A role for ring-closing metathesis in medicinal chemistry: Mimicking secondary architectures in bioactive peptides

Synthetically versatile and easy to carry out, Ring‐Closing Metathesis (RCM) constitutes an attractive chemical tool, easily amenable for multiple substrates in mild conditions. In medicinal chemistry, the use of RCM has been especially prolific during the last few years. An important application th...

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Veröffentlicht in:	Medicinal research reviews 2011-09, Vol.31 (5), p.677-715
Hauptverfasser:	Pérez de Vega, María Jesús, García-Aranda, María Isabel, González-Muñiz, Rosario
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Chemistry, Pharmaceutical - methods cyclic peptides Disulfides - chemistry Hydrogen Bonding Molecular Sequence Data Peptides - chemical synthesis peptidomimetics protein secondary structures Protein Structure, Secondary protein-protein interactions ring-closing metathesis
Online-Zugang:	Volltext
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