Diffuse osteosclerosis in a patient with prostate cancer
A 61-year-old man was referred to our outpatient clinic because of severe bilateral upper leg pain for 1 year. On admission, the patient had anemia and a high serum alkaline phosphatase level. Lumbar and femoral neck T-scores were +10.5 and +9.6, respectively. His radius 33 % T-score was −2.8. Plain...
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| Veröffentlicht in: | Osteoporosis international 2014-03, Vol.25 (3), p.1181-1185 |
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| creator | Üstün, N. Üstün, I. Özgür, T. Atci, N. Aydoğan, F. Sümbül, A. T. Turhanoğlu, A. D. |
| description | A 61-year-old man was referred to our outpatient clinic because of severe bilateral upper leg pain for 1 year. On admission, the patient had anemia and a high serum alkaline phosphatase level. Lumbar and femoral neck T-scores were +10.5 and +9.6, respectively. His radius 33 % T-score was −2.8. Plain radiographs of the patient's pelvis, spine, and long bones revealed osteosclerosis. The patient had previously undergone a prostate biopsy, which showed prostate adenocarcinoma (Gleason score 3 + 4). The patient's total and free prostate-specific antigen were very high. According to previous records, the patient did not have anemia, and his serum alkaline phosphatase (ALP) level was normal. An abdominal radiograph taken 2 years earlier revealed a normal spine and pelvic bone. Bone scintigraphy yielded nontypical findings for prostate cancer metastasis. Computed tomography of the patient's thorax and abdomen showed heterogeneous sclerotic areas in all bones consistent with prostate cancer metastasis. A bone marrow biopsy disclosed disseminated carcinomatosis of bone marrow in association with prostate cancer. Clinicians should be aware of the possibility of prostate malignancy as a cause of high bone mineral density (BMD), even in the absence of typical localized findings on plain radiographs. |
| doi_str_mv | 10.1007/s00198-013-2545-9 |
| format | Article |
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T. ; Turhanoğlu, A. D.</creator><creatorcontrib>Üstün, N. ; Üstün, I. ; Özgür, T. ; Atci, N. ; Aydoğan, F. ; Sümbül, A. T. ; Turhanoğlu, A. D.</creatorcontrib><description>A 61-year-old man was referred to our outpatient clinic because of severe bilateral upper leg pain for 1 year. On admission, the patient had anemia and a high serum alkaline phosphatase level. Lumbar and femoral neck T-scores were +10.5 and +9.6, respectively. His radius 33 % T-score was −2.8. Plain radiographs of the patient's pelvis, spine, and long bones revealed osteosclerosis. The patient had previously undergone a prostate biopsy, which showed prostate adenocarcinoma (Gleason score 3 + 4). The patient's total and free prostate-specific antigen were very high. According to previous records, the patient did not have anemia, and his serum alkaline phosphatase (ALP) level was normal. An abdominal radiograph taken 2 years earlier revealed a normal spine and pelvic bone. Bone scintigraphy yielded nontypical findings for prostate cancer metastasis. Computed tomography of the patient's thorax and abdomen showed heterogeneous sclerotic areas in all bones consistent with prostate cancer metastasis. A bone marrow biopsy disclosed disseminated carcinomatosis of bone marrow in association with prostate cancer. Clinicians should be aware of the possibility of prostate malignancy as a cause of high bone mineral density (BMD), even in the absence of typical localized findings on plain radiographs.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-013-2545-9</identifier><identifier>PMID: 24136106</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Absorptiometry, Photon ; Adenocarcinoma - complications ; Adenocarcinoma - diagnosis ; Adenocarcinoma - secondary ; Bone density ; Bone Marrow Neoplasms - complications ; Bone Marrow Neoplasms - diagnostic imaging ; Bone Marrow Neoplasms - secondary ; Bones ; Case Report ; Endocrinology ; Femur Neck - physiopathology ; Humans ; Lumbar Vertebrae - physiopathology ; Male ; Medicine ; Medicine & Public Health ; Metastasis ; Middle Aged ; Orthopedics ; Osteosclerosis - diagnostic imaging ; Osteosclerosis - etiology ; Osteosclerosis - physiopathology ; Prostate cancer ; Prostatic Neoplasms - diagnosis ; Rheumatology</subject><ispartof>Osteoporosis international, 2014-03, Vol.25 (3), p.1181-1185</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2013</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-36c8f765189d54c54e22ecd8d68d907d21343b3821999f57927ad62122393bd53</citedby><cites>FETCH-LOGICAL-c372t-36c8f765189d54c54e22ecd8d68d907d21343b3821999f57927ad62122393bd53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-013-2545-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-013-2545-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24136106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Üstün, N.</creatorcontrib><creatorcontrib>Üstün, I.</creatorcontrib><creatorcontrib>Özgür, T.</creatorcontrib><creatorcontrib>Atci, N.</creatorcontrib><creatorcontrib>Aydoğan, F.</creatorcontrib><creatorcontrib>Sümbül, A. T.</creatorcontrib><creatorcontrib>Turhanoğlu, A. D.