Huaier polysaccharides suppresses hepatocarcinoma MHCC97-H cell metastasis via inactivation of EMT and AEG-1 pathway
We have recently reported that astrocyte elevated gene-1 (AEG-1) might be an epithelial–mesenchymal transition (EMT) associated biomarker in human hepatocellular carcinoma (HCC), and play an important role in the progression of hepatocellular carcinoma. To extend our study, we examined here the anti...
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| Veröffentlicht in: | International journal of biological macromolecules 2014-03, Vol.64, p.106-110 |
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| container_title | International journal of biological macromolecules |
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| creator | Zheng, Jiasheng Li, Cong Wu, Xia Liu, Mengmeng Sun, Xicai Yang, Yingzhuo Hao, Meijun Sheng, Shoupeng Sun, Yu Zhang, Honghai Long, Jiang Liang, Yi Hu, Caixia |
| description | We have recently reported that astrocyte elevated gene-1 (AEG-1) might be an epithelial–mesenchymal transition (EMT) associated biomarker in human hepatocellular carcinoma (HCC), and play an important role in the progression of hepatocellular carcinoma. To extend our study, we examined here the anti-invasive and metastatic effects of Huaier polysaccharide (HP) on human HCC cell line MHCC97-H and explored its possible mechanism of action. Treatment with HP dose-dependently inhibited the proliferation, adhesion, migration and invasion of MHCC97-H cells in vitro. This was achieved not only by reducing the expression of AEG-1 and N-cadherin, but also by enhancing E-cadherin expression. Therefore, these data suggested that HP can inhibit the growth and metastatic potential of MHCC97-H cells through modulation of the AEG-1/EMT pathway. |
| doi_str_mv | 10.1016/j.ijbiomac.2013.11.034 |
| format | Article |
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To extend our study, we examined here the anti-invasive and metastatic effects of Huaier polysaccharide (HP) on human HCC cell line MHCC97-H and explored its possible mechanism of action. Treatment with HP dose-dependently inhibited the proliferation, adhesion, migration and invasion of MHCC97-H cells in vitro. This was achieved not only by reducing the expression of AEG-1 and N-cadherin, but also by enhancing E-cadherin expression. Therefore, these data suggested that HP can inhibit the growth and metastatic potential of MHCC97-H cells through modulation of the AEG-1/EMT pathway.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2013.11.034</identifier><identifier>PMID: 24321491</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Anti-metastasis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - toxicity ; Astrocyte elevated gene-1 (AEG-1) ; Cadherins - metabolism ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Cell Adhesion - drug effects ; Cell Adhesion Molecules - metabolism ; Cell Line, Tumor ; Cell Movement - drug effects ; Epithelial-Mesenchymal Transition - drug effects ; Hepatocellular carcinoma ; Huaier polysaccharide ; Humans ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; MHCC97-H cells ; Neoplasm Metastasis ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Polysaccharides - chemistry ; Polysaccharides - pharmacology ; Polysaccharides - toxicity ; Signal Transduction - drug effects</subject><ispartof>International journal of biological macromolecules, 