Long-Term Outcomes of Endovascular Therapy for Aortoiliac Bifurcation Lesions in the Real-AI Registry
Purpose To report long-term outcomes of endovascular therapy (EVT) for aortoiliac bifurcation lesions. Methods Patients enrolled in the multicenter REtrospective AnaLysis of Aorto-Iliac stenting (REAL-AI) registry in Japan were pooled. Of 2096 patients who underwent EVT for de novo aortoiliac diseas...
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| Veröffentlicht in: | Journal of endovascular therapy 2014-02, Vol.21 (1), p.25-33 |
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| creator | Aihara, Hideaki Soga, Yoshimitsu Iida, Osamu Suzuki, Kenji Tazaki, Junichi Shintani, Yoshiaki Miyashita, Yusuke |
| description | Purpose
To report long-term outcomes of endovascular therapy (EVT) for aortoiliac
bifurcation lesions.
Methods
Patients enrolled in the multicenter REtrospective AnaLysis of Aorto-Iliac
stenting (REAL-AI) registry in Japan were pooled. Of 2096 patients who
underwent EVT for de novo aortoiliac disease between January 2005 and
December 2009, 190 patients (148 men; mean age 70±9 years) had
aortoiliac bifurcation lesions that were treated with stents, whose
configuration (single, V, or kissing) and type (balloon-expandable or
self-expanding) were subjected to regression analysis to determine any
impact on primary patency along with other demographic, clinical, and lesion
characteristics, including Trans-Atlantic Inter-Society Consensus II C/D
classification. The primary endpoints were restenosis and target lesion
revascularization (TLR). Secondary endpoints were all-cause death, major
cardiovascular events, and major cardiovascular + limb events.
Results
The overall complication rate was 6.3%, and 1- and 5-year primary
patency rates were 87% and 73%, respectively. Over a mean
follow-up of 31±15 months, there were 36 (19.0%) restenoses,
22 (11.6%) TLRs, and 4 (2.1%) reocclusions; stent fracture (2,
1.1%) and major amputation (2, 1.1%) were rare. Only female
gender [adjusted hazard ratio (AHR) 4.26, 95% CI 1.89 to 9.71,
p |
| doi_str_mv | 10.1583/13-4410MR.1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1499131241</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1583_13-4410MR.1</sage_id><sourcerecordid>3234745541</sourcerecordid><originalsourceid>FETCH-LOGICAL-c416t-817b35a475c1b394791b7bc3d72673e3a44965153a489f6178bf6233de5e22693</originalsourceid><addsrcrecordid>eNptkEtLw0AUhQdRfK_cy4AbQaJz55VkWcUXVAqlrofJ9KZGkkydSYT-e1PqC3F1zuLju5dDyAmwS1CZuAKRSAnsaXoJW2QflFQJKMW2153rRDOe7ZGDGF8Z48ABdskel4pxmcE-wbFvF8kMQ0Mnfed8g5H6kt62c_9uo-trG-jsBYNdrmjpAx350Pmqrqyj11XZB2e7yrd0jHGISKuWdi9Ip2jrZPQ45KKKXVgdkZ3S1hGPP_OQPN_dzm4ekvHk_vFmNE6cBN0lGaSFUFamykEhcpnmUKSFE_OU61SgsFLmWoEaSpaXGtKsKDUXYo4KOde5OCTnG-8y-LceY2eaKjqsa9ui76MBmecggEsY0LM_6KvvQzt8Z0AxobXQSg3UxYZywccYsDTLUDU2rAwws17fgDCb9c3aefrp7IsG59_s19w__0W7wF8H_3F9AN-UiW0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1503663655</pqid></control><display><type>article</type><title>Long-Term Outcomes of Endovascular Therapy for Aortoiliac Bifurcation Lesions in the Real-AI Registry</title><source>MEDLINE</source><source>SAGE Complete</source><creator>Aihara, Hideaki ; Soga, Yoshimitsu ; Iida, Osamu ; Suzuki, Kenji ; Tazaki, Junichi ; Shintani, Yoshiaki ; Miyashita, Yusuke</creator><creatorcontrib>Aihara, Hideaki ; Soga, Yoshimitsu ; Iida, Osamu ; Suzuki, Kenji ; Tazaki, Junichi ; Shintani, Yoshiaki ; Miyashita, Yusuke ; REAL-AI Registry Investigators ; on behalf of the REAL-AI Registry Investigators</creatorcontrib><description>Purpose
To report long-term outcomes of endovascular therapy (EVT) for aortoiliac
bifurcation lesions.
