Development and validation of a rapid and high-sensitivity liquid chromatography-tandem mass spectrometry assay for the determination of neostigmine in small-volume beagle dog plasma and its application to a pharmacokinetic study

ABSTRACT A simple, rapid and high sensitive liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method for the determination of neostigmine in small‐volume beagle dog plasma was developed to assess the plasma pharmacokinetics of neostigmine. After protein precipitation in a Sirocco 96‐well fil...

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Veröffentlicht in:	Biomedical chromatography 2014-03, Vol.28 (3), p.354-361
Hauptverfasser:	Cao, Di, Li, Wenxue, Zhao, Xin, Ye, Xiaolan, Sun, Fanlu, Li, Jinying, Song, Fenyun, Fan, Guorong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beagle dogs Chromatography, High Pressure Liquid - methods Dogs Drug Stability LC-MS/MS Linear Models neostigmine Neostigmine - blood Neostigmine - chemistry Neostigmine - pharmacokinetics pharmacokinetic study Reproducibility of Results Sensitivity and Specificity Sirocco 96-well filtration plates Tandem Mass Spectrometry - methods
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