease ( P = 0.02) were significantly related to development of complications in univariate analysis. Multivariate logistic regression analysis revealed that diabetes (odds ratio [OR] 3.63, 95% confidence interval [CI] 1.15–11.51, P = 0.02) was an independent risk factor for complicated seasonal influenza. C-reactive protein (CRP) was discriminative between complicated and uncomplicated influenza (cutoff value 13 mg/L, sensitivity 70%, specificity 74%). Complicated patients received antibiotics more frequently ( P < 0.01) with longer hospital stays ( P = 0.01). In conclusion, diabetic patients are at great risk for complicated influenza, and CRP would be useful to predicting complication. Therefore, early interventions such as antiviral therapy should be considered for high risk patients with diabetes, especially those with increased serum CRP level.</description><identifier>ISSN: 1341-321X</identifier><identifier>EISSN: 1437-7780</identifier><identifier>DOI: 10.1016/j.jiac.2013.07.001</identifier><identifier>PMID: 24462445</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; C-Reactive Protein - metabolism ; Case-Control Studies ; Complications ; Female ; Hematology, Oncology and Palliative Medicine ; Hospital Mortality ; Hospitalization - statistics & numerical data ; Hospitalized ; Hospitals ; Humans ; Influenza ; Influenza A Virus, H1N1 Subtype ; Influenza, Human - drug therapy ; Influenza, Human - metabolism ; Influenza, Human - mortality ; Influenza, Human - virology ; Male ; Middle Aged ; Prospective Studies ; Republic of Korea - epidemiology ; Risk Factors ; Seasons</subject><ispartof>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2014, Vol.20 (1), p.9-14</ispartof><rights>2013</rights><rights>Copyright © 2013. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-490e8cdcb904d74cd7eab6d0773bc9939e08b156711ad38a755184861cdbcdca3</citedby><cites>FETCH-LOGICAL-c420t-490e8cdcb904d74cd7eab6d0773bc9939e08b156711ad38a755184861cdbcdca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24462445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hong, Kyung-Wook</creatorcontrib><creatorcontrib>Cheong, Hee Jin</creatorcontrib><creatorcontrib>Choi, Won Suk</creatorcontrib><creatorcontrib>Lee, Jacob</creatorcontrib><creatorcontrib>Wie, Seong-Heon</creatorcontrib><creatorcontrib>Baek, Ji Hyeon</creatorcontrib><creatorcontrib>Kim, Hyo Youl</creatorcontrib><creatorcontrib>Jeong, Hye Won</creatorcontrib><creatorcontrib>Kim, Woo Joo</creatorcontrib><title>Clinical courses and outcomes of hospitalized adult patients with seasonal influenza in Korea, 2011–2012: Hospital-based Influenza Morbidity & Mortality (HIMM) surveillance</title><title>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</title><addtitle>J Infect Chemother</addtitle><description>Abstract Influenza is an acute respiratory illness, which can be accompanied by complications such as pneumonia. This study was conducted to survey the clinical courses and outcomes of hospitalized adult patients with laboratory-confirmed seasonal influenza. A prospective case–control study was performed in adult influenza patients who were admitted to hospitals participating in the Hospital-based Influenza Morbidity and Mortality (HIMM) surveillance system in Korea from October 2011 to May 2012. Cases with complicated influenza were compared to those without complications. A total of 123 (5.6%) patients among 2184 laboratory-confirmed adult influenza patients were hospitalized during the 2011–2012 influenza epidemic season. Forty (32.5%) experienced 50 complication episodes. Age older than 60 years ( P < 0.01), male sex ( P = 0.04), diabetes ( P < 0.01), chronic cardiovascular disease ( P < 0.01) and neuromuscular disease ( P = 0.02) were significantly related to development of complications in univariate analysis. Multivariate logistic regression analysis revealed that diabetes (odds ratio [OR] 3.63, 95% confidence interval [CI] 1.15–11.51, P = 0.02) was an independent risk factor for complicated seasonal influenza. C-reactive protein (CRP) was discriminative between complicated and uncomplicated influenza (cutoff value 13 mg/L, sensitivity 70%, specificity 74%). Complicated patients received antibiotics more frequently ( P < 0.01) with longer hospital stays ( P = 0.01). In conclusion, diabetic patients are at great risk for complicated influenza, and CRP would be useful to predicting complication. Therefore, early interventions such as antiviral therapy should be considered for high risk patients with diabetes, especially those with increased serum CRP level.