Methods
Patients enrolled in the multicenter REtrospective AnaLysis of Aorto-Iliac
stenting (REAL-AI) registry in Japan were pooled. Of 2096 patients who
underwent EVT for de novo aortoiliac disease between January 2005 and
December 2009, 190 patients (148 men; mean age 70±9 years) had
aortoiliac bifurcation lesions that were treated with stents, whose
configuration (single, V, or kissing) and type (balloon-expandable or
self-expanding) were subjected to regression analysis to determine any
impact on primary patency along with other demographic, clinical, and lesion
characteristics, including Trans-Atlantic Inter-Society Consensus II C/D
classification. The primary endpoints were restenosis and target lesion
revascularization (TLR). Secondary endpoints were all-cause death, major
cardiovascular events, and major cardiovascular + limb events.
Results
The overall complication rate was 6.3%, and 1- and 5-year primary
patency rates were 87% and 73%, respectively. Over a mean
follow-up of 31±15 months, there were 36 (19.0%) restenoses,
22 (11.6%) TLRs, and 4 (2.1%) reocclusions; stent fracture (2,
1.1%) and major amputation (2, 1.1%) were rare. Only female
gender [adjusted hazard ratio (AHR) 4.26, 95% CI 1.89 to 9.71,
p<0.001] and residual diameter stenosis (AHR 1.04, 96% CI 1.01
to 1.06, p=0.01) were independent predictors of primary patency.
Conclusion
Stenting for aortoiliac bifurcation lesions was found to be safe and
effective. Neither stent configuration nor type appeared to affect vessel
patency in true bifurcation lesions.</description><identifier>ISSN: 1526-6028</identifier><identifier>EISSN: 1545-1550</identifier><identifier>DOI: 10.1583/13-4410MR.1</identifier><identifier>PMID: 24502481</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Aged ; Amputation ; Angioplasty ; Angioplasty, Balloon - adverse effects ; Angioplasty, Balloon - instrumentation ; Angioplasty, Balloon - mortality ; Aortic Diseases - diagnosis ; Aortic Diseases - mortality ; Aortic Diseases - physiopathology ; Aortic Diseases - therapy ; Arterial Occlusive Diseases - diagnosis ; Arterial Occlusive Diseases - mortality ; Arterial Occlusive Diseases - physiopathology ; Arterial Occlusive Diseases - therapy ; Cardiovascular disease ; Confidence intervals ; Constriction, Pathologic ; Female ; Heart attacks ; Humans ; Iliac Artery - physiopathology ; Japan ; Kaplan-Meier Estimate ; Limb Salvage ; Male ; Methods ; Middle Aged ; Physicians ; Prosthesis Design ; Recurrence ; Registries ; Retrospective Studies ; Risk Factors ; Stents ; Studies ; Success ; Time Factors ; Treatment Outcome ; Vascular Patency</subject><ispartof>Journal of endovascular therapy, 2014-02, Vol.21 (1), p.25-33</ispartof><rights>2014 International Society of Endovascular Specialists</rights><rights>Copyright Allen Press Publishing Services Feb 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-817b35a475c1b394791b7bc3d72673e3a44965153a489f6178bf6233de5e22693</citedby><cites>FETCH-LOGICAL-c416t-817b35a475c1b394791b7bc3d72673e3a44965153a489f6178bf6233de5e22693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1583/13-4410MR.1$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1583/13-4410MR.1$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24502481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aihara, Hideaki</creatorcontrib><creatorcontrib>Soga, Yoshimitsu</creatorcontrib><creatorcontrib>Iida, Osamu</creatorcontrib><creatorcontrib>Suzuki, Kenji</creatorcontrib><creatorcontrib>Tazaki, Junichi</creatorcontrib><creatorcontrib>Shintani, Yoshiaki</creatorcontrib><creatorcontrib>Miyashita, Yusuke</creatorcontrib><creatorcontrib>REAL-AI Registry Investigators</creatorcontrib><creatorcontrib>on behalf of the REAL-AI Registry Investigators</creatorcontrib><title>Long-Term Outcomes of Endovascular Therapy for Aortoiliac Bifurcation Lesions in the Real-AI Registry</title><title>Journal of endovascular therapy</title><addtitle>J Endovasc Ther</addtitle><description>Purpose
To report long-term outcomes of endovascular therapy (EVT) for aortoiliac
bifurcation lesions.
Methods
Patients enrolled in the multicenter REtrospective AnaLysis of Aorto-Iliac
stenting (REAL-AI) registry in Japan were pooled. Of 2096 patients who
underwent EVT for de novo aortoiliac disease between January 2005 and
December 2009, 190 patients (148 men; mean age 70±9 years) had
aortoiliac bifurcation lesions that were treated with stents, whose
configuration (single, V, or kissing) and type (balloon-expandable or
self-expanding) were subjected to regression analysis to determine any
impact on primary patency along with other demographic, clinical, and lesion
characteristics, including Trans-Atlantic Inter-Society Consensus II C/D
classification. The primary endpoints were restenosis and target lesion
revascularization (TLR). Secondary endpoints were all-cause death, major
cardiovascular events, and major cardiovascular + limb events.
