Interstitial Cells of Cajal Modulate the Tone of the Human Internal Anal Sphincter In Vitro

BACKGROUND:Interstitial cells of Cajal, expressing the proto-oncogene c-kit, have been shown to regulate the spontaneous activity of the gastrointestinal tract. They have been described in the human internal anal sphincter; however, their function is still unclear. OBJECTIVE:We examined the effects...

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