Evaluation of gadolinium-EOB-DTPA uptake after portal vein embolization: value of an increased flip angle
Background The optimal sequence for Gd-EOB-DTPA uptake measurement in the liver with the purpose of liver function measurement is still not defined. Purpose To prospectively evaluate the effect of an increased flip angle (FA) of a T1-weighted fat-saturated 3D sequence for the measurement of hepatocy...
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| Veröffentlicht in: | Acta radiologica (1987) 2014-03, Vol.55 (2), p.149-154 |
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| container_title | Acta radiologica (1987) |
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| creator | Geisel, Dominik Lüdemann, Lutz Wagner, Clemens Stelter, Lars Grieser, Christian Malinowski, Maciej Stockmann, Martin Seehofer, Daniel Hamm, Bernd Gebauer, Bernhard Denecke, Timm |
| description | Background
The optimal sequence for Gd-EOB-DTPA uptake measurement in the liver with the purpose of liver function measurement is still not defined.
Purpose
To prospectively evaluate the effect of an increased flip angle (FA) of a T1-weighted fat-saturated 3D sequence for the measurement of hepatocyte uptake of Gd-EOB-DTPA magnetic resonance imaging (MRI) after right portal vein embolization (PVE).
Material and Methods
Ten patients who received a PVE prior to an extended hemihepatectomy were examined 14 days after PVE using Gd-EOB-DTPA enhanced MRI of the liver using the standard FA of 10° and the increased FA of 30°.
Results
Relative enhancement of the right liver lobe (RLL) was 0.52 ± 0.12 for 10° and 1.41 ± 0.39 for 30°. Relative enhancement of the left liver lobe (LLL) was 0.58 ± 0.11 for 10° and 2.05 ± 0.61 for 30°. Relative enhancement of the RLL was significantly higher for 30° than for 10° (P = 0.009) and significantly higher in the 30° than in the 10° sequences (P = 0.005) for the LLL.
Conclusion
A flip angle of 30° increases the contrast between liver partitions with and without portal venous embolization. Thereby, the sensitivity for differences in uptake intensity is increased. This could be of value for a more exact determination of differences in regional liver function and, consequently, the estimation of the future remnant liver function. |
| doi_str_mv | 10.1177/0284185113495833 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1499148106</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0284185113495833</sage_id><sourcerecordid>1499148106</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-b75d41c9a36159312aec0df472579a6a65389e0b4efe8a75d530447468def1ed3</originalsourceid><addsrcrecordid>eNp1kD1PwzAQhi0EoqWwMyGPLAFfbOeDrZTyIVUqQ5mja3KpXPKFnVSCX09CgQGJ6aS7532kexk7B3EFEIbXwo8URBpAqlhHUh6wMQRCeEJpfcjGw9kb7iN24txWCPBDDcds5MtYRL5SY2bmOyw6bE1d8TrnG8zqwlSmK7358ta7Wz1Pede0-Eoc85Ysb2rbYsF3ZCpO5bqHP77CN3zw0ODAipsqtYSOMp4Xpuk3m4JO2VGOhaOz7zlhL_fz1ezRWywfnmbThZcqIVtvHepMQRqjDEDHEnykVGS5Cn0dxhhgoGUUk1gryinCHtZSKBWqIMooB8rkhF3uvY2t3zpybVIal1JRYEV15xJQcQwqAhH0qNijqa2ds5QnjTUl2vcERDIUnPwtuI9cfNu7dUnZb-Cn0R7w9oDDDSXburNV_-3_wk9xXII7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1499148106</pqid></control><display><type>article</type><title>Evaluation of gadolinium-EOB-DTPA uptake after portal vein embolization: value of an increased flip angle</title><source>MEDLINE</source><source>SAGE Complete</source><creator>Geisel, Dominik ; Lüdemann, Lutz ; Wagner, Clemens ; Stelter, Lars ; Grieser, Christian ; Malinowski, Maciej ; Stockmann, Martin ; Seehofer, Daniel ; Hamm, Bernd ; Gebauer, Bernhard ; Denecke, Timm</creator><creatorcontrib>Geisel, Dominik ; Lüdemann, Lutz ; Wagner, Clemens ; Stelter, Lars ; Grieser, Christian ; Malinowski, Maciej ; Stockmann, Martin ; Seehofer, Daniel ; Hamm, Bernd ; Gebauer, Bernhard ; Denecke, Timm</creatorcontrib><description>Background
The optimal sequence for Gd-EOB-DTPA uptake measurement in the liver with the purpose of liver function measurement is still not defined.