Results
The overall complication rate was 6.3%, and 1- and 5-year primary
patency rates were 87% and 73%, respectively. Over a mean
follow-up of 31±15 months, there were 36 (19.0%) restenoses,
22 (11.6%) TLRs, and 4 (2.1%) reocclusions; stent fracture (2,
1.1%) and major amputation (2, 1.1%) were rare. Only female
gender [adjusted hazard ratio (AHR) 4.26, 95% CI 1.89 to 9.71,
p<0.001] and residual diameter stenosis (AHR 1.04, 96% CI 1.01
to 1.06, p=0.01) were independent predictors of primary patency.
Conclusion
Stenting for aortoiliac bifurcation lesions was found to be safe and
effective. Neither stent configuration nor type appeared to affect vessel
patency in true bifurcation lesions.</description><subject>Aged</subject><subject>Amputation</subject><subject>Angioplasty</subject><subject>Angioplasty, Balloon - adverse effects</subject><subject>Angioplasty, Balloon - instrumentation</subject><subject>Angioplasty, Balloon - mortality</subject><subject>Aortic Diseases - diagnosis</subject><subject>Aortic Diseases - mortality</subject><subject>Aortic Diseases - physiopathology</subject><subject>Aortic Diseases - therapy</subject><subject>Arterial Occlusive Diseases - diagnosis</subject><subject>Arterial Occlusive Diseases - mortality</subject><subject>Arterial Occlusive Diseases - physiopathology</subject><subject>Arterial Occlusive Diseases - therapy</subject><subject>Cardiovascular disease</subject><subject>Confidence intervals</subject><subject>Constriction, Pathologic</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Iliac Artery - physiopathology</subject><subject>Japan</subject><subject>Kaplan-Meier Estimate</subject><subject>Limb Salvage</subject><subject>Male</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Physicians</subject><subject>Prosthesis Design</subject><subject>Recurrence</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Stents</subject><subject>Studies</subject><subject>Success</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vascular Patency</subject><issn>1526-6028</issn><issn>1545-1550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkEtLw0AUhQdRfK_cy4AbQaJz55VkWcUXVAqlrofJ9KZGkkydSYT-e1PqC3F1zuLju5dDyAmwS1CZuAKRSAnsaXoJW2QflFQJKMW2153rRDOe7ZGDGF8Z48ABdskel4pxmcE-wbFvF8kMQ0Mnfed8g5H6kt62c_9uo-trG-jsBYNdrmjpAx350Pmqrqyj11XZB2e7yrd0jHGISKuWdi9Ip2jrZPQ45KKKXVgdkZ3S1hGPP_OQPN_dzm4ekvHk_vFmNE6cBN0lGaSFUFamykEhcpnmUKSFE_OU61SgsFLmWoEaSpaXGtKsKDUXYo4KOde5OCTnG-8y-LceY2eaKjqsa9ui76MBmecggEsY0LM_6KvvQzt8Z0AxobXQSg3UxYZywccYsDTLUDU2rAwws17fgDCb9c3aefrp7IsG59_s19w__0W7wF8H_3F9AN-UiW0</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Aihara, Hideaki</creator><creator>Soga, Yoshimitsu</creator><creator>Iida, Osamu</creator><creator>Suzuki, Kenji</creator><creator>Tazaki, Junichi</creator><creator>Shintani, Yoshiaki</creator><creator>Miyashita, Yusuke</creator><general>SAGE Publications</general><general>Allen Press Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>201402</creationdate><title>Long-Term Outcomes of Endovascular Therapy for Aortoiliac Bifurcation Lesions in the Real-AI Registry</title><author>Aihara, Hideaki ; Soga, Yoshimitsu ; Iida, Osamu ; Suzuki, Kenji ; Tazaki, Junichi ; Shintani, Yoshiaki ; Miyashita, Yusuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-817b35a475c1b394791b7bc3d72673e3a44965153a489f6178bf6233de5e22693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Amputation</topic><topic>Angioplasty</topic><topic>Angioplasty, Balloon - adverse effects</topic><topic>Angioplasty, Balloon - instrumentation</topic><topic>Angioplasty, Balloon - mortality</topic><topic>Aortic Diseases - diagnosis</topic><topic>Aortic Diseases - mortality</topic><topic>Aortic Diseases - physiopathology</topic><topic>Aortic Diseases - therapy</topic><topic>Arterial Occlusive Diseases - diagnosis</topic><topic>Arterial Occlusive Diseases - mortality</topic><topic>Arterial Occlusive Diseases - physiopathology</topic><topic>Arterial Occlusive Diseases - therapy</topic><topic>Cardiovascular disease</topic><topic>Confidence intervals</topic><topic>Constriction, Pathologic</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Iliac Artery - physiopathology</topic><topic>Japan</topic><topic>Kaplan-Meier Estimate</topic><topic>Limb Salvage</topic><topic>Male</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Physicians</topic><topic>Prosthesis