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>C-Reactive Protein - metabolism</subject><subject>Case-Control Studies</subject><subject>Complications</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hospital Mortality</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Hospitalized</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Influenza</subject><subject>Influenza A Virus, H1N1 Subtype</subject><subject>Influenza, Human - drug therapy</subject><subject>Influenza, Human - metabolism</subject><subject>Influenza, Human - mortality</subject><subject>Influenza, Human - virology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Republic of Korea - epidemiology</subject><subject>Risk Factors</subject><subject>Seasons</subject><issn>1341-321X</issn><issn>1437-7780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UsGKFDEQbURx19Uf8CA5yQp2m3TSne5FBBnUGdzBgwreQjqpYdP2dMYkvTJ78h_8Dz_KL7GaGffgwUBRL_DqpSqvsuwxowWjrH7RF73Tpigp4wWVBaXsTnbKBJe5lA29i5gLlvOSfTnJHsTYI0FWTXM_OymFqDGq0-zXYnCjM3ogxk8hQiR6tMRPyfgtXvyGXPm4c0kP7gYs0XYaEtnp5GBMkXx36YpE0NGPqODGzTDBeKMRkfc-gH5OsDn2-8dPTOUFWR6l8k5HFFvd8tc-dM66tCdPZzy_hvh8uVqvn5E4hWtww6BHAw-zexs9RHh0zGfZ57dvPi2W-eWHd6vF68vciJKmXLQUGmNN11JhpTBWgu5qS6XknWlb3gJtOlbVkjFteaNlVbFGNDUztsMyzc-y84PuLvhvE8Skti4amJsAP0XFRNtisLpFanmgmuBjDLBRu-C2OuwVo2r2SfVq9knNPikqFdqARU-O-lO3BXtb8tcYJLw8EACnvHYQVDT45wasC2CSst79X__VP-Xm6PNX2EPs0Wt0DOdQsVRUfZw3ZV4UximequZ_ADquu4k</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Hong, Kyung-Wook</creator><creator>Cheong, Hee Jin</creator><creator>Choi, Won Suk</creator><creator>Lee, Jacob</creator><creator>Wie, Seong-Heon</creator><creator>Baek, Ji Hyeon</creator><creator>Kim, Hyo Youl</creator><creator>Jeong, Hye Won</creator><creator>Kim, Woo Joo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Clinical courses and outcomes of hospitalized adult patients with seasonal influenza in Korea, 2011–2012: Hospital-based Influenza Morbidity & Mortality (HIMM) surveillance</title><author>Hong, Kyung-Wook ; Cheong, Hee Jin ; Choi, Won Suk ; Lee, Jacob ; Wie, Seong-Heon ; Baek, Ji Hyeon ; Kim, Hyo Youl ; Jeong, Hye Won ; Kim, Woo Joo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-490e8cdcb904d74cd7eab6d0773bc9939e08b156711ad38a755184861cdbcdca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>C-Reactive Protein - metabolism</topic><topic>Case-Control Studies</topic><topic>Complications</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hospital Mortality</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Hospitalized</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Influenza</topic><topic>Influenza A Virus, H1N1 Subtype</topic><topic>Influenza, Human - drug therapy</topic><topic>Influenza, Human - metabolism</topic><topic>Influenza, Human - mortality</topic><topic>Influenza, Human - virology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Republic of Korea - epidemiology</topic><topic>Risk Factors</topic><topic>Seasons</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, Kyung-Wook</creatorcontrib><creatorcontrib>Cheong, Hee Jin</creatorcontrib><creatorcontrib>Choi, Won Suk</creatorcontrib><creatorcontrib>Lee, Jacob</creatorcontrib><creatorcontrib>Wie, Seong-Heon</creatorcontrib><creatorcontrib>Baek, Ji Hyeon</creatorcontrib><creatorcontrib>Kim, Hyo Youl</creatorcontrib><creatorcontrib>Jeong, Hye Won</creatorcontrib><creatorcontrib>Kim, Woo Joo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Kyung-Wook</au><au>Cheong, Hee Jin</au><au>Choi, Won Suk</au><au>Lee, Jacob</au><au>Wie, Seong-Heon</au><au>Baek, Ji Hyeon</au><au>Kim, Hyo Youl</au><au>Jeong, Hye Won</au><au>Kim, Woo Joo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical courses and outcomes of hospitalized adult patients with seasonal influenza in Korea, 2011–2012: Hospital-based Influenza Morbidity & Mortality (HIMM) surveillance</atitle><jtitle>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</jtitle><addtitle>J Infect Chemother</addtitle><date>2014</date><risdate>2014</risdate><volume>20</volume><issue>1</issue><spage>9</spage><epage>14</epage><pages>9-14</pages><issn>1341-321X</issn><eissn>1437-7780</eissn><abstract>Abstract Influenza is an acute respiratory illness, which can be accompanied by complications such as pneumonia. This study was conducted to survey the clinical courses and outcomes of hospitalized adult patients with laboratory-confirmed seasonal influenza. A prospective case–control study was performed in adult influenza patients who were admitted to hospitals participating in the Hospital-based Influenza Morbidity and Mortality (HIMM) surveillance system in Korea from October 2011 to May 2012. Cases with complicated influenza were compared to those without complications. A total of 123 (5.6%) patients among 2184 laboratory-confirmed adult influenza patients were hospitalized during the 2011–2012 influenza epidemic season. Forty (32.5%) experienced 50 complication episodes. Age older than 60 years ( P < 0.01), male sex ( P = 0.04), diabetes ( P < 0.01), chronic cardiovascular disease ( P < 0.01) and neuromuscular disease ( P = 0.02) were significantly related to development of complications in univariate analysis. Multivariate logistic regression analysis revealed that diabetes (odds ratio [OR] 3.63, 95% confidence interval [CI] 1.15–11.51, P = 0.02) was an independent risk factor for complicated seasonal influenza. C-reactive protein (CRP) was discriminative between complicated and uncomplicated influenza (cutoff value 13 mg/L, sensitivity 70%, specificity 74%). Complicated patients received antibiotics more frequently ( P < 0.01) with longer hospital stays ( P = 0.01). In conclusion, diabetic patients are at great risk for complicated influenza, and CRP would be useful to predicting complication. Therefore, early interventions such as antiviral therapy should be considered for high risk patients with diabetes, especially those with increased serum CRP level.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>24462445</pmid><doi>10.1016/j.jiac.2013.07.001</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1341-321X |
| ispartof | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2014, Vol.20 (1), p.9-14 |
| issn | 1341-321X 1437-7780 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1499149169 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over C-Reactive Protein - metabolism Case-Control Studies Complications Female Hematology, Oncology and Palliative Medicine Hospital Mortality Hospitalization - statistics & numerical data Hospitalized Hospitals Humans Influenza Influenza A Virus, H1N1 Subtype Influenza, Human - drug therapy Influenza, Human - metabolism Influenza, Human - mortality Influenza, Human - virology Male Middle Aged Prospective Studies Republic of Korea - epidemiology Risk Factors Seasons |
| title | Clinical courses and outcomes of hospitalized adult patients with seasonal influenza in Korea, 2011–2012: Hospital-based Influenza Morbidity & Mortality (HIMM) surveillance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T21%3A49%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20courses%20and%20outcomes%20of%20hospitalized%20adult%20patients%20with%20seasonal%20influenza%20in%20Korea,%202011%E2%80%932012:%20Hospital-based%20Influenza%20Morbidity%20&%20Mortality%20(HIMM)%20surveillance&rft.jtitle=Journal%20of%20infection%20and%20chemotherapy%20:%20official%20journal%20of%20the%20Japan%20Society%20of%20Chemotherapy&rft.au=Hong,%20Kyung-Wook&rft.date=2014&rft.volume=20&rft.issue=1&rft.spage=9&rft.epage=14&rft.pages=9-14&rft.issn=1341-321X&rft.eissn=1437-7780&rft_id=info:doi/10.1016/j.jiac.2013.07.001&rft_dat=%3Cproquest_cross%3E1499149169%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1499149169&rft_id=info:pmid/24462445&rft_els_id=S1341321X13000056&rfr_iscdi=true |