A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells

Immune escape is a fundamental trait of cancer in which mechanistic knowledge is incomplete. Here, we describe a novel mechanism by which hypoxia contributes to tumoral immune escape from cytotoxic T lymphocytes (CTL). Exposure of human or murine cancer cells to hypoxia for 24 hours led to upregulat...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2014-02, Vol.74 (3), p.665-674
Hauptverfasser:	BARSOUM, Ivraym B, SMALLWOOD, Chelsea A, SIEMENS, D. Robert, GRAHAM, Charles H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Animals Antineoplastic agents Apoptosis - genetics Apoptosis - immunology B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Biological and medical sciences Cell Line, Tumor Cytotoxicity, Immunologic Female Gene Expression Regulation, Neoplastic - drug effects Humans Hypoxia - genetics Hypoxia - immunology Hypoxia - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Medical sciences Melanoma, Experimental Mice Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Nitroglycerin - pharmacology Pharmacology. Drug treatments Programmed Cell Death 1 Receptor - metabolism T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Tumor Escape - immunology Tumors
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