Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management
Autosomal-dominant polycystic kidney disease (ADPKD) is a systemic disease, marked by progressive increase of bilateral renal cysts, resulting in chronic kidney disease (CKD) and often leading to end-stage renal disease (ESRD). Apart from renal cysts, patients often have extra-renal disease, involvi...
Gespeichert in:
| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2014-02, Vol.29 (2), p.247-254 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 254 |
|---|---|
| container_issue | 2 |
| container_start_page | 247 |
| container_title | Nephrology, dialysis, transplantation |
| container_volume | 29 |
| creator | Luciano, Randy L Dahl, Neera K |
| description | Autosomal-dominant polycystic kidney disease (ADPKD) is a systemic disease, marked by progressive increase of bilateral renal cysts, resulting in chronic kidney disease (CKD) and often leading to end-stage renal disease (ESRD). Apart from renal cysts, patients often have extra-renal disease, involving the liver, heart and vasculature. Other less common but equally important extra-renal manifestations of ADPKD include diverticular disease, hernias, male infertility and pain. Extra-renal disease burden is often asymptomatic, but may result in increased morbidity and mortality. If the disease burden is significant, screening may prove beneficial. We review the rationale for current screening recommendations and propose some guidelines for screening and management of ADPKD patients. |
| doi_str_mv | 10.1093/ndt/gft437 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1499132016</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1499132016</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-88edc181507e2f5e882231a907103741506ee2ba54024b217cf55f608c2aab103</originalsourceid><addsrcrecordid>eNo9kE1OwzAQhS0EoqWw4QDIy4IUajtJ47Cr2vIjKsEC1pHrjCtDYhfbkcgJuDauWliNNO-bNzMPoUtKbikp04mpw2SjQpYWR2hIsylJWMrzYzSMIk1ITsoBOvP-gxBSsqI4RQOWMZoTyofoZ_kdnEgcGNHgVhitwAcRtDUeW4VFF6y3bdRq22ojTMBb2_Sy90FL_KlrAz2utQfhAY9ni9fnxfUdlnFa1-AOPso67GwXtAHspQMw2mywMPVuodhACyacoxMlGg8XhzpC7_fLt_ljsnp5eJrPVolMeRkSzqGWlMfjC2AqB84ZS6koSUFJWmSxPwVga5FnhGVrRgup8lxNCZdMiHVkRmi89906-9XFX6tWewlNIwzYzlc0K0uaMkKnEb3Zo9JZ7x2oaut0K1xfUVLtgq9i8NU--AhfHXy7dQv1P_qXdPoLkfqBLw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1499132016</pqid></control><display><type>article</type><title>Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Luciano, Randy L ; Dahl, Neera K</creator><creatorcontrib>Luciano, Randy L ; Dahl, Neera K</creatorcontrib><description>Autosomal-dominant polycystic kidney disease (ADPKD) is a systemic disease, marked by progressive increase of bilateral renal cysts, resulting in chronic kidney disease (CKD) and often leading to end-stage renal disease (ESRD). Apart from renal cysts, patients often have extra-renal disease, involving the liver, heart and vasculature. Other less common but equally important extra-renal manifestations of ADPKD include diverticular disease, hernias, male infertility and pain. Extra-renal disease burden is often asymptomatic, but may result in increased morbidity and mortality. If the disease burden is significant, screening may prove beneficial. We review the rationale for current screening recommendations and propose some guidelines for screening and management of ADPKD patients.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gft437</identifier><identifier>PMID: 24215018</identifier><language>eng</language><publisher>England</publisher><subject>Cardiovascular Diseases - diagnosis ; Central Nervous System Diseases - diagnosis ; Digestive System Diseases - diagnosis ; Disease Management ; Genetic Predisposition to Disease ; Genetic Testing - methods ; Global Health ; Humans ; Male ; Mass Screening - methods ; Morbidity ; Polycystic Kidney, Autosomal Dominant - diagnosis ; Polycystic Kidney, Autosomal Dominant - therapy ; Survival Rate</subject><ispartof>Nephrology, dialysis, transplantation, 2014-02, Vol.29 (2), p.247-254</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-88edc181507e2f5e882231a907103741506ee2ba54024b217cf55f608c2aab103</citedby><cites>FETCH-LOGICAL-c389t-88edc181507e2f5e882231a907103741506ee2ba54024b217cf55f608c2aab103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24215018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luciano, Randy L</creatorcontrib><creatorcontrib>Dahl, Neera K</creatorcontrib><title>Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>Autosomal-dominant polycystic kidney disease (ADPKD) is a systemic disease, marked by progressive increase of bilateral renal cysts, resulting in chronic kidney disease (CKD) and often leading to end-stage renal disease (ESRD). Apart from renal cysts, patients often have extra-renal disease, involving the liver, heart and vasculature. Other less common but equally important extra-renal manifestations of ADPKD include diverticular disease, hernias, male infertility and pain. Extra-renal disease burden is often asymptomatic, but may result in increased morbidity and mortality. If the disease burden is significant, screening may prove beneficial. We review the rationale for current screening recommendations and propose some guidelines for screening and management of ADPKD patients.