Occurrence of protein disulfide bonds in different domains of life: a comparison of proteins from the Protein Data Bank

Disulfide bonds (SS bonds) are important post-translational modifications of proteins. They stabilize a three-dimensional (3D) structure (structural SS bonds) and also have the catalytic or regulatory functions (redox-active SS bonds). Although SS bonds are present in all groups of organisms, no com...

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Veröffentlicht in:Protein engineering, design and selection design and selection, 2014-03, Vol.27 (3), p.65-72
Hauptverfasser: Bošnjak, I., Bojović, V., Šegvić-Bubić, T., Bielen, A.
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container_end_page 72
container_issue 3
container_start_page 65
container_title Protein engineering, design and selection
container_volume 27
creator Bošnjak, I.
Bojović, V.
Šegvić-Bubić, T.
Bielen, A.
description Disulfide bonds (SS bonds) are important post-translational modifications of proteins. They stabilize a three-dimensional (3D) structure (structural SS bonds) and also have the catalytic or regulatory functions (redox-active SS bonds). Although SS bonds are present in all groups of organisms, no comparative analyses of their frequency in proteins from different domains of life have been made to date. Using the Protein Data Bank, the number and subcellular locations of SS bonds in Archaea, Bacteria and Eukarya have been compared. Approximately three times higher frequency of proteins with SS bonds in eukaryotic secretory organelles (e.g. endoplasmic reticulum) than in bacterial periplasmic/secretory pathways was calculated. Protein length also affects the SS bond frequency: the average number of SS bonds is positively correlated with the length for longer proteins (>200 amino acids), while for the shorter and less stable proteins (
doi_str_mv 10.1093/protein/gzt063
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
subjects Amino Acid Sequence
Animals
Archaea
Bacteria
Databases, Protein
Disulfides - chemistry
Intracellular Space - chemistry
Proteins - chemistry
Proteins - genetics
title Occurrence of protein disulfide bonds in different domains of life: a comparison of proteins from the Protein Data Bank
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