Efficiency and prognosis of whole brain irradiation combined with precise radiotherapy on triple-negative breast cancer
Aim: To investigate the treatment efficiency of whole brain irradiation combined with precise radiotherapy on triple-negative (TN) phenotype breast cancer patients with brain metastases and their survival times. Materials and Methods : A total of 112 metastatic breast cancer patients treated with wh...
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| Veröffentlicht in: | Journal of cancer research and therapeutics 2013-11, Vol.9 (7), p.169-172 |
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| creator | Wu, Xinhong Luo, Bo Wei, Shaozhong Luo, Yan Feng, Yaojun Xu, Juan Wei, Wei |
| description | Aim: To investigate the treatment efficiency of whole brain irradiation combined with precise radiotherapy on triple-negative (TN) phenotype breast cancer patients with brain metastases and their survival times.
Materials and Methods : A total of 112 metastatic breast cancer patients treated with whole brain irradiation and intensity modulated radiotherapy (IMRT) or 3D conformal radiotherapy (3DCRT) were analyzed. Thirty-seven patients were of TN phenotype. Objective response rates were compared. Survival times were estimated by using the Kaplan-Meier method. Log-rank test was used to compare the survival time difference between the TN and non-TN groups. Potential prognostic factors were determined by using a Cox proportional hazard regression model.
Results : The efficiency of radiotherapy treatment on TN and non-TN phenotypes was 96.2% and 97%, respectively. TN phenotype was associated with worse survival times than non-TN phenotype after radiotherapy (6.9 months vs. 17 months) (P < 0.01). On multivariate analysis, good prognosis was associated with non-TN status, lower graded prognosis assessment class, and nonexistence of active extracranial metastases.
Conclusion: After whole brain irradiation followed by IMRT or 3DCRT treatment, TN phenotype breast cancer patients with intracranial metastasis had high objective response rates but shorter survival time. With respect to survival in breast cancer patients with intracranial metastasis, the TN phenotype represents a significant adverse prognostic factor. |
| doi_str_mv | 10.4103/0973-1482.122518 |
| format | Article |
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Materials and Methods : A total of 112 metastatic breast cancer patients treated with whole brain irradiation and intensity modulated radiotherapy (IMRT) or 3D conformal radiotherapy (3DCRT) were analyzed. Thirty-seven patients were of TN phenotype. Objective response rates were compared. Survival times were estimated by using the Kaplan-Meier method. Log-rank test was used to compare the survival time difference between the TN and non-TN groups. Potential prognostic factors were determined by using a Cox proportional hazard regression model.
Results : The efficiency of radiotherapy treatment on TN and non-TN phenotypes was 96.2% and 97%, respectively. TN phenotype was associated with worse survival times than non-TN phenotype after radiotherapy (6.9 months vs. 17 months) (P < 0.01). On multivariate analysis, good prognosis was associated with non-TN status, lower graded prognosis assessment class, and nonexistence of active extracranial metastases.
Conclusion: After whole brain irradiation followed by IMRT or 3DCRT treatment, TN phenotype breast cancer patients with intracranial metastasis had high objective response rates but shorter survival time. With respect to survival in breast cancer patients with intracranial metastasis, the TN phenotype represents a significant adverse prognostic factor.</description><identifier>ISSN: 0973-1482</identifier><identifier>EISSN: 1998-4138</identifier><identifier>DOI: 10.4103/0973-1482.122518</identifier><identifier>PMID: 24516055</identifier><language>eng</language><publisher>India: Medknow Publications</publisher><subject>Adult ; Aged ; Brain - pathology ; Brain Neoplasms - drug therapy ; Brain Neoplasms - mortality ; Brain Neoplasms - radiotherapy ; Brain Neoplasms - secondary ; Breast cancer ; Cancer therapies ; Chemotherapy ; Cranial Irradiation ; Efficiency ; Female ; Gene amplification ; Genotype & phenotype ; Humans ; Medical prognosis ; Middle Aged ; Multivariate analysis ; NMR ; Nuclear magnetic resonance ; Prognosis ; Radiation therapy ; Radiotherapy, Conformal ; Receptor, ErbB-2 - metabolism ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; Response rates ; Retrospective Studies ; Survival analysis ; Survival Rate ; Triple Negative Breast Neoplasms - mortality ; Triple Negative Breast Neoplasms - pathology</subject><ispartof>Journal of cancer research and therapeutics, 2013-11, Vol.9 (7), p.169-172</ispartof><rights>Copyright Medknow Publications & Media Pvt Ltd Nov 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498n-147ba9ca8bb376bb613258c398fda40c7d3400445eaef5c1f01124cbb8c014d63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27435,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24516055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Xinhong</creatorcontrib><creatorcontrib>Luo, Bo</creatorcontrib><creatorcontrib>Wei, Shaozhong</creatorcontrib><creatorcontrib>Luo, Yan</creatorcontrib><creatorcontrib>Feng, Yaojun</creatorcontrib><creatorcontrib>Xu, Juan</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><title>Efficiency and prognosis of whole brain irradiation combined with precise radiotherapy on triple-negative breast cancer</title><title>Journal of cancer research and therapeutics</title><addtitle>J Cancer Res Ther</addtitle><description>Aim: To investigate the treatment efficiency of whole brain irradiation combined with precise radiotherapy on triple-negative (TN) phenotype breast cancer patients with brain metastases and their survival times.
