Structures and Absolute Configurations of Penicillactones A–C from an Endophytic Microorganism, Penicillium dangeardii Pitt

Penicillactones A–C (1–3) are structurally related natural products with a spirocyclic anhydride structure and were isolated from the endophytic fungus Penicillium dangeardii Pitt. Penicillactones B and C showed inhibition of the release of β-glucuronidase from polymorphonuclear leukocytes with ED50...

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Veröffentlicht in:	Organic letters 2013-10, Vol.15 (20), p.5206-5209
Hauptverfasser:	Liu, Yunbao, Ding, Guangzhi, Li, Yong, Qu, Jing, Ma, Shuanggang, Lv, Haining, Liu, Yang, Wang, Wenjie, Dai, Jungui, Tang, Yi, Yu, Shishan
Format:	Artikel
Sprache:	eng
Schlagworte:	Dose-Response Relationship, Drug Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Glucuronidase - antagonists & inhibitors Glucuronidase - metabolism Humans Lactones - chemistry Lactones - isolation & purification Models, Molecular Molecular Structure Neutrophils - enzymology Neutrophils - metabolism Penicillium - chemistry Spiro Compounds - chemistry Spiro Compounds - isolation & purification Stereoisomerism Structure-Activity Relationship
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