Suppression of MAL gene expression in gastric cancer correlates with metastasis and mortality
The Myelin and lymphocyte-associated protein gene (MAL), which is located on the long arm of chromosome 2, assigned to the region cen-q13 in humans, has been reported as tumor suppressor in several cancers. The aim of this study was to clarify the clinical significance of MAL gene in gastric cancer....
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| Veröffentlicht in: | Fukuoka igaku zasshi = Hukuoka acta medica 2013-10, Vol.104 (10), p.344-349 |
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| creator | Kurashige, Junji Sawada, Genta Takahashi, Yusuke Eguchi, Hidetoshi Sudo, Tomoya Ikegami, Toru Yoshizumi, Tomoharu Soejima, Yuji Ikeda, Tetsuo Kawanaka, Hirofumi Uchiyama, Hideaki Yamashita, Yo-Ichi Morita, Masaru Oki, Eiji Saeki, Hiroshi Sugimachi, Keishi Watanabe, Masayuki Mori, Masaki Baba, Hideo Mimori, Koshi |
| description | The Myelin and lymphocyte-associated protein gene (MAL), which is located on the long arm of chromosome 2, assigned to the region cen-q13 in humans, has been reported as tumor suppressor in several cancers. The aim of this study was to clarify the clinical significance of MAL gene in gastric cancer.
The expression levels of MAL mRNA was examined using 50 resected gastric cancer specimens used by laser microdissected to determine the clinicopathological significance. MAL expression was then examined by real-time quantitative PCR assay, and we analyzed the correlation between MAL expression and clinicopathological factors.
In clinicopathologic analysis, the low MAL expression group showed significantly higher incidence of lymph node metastasis than the high expression group (79% and 46%, respectively, p < 0.05). Furthermore, the low MAL expression group had a significantly poorer prognosis than the high expression group (p < 0.05).
The MAL gene repression related with lymph node metastasis and poor prognosis in gastric cancer, suggesting that the MAL may be a new candidate node metastasis-suppressor gene for gastric cancer. |
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The expression levels of MAL mRNA was examined using 50 resected gastric cancer specimens used by laser microdissected to determine the clinicopathological significance. MAL expression was then examined by real-time quantitative PCR assay, and we analyzed the correlation between MAL expression and clinicopathological factors.
In clinicopathologic analysis, the low MAL expression group showed significantly higher incidence of lymph node metastasis than the high expression group (79% and 46%, respectively, p < 0.05). Furthermore, the low MAL expression group had a significantly poorer prognosis than the high expression group (p < 0.05).
The MAL gene repression related with lymph node metastasis and poor prognosis in gastric cancer, suggesting that the MAL may be a new candidate node metastasis-suppressor gene for gastric cancer.</description><identifier>ISSN: 0016-254X</identifier><identifier>PMID: 24511665</identifier><language>eng</language><publisher>Japan</publisher><subject>Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - pathology ; Chromosomes, Human, Pair 2 - genetics ; Down-Regulation - genetics ; Down-Regulation - physiology ; Female ; Gene Expression Regulation, Neoplastic - genetics ; Gene Expression Regulation, Neoplastic - physiology ; Genes, Tumor Suppressor ; Humans ; Lymphatic Metastasis - genetics ; Male ; Myelin and Lymphocyte-Associated Proteolipid Proteins - genetics ; Myelin and Lymphocyte-Associated Proteolipid Proteins - physiology ; Neoplasm Invasiveness - genetics ; Prognosis ; Real-Time Polymerase Chain Reaction ; RNA, Messenger - metabolism ; Stomach Neoplasms - genetics ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Tumor Cells, Cultured</subject><ispartof>Fukuoka igaku zasshi = Hukuoka acta medica, 2013-10, Vol.104 (10), p.344-349</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24511665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurashige, Junji</creatorcontrib><creatorcontrib>Sawada, Genta</creatorcontrib><creatorcontrib>Takahashi, Yusuke</creatorcontrib><creatorcontrib>Eguchi, Hidetoshi</creatorcontrib><creatorcontrib>Sudo, Tomoya</creatorcontrib><creatorcontrib>Ikegami, Toru</creatorcontrib><creatorcontrib>Yoshizumi, Tomoharu</creatorcontrib><creatorcontrib>Soejima, Yuji</creatorcontrib><creatorcontrib>Ikeda, Tetsuo</creatorcontrib><creatorcontrib>Kawanaka, Hirofumi</creatorcontrib><creatorcontrib>Uchiyama, Hideaki</creatorcontrib><creatorcontrib>Yamashita, Yo-Ichi</creatorcontrib><creatorcontrib>Morita, Masaru</creatorcontrib><creatorcontrib>Oki, Eiji</creatorcontrib><creatorcontrib>Saeki, Hiroshi</creatorcontrib><creatorcontrib>Sugimachi, Keishi</creatorcontrib><creatorcontrib>Watanabe, Masayuki</creatorcontrib><creatorcontrib>Mori, Masaki</creatorcontrib><creatorcontrib>Baba, Hideo</creatorcontrib><creatorcontrib>Mimori, Koshi</creatorcontrib><title>Suppression of MAL gene expression in gastric cancer correlates with metastasis and mortality</title><title>Fukuoka igaku zasshi = Hukuoka acta medica</title><addtitle>Fukuoka Igaku Zasshi</addtitle><description>The Myelin and lymphocyte-associated protein gene (MAL), which is located on the long arm of chromosome 2, assigned to the region cen-q13 in humans, has been reported as tumor suppressor in several cancers. The aim of this study was to clarify the clinical significance of MAL gene in gastric cancer.
