Characterization of Polymer Adsorption onto Drug Nanoparticles Using Depletion Measurements and Small-Angle Neutron Scattering

Production of polymer and/or surfactant-coated crystalline nanoparticles of water-insoluble drugs (nanosuspensions) using wet bead milling is an important formulation approach to improve the bioavailability of said compounds. Despite the fact that there are a number of nanosuspensions on the market,...

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Veröffentlicht in:	Molecular pharmaceutics 2013-11, Vol.10 (11), p.4146-4158
Hauptverfasser:	Goodwin, Daniel J, Sepassi, Shadi, King, Stephen M, Holland, Simon J, Martini, Luigi G, Lawrence, M. Jayne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Hypromellose Derivatives Methylcellulose - analogs & derivatives Methylcellulose - chemistry Models, Theoretical Nanoparticles - chemistry Neutron Diffraction Polymers - chemistry Surface Properties Surface-Active Agents - chemistry
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