Design</topic><topic>Recurrence</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Stents</topic><topic>Studies</topic><topic>Success</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vascular Patency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aihara, Hideaki</creatorcontrib><creatorcontrib>Soga, Yoshimitsu</creatorcontrib><creatorcontrib>Iida, Osamu</creatorcontrib><creatorcontrib>Suzuki, Kenji</creatorcontrib><creatorcontrib>Tazaki, Junichi</creatorcontrib><creatorcontrib>Shintani, Yoshiaki</creatorcontrib><creatorcontrib>Miyashita, Yusuke</creatorcontrib><creatorcontrib>REAL-AI Registry Investigators</creatorcontrib><creatorcontrib>on behalf of the REAL-AI Registry Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endovascular therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aihara, Hideaki</au><au>Soga, Yoshimitsu</au><au>Iida, Osamu</au><au>Suzuki, Kenji</au><au>Tazaki, Junichi</au><au>Shintani, Yoshiaki</au><au>Miyashita, Yusuke</au><aucorp>REAL-AI Registry Investigators</aucorp><aucorp>on behalf of the REAL-AI Registry Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term Outcomes of Endovascular Therapy for Aortoiliac Bifurcation Lesions in the Real-AI Registry</atitle><jtitle>Journal of endovascular therapy</jtitle><addtitle>J Endovasc Ther</addtitle><date>2014-02</date><risdate>2014</risdate><volume>21</volume><issue>1</issue><spage>25</spage><epage>33</epage><pages>25-33</pages><issn>1526-6028</issn><eissn>1545-1550</eissn><abstract>Purpose
To report long-term outcomes of endovascular therapy (EVT) for aortoiliac
bifurcation lesions.
Methods
Patients enrolled in the multicenter REtrospective AnaLysis of Aorto-Iliac
stenting (REAL-AI) registry in Japan were pooled. Of 2096 patients who
underwent EVT for de novo aortoiliac disease between January 2005 and
December 2009, 190 patients (148 men; mean age 70±9 years) had
aortoiliac bifurcation lesions that were treated with stents, whose
configuration (single, V, or kissing) and type (balloon-expandable or
self-expanding) were subjected to regression analysis to determine any
impact on primary patency along with other demographic, clinical, and lesion
characteristics, including Trans-Atlantic Inter-Society Consensus II C/D
classification. The primary endpoints were restenosis and target lesion
revascularization (TLR). Secondary endpoints were all-cause death, major
cardiovascular events, and major cardiovascular + limb events.
Results
The overall complication rate was 6.3%, and 1- and 5-year primary
patency rates were 87% and 73%, respectively. Over a mean
follow-up of 31±15 months, there were 36 (19.0%) restenoses,
22 (11.6%) TLRs, and 4 (2.1%) reocclusions; stent fracture (2,
1.1%) and major amputation (2, 1.1%) were rare. Only female
gender [adjusted hazard ratio (AHR) 4.26, 95% CI 1.89 to 9.71,
p<0.001] and residual diameter stenosis (AHR 1.04, 96% CI 1.01
to 1.06, p=0.01) were independent predictors of primary patency.
Conclusion
Stenting for aortoiliac bifurcation lesions was found to be safe and
effective. Neither stent configuration nor type appeared to affect vessel
patency in true bifurcation lesions.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>24502481</pmid><doi>10.1583/13-4410MR.1</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1526-6028 |
| ispartof | Journal of endovascular therapy, 2014-02, Vol.21 (1), p.25-33 |
| issn | 1526-6028 1545-1550 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1499131241 |
| source | MEDLINE; SAGE Complete |
| subjects | Aged Amputation Angioplasty Angioplasty, Balloon - adverse effects Angioplasty, Balloon - instrumentation Angioplasty, Balloon - mortality Aortic Diseases - diagnosis Aortic Diseases - mortality Aortic Diseases - physiopathology Aortic Diseases - therapy Arterial Occlusive Diseases - diagnosis Arterial Occlusive Diseases - mortality Arterial Occlusive Diseases - physiopathology Arterial Occlusive Diseases - therapy Cardiovascular disease Confidence intervals Constriction, Pathologic Female Heart attacks Humans Iliac Artery - physiopathology Japan Kaplan-Meier Estimate Limb Salvage Male Methods Middle Aged Physicians Prosthesis Design Recurrence Registries Retrospective Studies Risk Factors Stents Studies Success Time Factors Treatment Outcome Vascular Patency |
| title | Long-Term Outcomes of Endovascular Therapy for Aortoiliac Bifurcation Lesions in the Real-AI Registry |
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