RIG-I Modulates Src-Mediated AKT Activation to Restrain Leukemic Stemness

Retinoic acid (RA)-inducible gene I (RIG-I) is highly upregulated and functionally implicated in the RA-induced maturation of acute myeloid leukemia (AML) blasts. However, the underlying mechanism and the biological relevance of RIG-I expression to the maintenance of leukemogenic potential are poorl...

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Veröffentlicht in:	Molecular cell 2014-02, Vol.53 (3), p.407-419
Hauptverfasser:	Li, Xian-Yang, Jiang, Lin-Jia, Chen, Lei, Ding, Meng-Lei, Guo, He-Zhou, Zhang, Wu, Zhang, Hong-Xin, Ma, Xiao-Dan, Liu, Xiang-Zhen, Xi, Xiao-Dong, Chen, Sai-Juan, Chen, Zhu, Zhu, Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Adaptor Proteins, Signal Transducing - physiology Amino Acid Sequence Cell Line, Tumor DEAD Box Protein 58 DEAD-box RNA Helicases - chemistry DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - physiology Enzyme Activation Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Models, Genetic Molecular Sequence Data Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-akt - physiology Proto-Oncogene Proteins pp60(c-src) - metabolism Proto-Oncogene Proteins pp60(c-src) - physiology Receptors, Immunologic Sequence Alignment Sequence Analysis, Protein TOR Serine-Threonine Kinases - metabolism TOR Serine-Threonine Kinases - physiology Up-Regulation
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