2014-03, Vol.64, p.106-110</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-3b0308fbe9e97e65e9e5eda1fb0c3f369dddacb0d044c3f22352c877b81c9c133</citedby><cites>FETCH-LOGICAL-c368t-3b0308fbe9e97e65e9e5eda1fb0c3f369dddacb0d044c3f22352c877b81c9c133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijbiomac.2013.11.034$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24321491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Jiasheng</creatorcontrib><creatorcontrib>Li, Cong</creatorcontrib><creatorcontrib>Wu, Xia</creatorcontrib><creatorcontrib>Liu, Mengmeng</creatorcontrib><creatorcontrib>Sun, Xicai</creatorcontrib><creatorcontrib>Yang, Yingzhuo</creatorcontrib><creatorcontrib>Hao, Meijun</creatorcontrib><creatorcontrib>Sheng, Shoupeng</creatorcontrib><creatorcontrib>Sun, Yu</creatorcontrib><creatorcontrib>Zhang, Honghai</creatorcontrib><creatorcontrib>Long, Jiang</creatorcontrib><creatorcontrib>Liang, Yi</creatorcontrib><creatorcontrib>Hu, Caixia</creatorcontrib><title>Huaier polysaccharides suppresses hepatocarcinoma MHCC97-H cell metastasis via inactivation of EMT and AEG-1 pathway</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>We have recently reported that astrocyte elevated gene-1 (AEG-1) might be an epithelial–mesenchymal transition (EMT) associated biomarker in human hepatocellular carcinoma (HCC), and play an important role in the progression of hepatocellular carcinoma. To extend our study, we examined here the anti-invasive and metastatic effects of Huaier polysaccharide (HP) on human HCC cell line MHCC97-H and explored its possible mechanism of action. Treatment with HP dose-dependently inhibited the proliferation, adhesion, migration and invasion of MHCC97-H cells in vitro. This was achieved not only by reducing the expression of AEG-1 and N-cadherin, but also by enhancing E-cadherin expression. Therefore, these data suggested that HP can inhibit the growth and metastatic potential of MHCC97-H cells through modulation of the AEG-1/EMT pathway.</description><subject>Anti-metastasis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Astrocyte elevated gene-1 (AEG-1)</subject><subject>Cadherins - metabolism</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - drug effects</subject><subject>Epithelial-Mesenchymal Transition - drug effects</subject><subject>Hepatocellular carcinoma</subject><subject>Huaier polysaccharide</subject><subject>Humans</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>MHCC97-H cells</subject><subject>Neoplasm Metastasis</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Polysaccharides - chemistry</subject><subject>Polysaccharides - pharmacology</subject><subject>Polysaccharides - toxicity</subject><subject>Signal Transduction - drug effects</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v2zAMhoVhw5p1-wuFjrvYEy3HH7cVQdYMaLFLdxZoikYUxJYn2Rny76sg7a4DCJAgXvIlHyHuQOWgoPp2yN2hc35AygsFOgfIlS7fiRU0dZsppfR7sVJQQtaAVjfiU4yH1K3W0HwUN0WpCyhbWIl5t6DjICd_PEck2mNwlqOMyzQFjjGVe55w9oSB3JgM5dNus2nrbCeJj0c58IwxhYvy5FC6EWl2J5ydH6Xv5fbpWeJo5f32IQOZFu3_4vmz-NDjMfKX13wrfv_YPm922eOvh5-b-8eMdNXMme6UVk3fccttzdU65TVbhL5TpHtdtdZapE5ZVZapURR6XVBT110D1BJofSu-XvdOwf9ZOM5mcPFyNY7sl2gSghZ0Xeg6SaurlIKPMXBvpuAGDGcDylyIm4N5I24uxA2AScTT4N2rx9INbP-NvSFOgu9XAadPT4m1ieR4JLYuMM3Gevc_jxdZvJY-</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Zheng, Jiasheng</creator><creator>Li, Cong</creator><creator>Wu, Xia</creator><creator>Liu, Mengmeng</creator><creator>Sun, Xicai</creator><creator>Yang, Yingzhuo</creator><creator>Hao, Meijun</creator><creator>Sheng, Shoupeng</creator><creator>Sun, Yu</creator><creator>Zhang, Honghai</creator><creator>Long, Jiang</creator><creator>Liang, Yi</creator><creator>Hu, Caixia</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140301</creationdate><title>Huaier polysaccharides suppresses hepatocarcinoma MHCC97-H cell metastasis via inactivation of EMT and AEG-1 pathway</title><author>Zheng, Jiasheng ; Li, Cong ; Wu, Xia ; Liu, Mengmeng ; Sun, Xicai ; Yang, Yingzhuo ; Hao, Meijun ; Sheng, Shoupeng ; Sun, Yu ; Zhang, Honghai ; Long, Jiang ; Liang, Yi ; Hu, Caixia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-3b0308fbe9e97e65e9e5eda1fb0c3f369dddacb0d044c3f22352c877b81c9c133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Anti-metastasis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - toxicity</topic><topic>Astrocyte