Purpose
To prospectively evaluate the effect of an increased flip angle (FA) of a T1-weighted fat-saturated 3D sequence for the measurement of hepatocyte uptake of Gd-EOB-DTPA magnetic resonance imaging (MRI) after right portal vein embolization (PVE).
Material and Methods
Ten patients who received a PVE prior to an extended hemihepatectomy were examined 14 days after PVE using Gd-EOB-DTPA enhanced MRI of the liver using the standard FA of 10° and the increased FA of 30°.
Results
Relative enhancement of the right liver lobe (RLL) was 0.52 ± 0.12 for 10° and 1.41 ± 0.39 for 30°. Relative enhancement of the left liver lobe (LLL) was 0.58 ± 0.11 for 10° and 2.05 ± 0.61 for 30°. Relative enhancement of the RLL was significantly higher for 30° than for 10° (P = 0.009) and significantly higher in the 30° than in the 10° sequences (P = 0.005) for the LLL.
Conclusion
A flip angle of 30° increases the contrast between liver partitions with and without portal venous embolization. Thereby, the sensitivity for differences in uptake intensity is increased. This could be of value for a more exact determination of differences in regional liver function and, consequently, the estimation of the future remnant liver function.</description><identifier>ISSN: 0284-1851</identifier><identifier>EISSN: 1600-0455</identifier><identifier>DOI: 10.1177/0284185113495833</identifier><identifier>PMID: 23908244</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Cholangiocarcinoma - diagnosis ; Cholangiocarcinoma - therapy ; Contrast Media - pharmacokinetics ; Embolization, Therapeutic ; Female ; Gadolinium DTPA - pharmacokinetics ; Hepatectomy ; Humans ; Liver Neoplasms - diagnosis ; Liver Neoplasms - therapy ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Portal Vein ; Prospective Studies ; Sensitivity and Specificity</subject><ispartof>Acta radiologica (1987), 2014-03, Vol.55 (2), p.149-154</ispartof><rights>The Foundation Acta Radiologica 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-b75d41c9a36159312aec0df472579a6a65389e0b4efe8a75d530447468def1ed3</citedby><cites>FETCH-LOGICAL-c403t-b75d41c9a36159312aec0df472579a6a65389e0b4efe8a75d530447468def1ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0284185113495833$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0284185113495833$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23908244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Geisel, Dominik</creatorcontrib><creatorcontrib>Lüdemann, Lutz</creatorcontrib><creatorcontrib>Wagner, Clemens</creatorcontrib><creatorcontrib>Stelter, Lars</creatorcontrib><creatorcontrib>Grieser, Christian</creatorcontrib><creatorcontrib>Malinowski, Maciej</creatorcontrib><creatorcontrib>Stockmann, Martin</creatorcontrib><creatorcontrib>Seehofer, Daniel</creatorcontrib><creatorcontrib>Hamm, Bernd</creatorcontrib><creatorcontrib>Gebauer, Bernhard</creatorcontrib><creatorcontrib>Denecke, Timm</creatorcontrib><title>Evaluation of gadolinium-EOB-DTPA uptake after portal vein embolization: value of an increased flip angle</title><title>Acta radiologica (1987)</title><addtitle>Acta Radiol</addtitle><description>Background
The optimal sequence for Gd-EOB-DTPA uptake measurement in the liver with the purpose of liver function measurement is still not defined.