</creatorcontrib><title>Diffuse osteosclerosis in a patient with prostate cancer</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>A 61-year-old man was referred to our outpatient clinic because of severe bilateral upper leg pain for 1 year. On admission, the patient had anemia and a high serum alkaline phosphatase level. Lumbar and femoral neck T-scores were +10.5 and +9.6, respectively. His radius 33 % T-score was −2.8. Plain radiographs of the patient's pelvis, spine, and long bones revealed osteosclerosis. The patient had previously undergone a prostate biopsy, which showed prostate adenocarcinoma (Gleason score 3 + 4). The patient's total and free prostate-specific antigen were very high. According to previous records, the patient did not have anemia, and his serum alkaline phosphatase (ALP) level was normal. An abdominal radiograph taken 2 years earlier revealed a normal spine and pelvic bone. Bone scintigraphy yielded nontypical findings for prostate cancer metastasis. Computed tomography of the patient's thorax and abdomen showed heterogeneous sclerotic areas in all bones consistent with prostate cancer metastasis. A bone marrow biopsy disclosed disseminated carcinomatosis of bone marrow in association with prostate cancer. Clinicians should be aware of the possibility of prostate malignancy as a cause of high bone mineral density (BMD), even in the absence of typical localized findings on plain radiographs.</description><subject>Absorptiometry, Photon</subject><subject>Adenocarcinoma - complications</subject><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - secondary</subject><subject>Bone density</subject><subject>Bone Marrow Neoplasms - complications</subject><subject>Bone Marrow Neoplasms - diagnostic imaging</subject><subject>Bone Marrow Neoplasms - secondary</subject><subject>Bones</subject><subject>Case Report</subject><subject>Endocrinology</subject><subject>Femur Neck - physiopathology</subject><subject>Humans</subject><subject>Lumbar Vertebrae - physiopathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Orthopedics</subject><subject>Osteosclerosis - diagnostic imaging</subject><subject>Osteosclerosis - etiology</subject><subject>Osteosclerosis - physiopathology</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Rheumatology</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LxDAURYMozjj6A9xIwY2bal4-mryljJ8w4EbBXcikqXbotGOTIv57M1RFBFchvHPvSw4hx0DPgVJ1ESgF1DkFnjMpZI47ZAqCpxsWcpdMKXKVo4DnCTkIYUVTBlHtkwkTwAugxZToq7qqhuCzLkTfBdf4vgt1yOo2s9nGxtq3MXuv42u2SYNoo8-cbZ3vD8leZZvgj77OGXm6uX6c3-WLh9v7-eUid1yxmPPC6UoVEjSWUjgpPGPelbosdIlUlQy44EuuGSBiJRUyZcuCAWMc-bKUfEbOxt60_23wIZp1HZxvGtv6bggGBCJwhVwn9PQPuuqGvk2v21KKSwqCJgpGyqUPhd5XZtPXa9t_GKBmq9WMWk3SarZaDabMyVfzsFz78ifx7TEBbARCGrUvvv-1-t_WTzOkf-8</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Üstün, N.</creator><creator>Üstün, I.</creator><creator>Özgür, T.</creator><creator>Atci, N.</creator><creator>Aydoğan, F.</creator><creator>Sümbül, A. 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T. ; Turhanoğlu, A. 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T.</au><au>Turhanoğlu, A. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diffuse osteosclerosis in a patient with prostate cancer</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>25</volume><issue>3</issue><spage>1181</spage><epage>1185</epage><pages>1181-1185</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>A 61-year-old man was referred to our outpatient clinic because of severe bilateral upper leg pain for 1 year. On admission, the patient had anemia and a high serum alkaline phosphatase level. Lumbar and femoral neck T-scores were +10.5 and +9.6, respectively. His radius 33 % T-score was −2.8. Plain radiographs of the patient's pelvis, spine, and long bones revealed osteosclerosis. The patient had previously undergone a prostate biopsy, which showed prostate adenocarcinoma (Gleason score 3 + 4). The patient's total and free prostate-specific antigen were very high. According to previous records, the patient did not have anemia, and his serum alkaline phosphatase (ALP) level was normal. An abdominal radiograph taken 2 years earlier revealed a normal spine and pelvic bone. Bone scintigraphy yielded nontypical findings for prostate cancer metastasis. Computed tomography of the patient's thorax and abdomen showed heterogeneous sclerotic areas in all bones consistent with prostate cancer metastasis. A bone marrow biopsy disclosed disseminated carcinomatosis of bone marrow in association with prostate cancer. Clinicians should be aware of the possibility of prostate malignancy as a cause of high bone mineral density (BMD), even in the absence of typical localized findings on plain radiographs.</abstract><cop>London</cop><pub>Springer London</pub><pmid>24136106</pmid><doi>10.1007/s00198-013-2545-9</doi><tpages>5</tpages></addata></record> |
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| ispartof | Osteoporosis international, 2014-03, Vol.25 (3), p.1181-1185 |
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| subjects | Absorptiometry, Photon Adenocarcinoma - complications Adenocarcinoma - diagnosis Adenocarcinoma - secondary Bone density Bone Marrow Neoplasms - complications Bone Marrow Neoplasms - diagnostic imaging Bone Marrow Neoplasms - secondary Bones Case Report Endocrinology Femur Neck - physiopathology Humans Lumbar Vertebrae - physiopathology Male Medicine Medicine & Public Health Metastasis Middle Aged Orthopedics Osteosclerosis - diagnostic imaging Osteosclerosis - etiology Osteosclerosis - physiopathology Prostate cancer Prostatic Neoplasms - diagnosis Rheumatology |
| title | Diffuse osteosclerosis in a patient with prostate cancer |
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