Materials and Methods : A total of 112 metastatic breast cancer patients treated with whole brain irradiation and intensity modulated radiotherapy (IMRT) or 3D conformal radiotherapy (3DCRT) were analyzed. Thirty-seven patients were of TN phenotype. Objective response rates were compared. Survival times were estimated by using the Kaplan-Meier method. Log-rank test was used to compare the survival time difference between the TN and non-TN groups. Potential prognostic factors were determined by using a Cox proportional hazard regression model.
Results : The efficiency of radiotherapy treatment on TN and non-TN phenotypes was 96.2% and 97%, respectively. TN phenotype was associated with worse survival times than non-TN phenotype after radiotherapy (6.9 months vs. 17 months) (P < 0.01). On multivariate analysis, good prognosis was associated with non-TN status, lower graded prognosis assessment class, and nonexistence of active extracranial metastases.
Conclusion: After whole brain irradiation followed by IMRT or 3DCRT treatment, TN phenotype breast cancer patients with intracranial metastasis had high objective response rates but shorter survival time. With respect to survival in breast cancer patients with intracranial metastasis, the TN phenotype represents a significant adverse prognostic factor.</description><subject>Adult</subject><subject>Aged</subject><subject>Brain - pathology</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Brain Neoplasms - mortality</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Brain Neoplasms - secondary</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Cranial Irradiation</subject><subject>Efficiency</subject><subject>Female</subject><subject>Gene amplification</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Radiotherapy, Conformal</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Response rates</subject><subject>Retrospective Studies</subject><subject>Survival analysis</subject><subject>Survival Rate</subject><subject>Triple Negative Breast Neoplasms - mortality</subject><subject>Triple Negative Breast Neoplasms - pathology</subject><issn>0973-1482</issn><issn>1998-4138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUtv1DAURi0EokNhzwpZYsMmxc_EXkJVHlKlbtq1ZTs3HbcZe7CTRvPvcTRtBV15cc93dH0_hD5SciYo4V-J7nhDhWJnlDFJ1Su0oVqrRlCuXqPN8_gEvSvljhDZMabeohMmJG2JlBu0XAxD8AGiP2Abe7zP6TamEgpOA162aQTssg0Rh5xtH-wUUsQ-7VyI0OMlTNsaAR8K4HWepi1kuz_gSk057EdoItzW1MPqAVsm7G30kN-jN4MdC3x4fE_RzY-L6_NfzeXVz9_n3y4bL7SKdfnOWe2tco53rXMt5Uwqz7UaeiuI73ouCBFCgoVBejoQSpnwzilPqOhbfoq-HL31Y39mKJPZheJhHG2ENBdDhdZUCCVFRT-_QO_SnGPdrlIdI5RptlLkSPmcSskwmH0OO5sPhhKzlmLWq5v16uZYSo18ehTPbgf9c-CphQp8PwJLGifI5X6cF8imsvcxLf-Jm3_EhrbaPPXH_wJdMp2K</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Wu, Xinhong</creator><creator>Luo, Bo</creator><creator>Wei, Shaozhong</creator><creator>Luo, Yan</creator><creator>Feng, Yaojun</creator><creator>Xu, Juan</creator><creator>Wei, Wei</creator><general>Medknow Publications</general><general>Medknow Publications & Media Pvt. Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20131101</creationdate><title>Efficiency and prognosis of whole brain irradiation combined with precise radiotherapy on triple-negative breast cancer</title><author>Wu, Xinhong ; Luo, Bo ; Wei, Shaozhong ; Luo, Yan ; Feng, Yaojun ; Xu, Juan ; Wei, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498n-147ba9ca8bb376bb613258c398fda40c7d3400445eaef5c1f01124cbb8c014d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Brain - pathology</topic><topic>Brain Neoplasms - drug therapy</topic><topic>Brain Neoplasms - mortality</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Brain Neoplasms - secondary</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Cranial Irradiation</topic><topic>Efficiency</topic><topic>Female</topic><topic>Gene