Purpose
To prospectively evaluate the effect of an increased flip angle (FA) of a T1-weighted fat-saturated 3D sequence for the measurement of hepatocyte uptake of Gd-EOB-DTPA magnetic resonance imaging (MRI) after right portal vein embolization (PVE).
Material and Methods
Ten patients who received a PVE prior to an extended hemihepatectomy were examined 14 days after PVE using Gd-EOB-DTPA enhanced MRI of the liver using the standard FA of 10° and the increased FA of 30°.
Results
Relative enhancement of the right liver lobe (RLL) was 0.52 ± 0.12 for 10° and 1.41 ± 0.39 for 30°. Relative enhancement of the left liver lobe (LLL) was 0.58 ± 0.11 for 10° and 2.05 ± 0.61 for 30°. Relative enhancement of the RLL was significantly higher for 30° than for 10° (P = 0.009) and significantly higher in the 30° than in the 10° sequences (P = 0.005) for the LLL.
Conclusion
A flip angle of 30° increases the contrast between liver partitions with and without portal venous embolization. Thereby, the sensitivity for differences in uptake intensity is increased. This could be of value for a more exact determination of differences in regional liver function and, consequently, the estimation of the future remnant liver function.</description><subject>Adult</subject><subject>Aged</subject><subject>Cholangiocarcinoma - diagnosis</subject><subject>Cholangiocarcinoma - therapy</subject><subject>Contrast Media - pharmacokinetics</subject><subject>Embolization, Therapeutic</subject><subject>Female</subject><subject>Gadolinium DTPA - pharmacokinetics</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - therapy</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Portal Vein</subject><subject>Prospective Studies</subject><subject>Sensitivity and Specificity</subject><issn>0284-1851</issn><issn>1600-0455</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EoqWwMyGPLAFfbOeDrZTyIVUqQ5mja3KpXPKFnVSCX09CgQGJ6aS7532kexk7B3EFEIbXwo8URBpAqlhHUh6wMQRCeEJpfcjGw9kb7iN24txWCPBDDcds5MtYRL5SY2bmOyw6bE1d8TrnG8zqwlSmK7358ta7Wz1Pede0-Eoc85Ysb2rbYsF3ZCpO5bqHP77CN3zw0ODAipsqtYSOMp4Xpuk3m4JO2VGOhaOz7zlhL_fz1ezRWywfnmbThZcqIVtvHepMQRqjDEDHEnykVGS5Cn0dxhhgoGUUk1gryinCHtZSKBWqIMooB8rkhF3uvY2t3zpybVIal1JRYEV15xJQcQwqAhH0qNijqa2ds5QnjTUl2vcERDIUnPwtuI9cfNu7dUnZb-Cn0R7w9oDDDSXburNV_-3_wk9xXII7</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Geisel, Dominik</creator><creator>Lüdemann, Lutz</creator><creator>Wagner, Clemens</creator><creator>Stelter, Lars</creator><creator>Grieser, Christian</creator><creator>Malinowski, Maciej</creator><creator>Stockmann, Martin</creator><creator>Seehofer, Daniel</creator><creator>Hamm, Bernd</creator><creator>Gebauer, Bernhard</creator><creator>Denecke, Timm</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201403</creationdate><title>Evaluation of gadolinium-EOB-DTPA uptake after portal vein embolization: value of an increased flip angle</title><author>Geisel, Dominik ; Lüdemann, Lutz ; Wagner, Clemens ; Stelter, Lars ; Grieser, Christian ; Malinowski, Maciej ; Stockmann, Martin ; Seehofer, Daniel ; Hamm, Bernd ; Gebauer, Bernhard ; Denecke, Timm</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-b75d41c9a36159312aec0df472579a6a65389e0b4efe8a75d530447468def1ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cholangiocarcinoma - diagnosis</topic><topic>Cholangiocarcinoma - therapy</topic><topic>Contrast Media - pharmacokinetics</topic><topic>Embolization, Therapeutic</topic><topic>Female</topic><topic>Gadolinium DTPA - pharmacokinetics</topic><topic>Hepatectomy</topic><topic>Humans</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - therapy</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Portal Vein</topic><topic>Prospective