KLRG1+ NK cells protect T-bet-deficient mice from pulmonary metastatic colorectal carcinoma

We studied the developmental and functional mechanisms behind NK cell-mediated antitumor responses against metastatic colorectal carcinoma (CRC) in mice. In particular, we focused on investigating the significance of T-box transcription factors and the immunotherapeutic relevance of IL-15 in the dev...

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Veröffentlicht in:	The Journal of immunology (1950) 2014-02, Vol.192 (4), p.1954-1961
Hauptverfasser:	Malaisé, Muriel, Rovira, Jordi, Renner, Philipp, Eggenhofer, Elke, Sabet-Baktach, Manije, Lantow, Margareta, Lang, Sven A, Koehl, Gudrun E, Farkas, Stefan A, Loss, Martin, Agha, Ayman, Campistol, Josep M, Schlitt, Hans J, Geissler, Edward K, Kroemer, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Cell Differentiation - immunology Cells, Cultured Colorectal Neoplasms - immunology Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Homeodomain Proteins - genetics Immunotherapy Interferon-gamma - genetics Interleukin-15 - metabolism Killer Cells, Natural - cytology Killer Cells, Natural - immunology Lung Neoplasms - prevention & control Lung Neoplasms - secondary Lung Neoplasms - therapy Mice Mice, Inbred BALB C Mice, Knockout Perforin Pore Forming Cytotoxic Proteins - genetics Receptors, Immunologic - metabolism Receptors, Interleukin-15 - metabolism Recombinant Fusion Proteins - therapeutic use T-Box Domain Proteins - deficiency T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism
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