elevated gene-1 (AEG-1)</topic><topic>Cadherins - metabolism</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - drug effects</topic><topic>Epithelial-Mesenchymal Transition - drug effects</topic><topic>Hepatocellular carcinoma</topic><topic>Huaier polysaccharide</topic><topic>Humans</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>MHCC97-H cells</topic><topic>Neoplasm Metastasis</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Polysaccharides - chemistry</topic><topic>Polysaccharides - pharmacology</topic><topic>Polysaccharides - toxicity</topic><topic>Signal Transduction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Jiasheng</creatorcontrib><creatorcontrib>Li, Cong</creatorcontrib><creatorcontrib>Wu, Xia</creatorcontrib><creatorcontrib>Liu, Mengmeng</creatorcontrib><creatorcontrib>Sun, Xicai</creatorcontrib><creatorcontrib>Yang, Yingzhuo</creatorcontrib><creatorcontrib>Hao, Meijun</creatorcontrib><creatorcontrib>Sheng, Shoupeng</creatorcontrib><creatorcontrib>Sun, Yu</creatorcontrib><creatorcontrib>Zhang, Honghai</creatorcontrib><creatorcontrib>Long, Jiang</creatorcontrib><creatorcontrib>Liang, Yi</creatorcontrib><creatorcontrib>Hu, Caixia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Jiasheng</au><au>Li, Cong</au><au>Wu, Xia</au><au>Liu, Mengmeng</au><au>Sun, Xicai</au><au>Yang, Yingzhuo</au><au>Hao, Meijun</au><au>Sheng, Shoupeng</au><au>Sun, Yu</au><au>Zhang, Honghai</au><au>Long, Jiang</au><au>Liang, Yi</au><au>Hu, Caixia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Huaier polysaccharides suppresses hepatocarcinoma MHCC97-H cell metastasis via inactivation of EMT and AEG-1 pathway</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>64</volume><spage>106</spage><epage>110</epage><pages>106-110</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>We have recently reported that astrocyte elevated gene-1 (AEG-1) might be an epithelial–mesenchymal transition (EMT) associated biomarker in human hepatocellular carcinoma (HCC), and play an important role in the progression of hepatocellular carcinoma. To extend our study, we examined here the anti-invasive and metastatic effects of Huaier polysaccharide (HP) on human HCC cell line MHCC97-H and explored its possible mechanism of action. Treatment with HP dose-dependently inhibited the proliferation, adhesion, migration and invasion of MHCC97-H cells in vitro. This was achieved not only by reducing the expression of AEG-1 and N-cadherin, but also by enhancing E-cadherin expression. Therefore, these data suggested that HP can inhibit the growth and metastatic potential of MHCC97-H cells through modulation of the AEG-1/EMT pathway.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24321491</pmid><doi>10.1016/j.ijbiomac.2013.11.034</doi><tpages>5</tpages></addata></record> |
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| subjects | Anti-metastasis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Astrocyte elevated gene-1 (AEG-1) Cadherins - metabolism Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Adhesion - drug effects Cell Adhesion Molecules - metabolism Cell Line, Tumor Cell Movement - drug effects Epithelial-Mesenchymal Transition - drug effects Hepatocellular carcinoma Huaier polysaccharide Humans Liver Neoplasms - metabolism Liver Neoplasms - pathology MHCC97-H cells Neoplasm Metastasis Plant Extracts - chemistry Plant Extracts - pharmacology Polysaccharides - chemistry Polysaccharides - pharmacology Polysaccharides - toxicity Signal Transduction - drug effects |
| title | Huaier polysaccharides suppresses hepatocarcinoma MHCC97-H cell metastasis via inactivation of EMT and AEG-1 pathway |
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