Screening of α-glucosidase inhibitors from green tea extracts using immobilized enzymes affinity capture combined with UHPLC-QTOF MS analysis

An applicable affinity capture-based method was developed for screening of enzyme inhibitors from complex plant extracts directly. By elimination of false positives, three non-competitive α-glucosidase inhibitors were fished out from 400 μL green tea extract rapidly, using affinity capture of immobi...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2014-03, Vol.50 (20), p.2582-2584
Hauptverfasser:	Deng, Shiren, Xia, Linbo, Xiao, Hongbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding, Competitive Chromatography, High Pressure Liquid Drug Evaluation, Preclinical Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes, Immobilized Glycoside Hydrolase Inhibitors Mass Spectrometry Molecular Structure Plant Extracts - metabolism Plant Extracts - pharmacology Protein Binding - drug effects Tea - chemistry
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