EMILIN2 down-modulates the Wnt signalling pathway and suppresses breast cancer cell growth and migration

EMILIN2 is an extracellular matrix (ECM) protein that exerts contradictory effects within the tumour microenvironment: it induces apoptosis in a number of tumour cells, but it also enhances tumour neo‐angiogenesis. In this study, we describe a new mechanism by which EMILIN2 attenuates tumour cell vi...

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Veröffentlicht in:	The Journal of pathology 2014-03, Vol.232 (4), p.391-404
Hauptverfasser:	Marastoni, Stefano, Andreuzzi, Eva, Paulitti, Alice, Colladel, Roberta, Pellicani, Rosanna, Todaro, Federico, Schiavinato, Alvise, Bonaldo, Paolo, Colombatti, Alfonso, Mongiat, Maurizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - metabolism breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Movement Cell Proliferation Cell Survival Down-Regulation EMILIN2 extracellular matrix Female Gene Expression Regulation, Neoplastic Glycoproteins - genetics Glycoproteins - metabolism HEK293 Cells Humans Low Density Lipoprotein Receptor-Related Protein-6 - metabolism Mice Mice, Nude Mutation Neoplasm Invasiveness Phosphorylation Protein Binding Protein Interaction Domains and Motifs Time Factors Transcription Factors - metabolism Transfection Tumor Burden Tumor Microenvironment tumour microenvironment Wnt Signaling Pathway Wnt signalling Wnt1 Protein - genetics Wnt1 Protein - metabolism
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