The expression levels of MAL mRNA was examined using 50 resected gastric cancer specimens used by laser microdissected to determine the clinicopathological significance. MAL expression was then examined by real-time quantitative PCR assay, and we analyzed the correlation between MAL expression and clinicopathological factors.
In clinicopathologic analysis, the low MAL expression group showed significantly higher incidence of lymph node metastasis than the high expression group (79% and 46%, respectively, p < 0.05). Furthermore, the low MAL expression group had a significantly poorer prognosis than the high expression group (p < 0.05).
The MAL gene repression related with lymph node metastasis and poor prognosis in gastric cancer, suggesting that the MAL may be a new candidate node metastasis-suppressor gene for gastric cancer.</description><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Chromosomes, Human, Pair 2 - genetics</subject><subject>Down-Regulation - genetics</subject><subject>Down-Regulation - physiology</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Gene Expression Regulation, Neoplastic - physiology</subject><subject>Genes, Tumor Suppressor</subject><subject>Humans</subject><subject>Lymphatic Metastasis - genetics</subject><subject>Male</subject><subject>Myelin and Lymphocyte-Associated Proteolipid Proteins - genetics</subject><subject>Myelin and Lymphocyte-Associated Proteolipid Proteins - physiology</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Prognosis</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>RNA, Messenger - metabolism</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Tumor Cells, Cultured</subject><issn>0016-254X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90EtLxDAUBeAsFGcY5y9Ilm4KvUmTNsth8AUzuFDBjZTb9HaM9GWSovPvLTi6unDOx1ncM7ZMU9CJUNnrgq1DcFWaCgFGQHHBFiJTAFqrJXt7msbR0wyGng8N3292_EA9cfr-j13PDxiid5Zb7C15bgfvqcVIgX-5-M47ijPA4ALHvubd4CO2Lh4v2XmDbaD16a7Yy-3N8_Y-2T3ePWw3u-QDTBYTZZrcWGGtkDbNERpdgNI6l5BmApSFnOZWSayohqrQpNFogYUoGtRFJeWKXf_ujn74nCjEsnPBUttiT8MUSsiMgUwImc_06kSnqqO6HL3r0B_Lv5fIHx-BXbo</recordid><startdate>20131025</startdate><enddate>20131025</enddate><creator>Kurashige, Junji</creator><creator>Sawada, Genta</creator><creator>Takahashi, Yusuke</creator><creator>Eguchi, Hidetoshi</creator><creator>Sudo, Tomoya</creator><creator>Ikegami, Toru</creator><creator>Yoshizumi, Tomoharu</creator><creator>Soejima, Yuji</creator><creator>Ikeda, Tetsuo</creator><creator>Kawanaka, Hirofumi</creator><creator>Uchiyama, Hideaki</creator><creator>Yamashita, Yo-Ichi</creator><creator>Morita, Masaru</creator><creator>Oki, Eiji</creator><creator>Saeki, Hiroshi</creator><creator>Sugimachi, Keishi</creator><creator>Watanabe, Masayuki</creator><creator>Mori, Masaki</creator><creator>Baba, Hideo</creator><creator>Mimori, Koshi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20131025</creationdate><title>Suppression of MAL gene expression in gastric cancer correlates with metastasis and mortality</title><author>Kurashige, Junji ; 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The aim of this study was to clarify the clinical significance of MAL gene in gastric cancer.
The expression levels of MAL mRNA was examined using 50 resected gastric cancer specimens used by laser microdissected to determine the clinicopathological significance. MAL expression was then examined by real-time quantitative PCR assay, and we analyzed the correlation between MAL expression and clinicopathological factors.
In clinicopathologic analysis, the low MAL expression group showed significantly higher incidence of lymph node metastasis than the high expression group (79% and 46%, respectively, p < 0.05). Furthermore, the low MAL expression group had a significantly poorer prognosis than the high expression group (p < 0.05).
The MAL gene repression related with lymph node metastasis and poor prognosis in gastric cancer, suggesting that the MAL may be a new candidate node metastasis-suppressor gene for gastric cancer.</abstract><cop>Japan</cop><pmid>24511665</pmid><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Chromosomes, Human, Pair 2 - genetics Down-Regulation - genetics Down-Regulation - physiology Female Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology Genes, Tumor Suppressor Humans Lymphatic Metastasis - genetics Male Myelin and Lymphocyte-Associated Proteolipid Proteins - genetics Myelin and Lymphocyte-Associated Proteolipid Proteins - physiology Neoplasm Invasiveness - genetics Prognosis Real-Time Polymerase Chain Reaction RNA, Messenger - metabolism Stomach Neoplasms - genetics Stomach Neoplasms - mortality Stomach Neoplasms - pathology Tumor Cells, Cultured |
| title | Suppression of MAL gene expression in gastric cancer correlates with metastasis and mortality |
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