</description><subject>Cardiovascular Diseases - diagnosis</subject><subject>Central Nervous System Diseases - diagnosis</subject><subject>Digestive System Diseases - diagnosis</subject><subject>Disease Management</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Testing - methods</subject><subject>Global Health</subject><subject>Humans</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Morbidity</subject><subject>Polycystic Kidney, Autosomal Dominant - diagnosis</subject><subject>Polycystic Kidney, Autosomal Dominant - therapy</subject><subject>Survival Rate</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1OwzAQhS0EoqWw4QDIy4IUajtJ47Cr2vIjKsEC1pHrjCtDYhfbkcgJuDauWliNNO-bNzMPoUtKbikp04mpw2SjQpYWR2hIsylJWMrzYzSMIk1ITsoBOvP-gxBSsqI4RQOWMZoTyofoZ_kdnEgcGNHgVhitwAcRtDUeW4VFF6y3bdRq22ojTMBb2_Sy90FL_KlrAz2utQfhAY9ni9fnxfUdlnFa1-AOPso67GwXtAHspQMw2mywMPVuodhACyacoxMlGg8XhzpC7_fLt_ljsnp5eJrPVolMeRkSzqGWlMfjC2AqB84ZS6koSUFJWmSxPwVga5FnhGVrRgup8lxNCZdMiHVkRmi89906-9XFX6tWewlNIwzYzlc0K0uaMkKnEb3Zo9JZ7x2oaut0K1xfUVLtgq9i8NU--AhfHXy7dQv1P_qXdPoLkfqBLw</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Luciano, Randy L</creator><creator>Dahl, Neera K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140201</creationdate><title>Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management</title><author>Luciano, Randy L ; Dahl, Neera K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-88edc181507e2f5e882231a907103741506ee2ba54024b217cf55f608c2aab103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Cardiovascular Diseases - diagnosis</topic><topic>Central Nervous System Diseases - diagnosis</topic><topic>Digestive System Diseases - diagnosis</topic><topic>Disease Management</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic Testing - methods</topic><topic>Global Health</topic><topic>Humans</topic><topic>Male</topic><topic>Mass Screening - methods</topic><topic>Morbidity</topic><topic>Polycystic Kidney, Autosomal Dominant - diagnosis</topic><topic>Polycystic Kidney, Autosomal Dominant - therapy</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luciano, Randy L</creatorcontrib><creatorcontrib>Dahl, Neera K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luciano, Randy L</au><au>Dahl, Neera K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>29</volume><issue>2</issue><spage>247</spage><epage>254</epage><pages>247-254</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><abstract>Autosomal-dominant polycystic kidney disease (ADPKD) is a systemic disease, marked by progressive increase of bilateral renal cysts, resulting in chronic kidney disease (CKD) and often leading to end-stage renal disease (ESRD). Apart from renal cysts, patients often have extra-renal disease, involving the liver, heart and vasculature. Other less common but equally important extra-renal manifestations of ADPKD include diverticular disease, hernias, male infertility and pain. Extra-renal disease burden is often asymptomatic, but may result in increased morbidity and mortality. If the disease burden is significant, screening may prove beneficial. We review the rationale for current screening recommendations and propose some guidelines for screening and management of ADPKD patients.</abstract><cop>England</cop><pmid>24215018</pmid><doi>10.1093/ndt/gft437</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0931-0509 |
| ispartof | Nephrology, dialysis, transplantation, 2014-02, Vol.29 (2), p.247-254 |
| issn | 0931-0509 1460-2385 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1499132016 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Cardiovascular Diseases - diagnosis Central Nervous System Diseases - diagnosis Digestive System Diseases - diagnosis Disease Management Genetic Predisposition to Disease Genetic Testing - methods Global Health Humans Male Mass Screening - methods Morbidity Polycystic Kidney, Autosomal Dominant - diagnosis Polycystic Kidney, Autosomal Dominant - therapy Survival Rate |
| title | Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T11%3A04%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Extra-renal%20manifestations%20of%20autosomal%20dominant%20polycystic%20kidney%20disease%20(ADPKD):%20considerations%20for%20routine%20screening%20and%20management&rft.jtitle=Nephrology,%20dialysis,%20transplantation&rft.au=Luciano,%20Randy%20L&rft.date=2014-02-01&rft.volume=29&rft.issue=2&rft.spage=247&rft.epage=254&rft.pages=247-254&rft.issn=0931-0509&rft.eissn=1460-2385&rft_id=info:doi/10.1093/ndt/gft437&rft_dat=%3Cproquest_cross%3E1499132016%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1499132016&rft_id=info:pmid/24215018&rfr_iscdi=true |