Preconditioning With Gabexate Is Superior to Inosine for Ameliorating Acute Renal Ischemia-Reperfusion Injury in Rats

Abstract Objective The objective of this study was to compare the protease inhibitor gabexate with widely used inosine for reducing renal ischemia-reperfusion injury. Method A total of 48 rats were divided into 4 groups of 12 and administered gabexate, inosine, normal saline (NS), or nothing by inje...

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Veröffentlicht in:	Transplantation proceedings 2014, Vol.46 (1), p.40-45
Hauptverfasser:	Xie, L.-B, Zeng, D.-Y, Wang, X.-D, Lin, T, Li, Y.-P, Lu, Y.-P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - drug therapy Animals Creatinine - blood Gabexate - therapeutic use Immunohistochemistry In Situ Nick-End Labeling Inosine - therapeutic use Ischemic Preconditioning - methods Kidney - drug effects Kidney Transplantation Male Malondialdehyde - metabolism NF-kappa B - metabolism Protease Inhibitors - therapeutic use Rats Rats, Sprague-Dawley Reperfusion Injury - drug therapy Superoxide Dismutase - metabolism Surgery
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