Angiopoietin-1 regulates microvascular reactivity and protects the microcirculation during acute endothelial dysfunction: Role of eNOS and VE-cadherin

The growth factor angiopoietin-1 (Ang-1) plays an essential role in angiogenesis and vascular homeostasis. Nevertheless, the role of Ang-1 in regulating vascular tone and blood flow is largely unexplored. Endothelial nitric oxide synthase (eNOS) and the junctional protein VE-cadherin are part of the...

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Veröffentlicht in:	Pharmacological research 2014-02, Vol.80, p.43-51
Hauptverfasser:	Alfieri, Alessio, Ong, Albert C.M., Kammerer, Richard A., Solanky, Tirupa, Bate, Simon, Tasab, Mohammed, Brown, Nicola J., Brookes, Zoe L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoetin-1 Angiopoietin-1 - antagonists & inhibitors Angiopoietin-1 - pharmacology Angiopoietin-1 - physiology Animals Antigens, CD - biosynthesis Antigens, CD - drug effects Antigens, CD - physiology Arterioles - drug effects Arterioles - physiology Cadherins - biosynthesis Cadherins - drug effects Cadherins - physiology Capillary Permeability - drug effects Capillary Permeability - physiology Dose-Response Relationship, Drug Endothelium eNOS Enzyme Inhibitors - pharmacology Intravital microscopy Male Mice Microcirculation Microcirculation - drug effects Microcirculation - physiology Muscle, Striated - blood supply Muscle, Striated - drug effects Muscle, Striated - physiology NG-Nitroarginine Methyl Ester - antagonists & inhibitors NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide Synthase Type III - antagonists & inhibitors Nitric Oxide Synthase Type III - physiology Phosphorylation - drug effects Signal Transduction - drug effects Signal Transduction - radiation effects Vasoconstriction - drug effects Vasoconstriction - physiology Vasodilation - drug effects Vasodilation - physiology VE-cadherin
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