amplification</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Prognosis</topic><topic>Radiation therapy</topic><topic>Radiotherapy, Conformal</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Response rates</topic><topic>Retrospective Studies</topic><topic>Survival analysis</topic><topic>Survival Rate</topic><topic>Triple Negative Breast Neoplasms - mortality</topic><topic>Triple Negative Breast Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Xinhong</creatorcontrib><creatorcontrib>Luo, Bo</creatorcontrib><creatorcontrib>Wei, Shaozhong</creatorcontrib><creatorcontrib>Luo, Yan</creatorcontrib><creatorcontrib>Feng, Yaojun</creatorcontrib><creatorcontrib>Xu, Juan</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Xinhong</au><au>Luo, Bo</au><au>Wei, Shaozhong</au><au>Luo, Yan</au><au>Feng, Yaojun</au><au>Xu, Juan</au><au>Wei, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficiency and prognosis of whole brain irradiation combined with precise radiotherapy on triple-negative breast cancer</atitle><jtitle>Journal of cancer research and therapeutics</jtitle><addtitle>J Cancer Res Ther</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>9</volume><issue>7</issue><spage>169</spage><epage>172</epage><pages>169-172</pages><issn>0973-1482</issn><eissn>1998-4138</eissn><abstract>Aim: To investigate the treatment efficiency of whole brain irradiation combined with precise radiotherapy on triple-negative (TN) phenotype breast cancer patients with brain metastases and their survival times.
Materials and Methods : A total of 112 metastatic breast cancer patients treated with whole brain irradiation and intensity modulated radiotherapy (IMRT) or 3D conformal radiotherapy (3DCRT) were analyzed. Thirty-seven patients were of TN phenotype. Objective response rates were compared. Survival times were estimated by using the Kaplan-Meier method. Log-rank test was used to compare the survival time difference between the TN and non-TN groups. Potential prognostic factors were determined by using a Cox proportional hazard regression model.
Results : The efficiency of radiotherapy treatment on TN and non-TN phenotypes was 96.2% and 97%, respectively. TN phenotype was associated with worse survival times than non-TN phenotype after radiotherapy (6.9 months vs. 17 months) (P < 0.01). On multivariate analysis, good prognosis was associated with non-TN status, lower graded prognosis assessment class, and nonexistence of active extracranial metastases.
Conclusion: After whole brain irradiation followed by IMRT or 3DCRT treatment, TN phenotype breast cancer patients with intracranial metastasis had high objective response rates but shorter survival time. With respect to survival in breast cancer patients with intracranial metastasis, the TN phenotype represents a significant adverse prognostic factor.</abstract><cop>India</cop><pub>Medknow Publications</pub><pmid>24516055</pmid><doi>10.4103/0973-1482.122518</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Brain - pathology Brain Neoplasms - drug therapy Brain Neoplasms - mortality Brain Neoplasms - radiotherapy Brain Neoplasms - secondary Breast cancer Cancer therapies Chemotherapy Cranial Irradiation Efficiency Female Gene amplification Genotype & phenotype Humans Medical prognosis Middle Aged Multivariate analysis NMR Nuclear magnetic resonance Prognosis Radiation therapy Radiotherapy, Conformal Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Response rates Retrospective Studies Survival analysis Survival Rate Triple Negative Breast Neoplasms - mortality Triple Negative Breast Neoplasms - pathology |
| title | Efficiency and prognosis of whole brain irradiation combined with precise radiotherapy on triple-negative breast cancer |
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