Studies</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geisel, Dominik</creatorcontrib><creatorcontrib>Lüdemann, Lutz</creatorcontrib><creatorcontrib>Wagner, Clemens</creatorcontrib><creatorcontrib>Stelter, Lars</creatorcontrib><creatorcontrib>Grieser, Christian</creatorcontrib><creatorcontrib>Malinowski, Maciej</creatorcontrib><creatorcontrib>Stockmann, Martin</creatorcontrib><creatorcontrib>Seehofer, Daniel</creatorcontrib><creatorcontrib>Hamm, Bernd</creatorcontrib><creatorcontrib>Gebauer, Bernhard</creatorcontrib><creatorcontrib>Denecke, Timm</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta radiologica (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geisel, Dominik</au><au>Lüdemann, Lutz</au><au>Wagner, Clemens</au><au>Stelter, Lars</au><au>Grieser, Christian</au><au>Malinowski, Maciej</au><au>Stockmann, Martin</au><au>Seehofer, Daniel</au><au>Hamm, Bernd</au><au>Gebauer, Bernhard</au><au>Denecke, Timm</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of gadolinium-EOB-DTPA uptake after portal vein embolization: value of an increased flip angle</atitle><jtitle>Acta radiologica (1987)</jtitle><addtitle>Acta Radiol</addtitle><date>2014-03</date><risdate>2014</risdate><volume>55</volume><issue>2</issue><spage>149</spage><epage>154</epage><pages>149-154</pages><issn>0284-1851</issn><eissn>1600-0455</eissn><abstract>Background
The optimal sequence for Gd-EOB-DTPA uptake measurement in the liver with the purpose of liver function measurement is still not defined.
Purpose
To prospectively evaluate the effect of an increased flip angle (FA) of a T1-weighted fat-saturated 3D sequence for the measurement of hepatocyte uptake of Gd-EOB-DTPA magnetic resonance imaging (MRI) after right portal vein embolization (PVE).
Material and Methods
Ten patients who received a PVE prior to an extended hemihepatectomy were examined 14 days after PVE using Gd-EOB-DTPA enhanced MRI of the liver using the standard FA of 10° and the increased FA of 30°.
Results
Relative enhancement of the right liver lobe (RLL) was 0.52 ± 0.12 for 10° and 1.41 ± 0.39 for 30°. Relative enhancement of the left liver lobe (LLL) was 0.58 ± 0.11 for 10° and 2.05 ± 0.61 for 30°. Relative enhancement of the RLL was significantly higher for 30° than for 10° (P = 0.009) and significantly higher in the 30° than in the 10° sequences (P = 0.005) for the LLL.
Conclusion
A flip angle of 30° increases the contrast between liver partitions with and without portal venous embolization. Thereby, the sensitivity for differences in uptake intensity is increased. This could be of value for a more exact determination of differences in regional liver function and, consequently, the estimation of the future remnant liver function.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>23908244</pmid><doi>10.1177/0284185113495833</doi><tpages>6</tpages></addata></record> |
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| ispartof | Acta radiologica (1987), 2014-03, Vol.55 (2), p.149-154 |
| issn | 0284-1851 1600-0455 |
| language | eng |
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| source | MEDLINE; SAGE Complete |
| subjects | Adult Aged Cholangiocarcinoma - diagnosis Cholangiocarcinoma - therapy Contrast Media - pharmacokinetics Embolization, Therapeutic Female Gadolinium DTPA - pharmacokinetics Hepatectomy Humans Liver Neoplasms - diagnosis Liver Neoplasms - therapy Magnetic Resonance Imaging Male Middle Aged Portal Vein Prospective Studies Sensitivity and Specificity |
| title | Evaluation of gadolinium-EOB-DTPA uptake after portal vein embolization: value of an increased flip angle |
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