Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling
•ECR between M. musculus and H. sapiense, contains putative TCF/LEFs binding elements.•Wnt/β-catenin signaling regulates TLE3 expression in bone marrow stromal cells.•TLE3 suppresses Wnt/β-catenin signaling in bone marrow stromal cells. Transducing-like enhancer of split 3 (TLE3), one of the Groucho...
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Veröffentlicht in: | FEBS letters 2014-02, Vol.588 (4), p.614-619 |
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creator | Kokabu, Shoichiro Sato, Tsuyoshi Ohte, Satoshi Enoki, Yuichiro Okubo, Masahiko Hayashi, Naoki Nojima, Junya Tsukamoto, Sho Fukushima, Yosuke Sakata, Yasuaki Katagiri, Takenobu Rosen, Vicki Yoda, Tetsuya |
description | •ECR between M. musculus and H. sapiense, contains putative TCF/LEFs binding elements.•Wnt/β-catenin signaling regulates TLE3 expression in bone marrow stromal cells.•TLE3 suppresses Wnt/β-catenin signaling in bone marrow stromal cells.
Transducing-like enhancer of split 3 (TLE3), one of the Groucho/TLE family members, targets Runx2 transcription and suppresses osteoblast differentiation in bone marrow stromal cells (BMSCs). Here, we identify Wnt responsive elements of the TLE3 promoter region through comparative genomic and functional analyses and show that expression of TLE3 is increased by Wnt signaling, which is important for osteoblast differentiation. We also demonstrated that TLE3 is able to suppress canonical Wnt signaling in BMSCs. Taken together, our data suggest that induction of TLE3 by Wnt signaling is part of a negative feedback loop active during osteoblast differentiation. |
doi_str_mv | 10.1016/j.febslet.2013.12.031 |
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Transducing-like enhancer of split 3 (TLE3), one of the Groucho/TLE family members, targets Runx2 transcription and suppresses osteoblast differentiation in bone marrow stromal cells (BMSCs). Here, we identify Wnt responsive elements of the TLE3 promoter region through comparative genomic and functional analyses and show that expression of TLE3 is increased by Wnt signaling, which is important for osteoblast differentiation. We also demonstrated that TLE3 is able to suppress canonical Wnt signaling in BMSCs. Taken together, our data suggest that induction of TLE3 by Wnt signaling is part of a negative feedback loop active during osteoblast differentiation.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2013.12.031</identifier><identifier>PMID: 24444608</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>alkaline phosphatase ; ALP ; Animals ; Base Sequence ; beta Catenin - metabolism ; Binding Sites ; BMP ; BMSC ; bone marrow stromal cell ; bone morphogenetic protein ; C/EBP ; CCAAT/enhancer-binding protein ; Cell Differentiation ; Cell Line ; Co-repressor ; Co-Repressor Proteins - genetics ; Conserved Sequence ; Gene Expression Regulation ; Genomics ; Groucho ; Humans ; Mesenchymal Stromal Cells - cytology ; Mesenchymal Stromal Cells - metabolism ; Mice ; Molecular Sequence Data ; Osteoblastogenesis ; Osteoblasts - cytology ; Osteocalcin ; Osteoporosis ; PPARγ ; proliferator-activated receptor γ ; Response Elements - genetics ; Signal Transduction ; TLE ; Transducing-like enhancer of split ; Wnt ; Wnt Proteins - metabolism</subject><ispartof>FEBS letters, 2014-02, Vol.588 (4), p.614-619</ispartof><rights>2014 Federation of European Biochemical Societies</rights><rights>FEBS Letters 588 (2014) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4965-a53cf808dd1b0f6a9363ba36f1acf770677c7c0353b6d07de273bc4f881480d73</citedby><cites>FETCH-LOGICAL-c4965-a53cf808dd1b0f6a9363ba36f1acf770677c7c0353b6d07de273bc4f881480d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2013.12.031$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.febslet.2013.12.031$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,1433,3550,27924,27925,45574,45575,45995,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24444608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kokabu, Shoichiro</creatorcontrib><creatorcontrib>Sato, Tsuyoshi</creatorcontrib><creatorcontrib>Ohte, Satoshi</creatorcontrib><creatorcontrib>Enoki, Yuichiro</creatorcontrib><creatorcontrib>Okubo, Masahiko</creatorcontrib><creatorcontrib>Hayashi, Naoki</creatorcontrib><creatorcontrib>Nojima, Junya</creatorcontrib><creatorcontrib>Tsukamoto, Sho</creatorcontrib><creatorcontrib>Fukushima, Yosuke</creatorcontrib><creatorcontrib>Sakata, Yasuaki</creatorcontrib><creatorcontrib>Katagiri, Takenobu</creatorcontrib><creatorcontrib>Rosen, Vicki</creatorcontrib><creatorcontrib>Yoda, Tetsuya</creatorcontrib><title>Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>•ECR between M. musculus and H. sapiense, contains putative TCF/LEFs binding elements.•Wnt/β-catenin signaling regulates TLE3 expression in bone marrow stromal cells.•TLE3 suppresses Wnt/β-catenin signaling in bone marrow stromal cells.
Transducing-like enhancer of split 3 (TLE3), one of the Groucho/TLE family members, targets Runx2 transcription and suppresses osteoblast differentiation in bone marrow stromal cells (BMSCs). Here, we identify Wnt responsive elements of the TLE3 promoter region through comparative genomic and functional analyses and show that expression of TLE3 is increased by Wnt signaling, which is important for osteoblast differentiation. We also demonstrated that TLE3 is able to suppress canonical Wnt signaling in BMSCs. Taken together, our data suggest that induction of TLE3 by Wnt signaling is part of a negative feedback loop active during osteoblast differentiation.</description><subject>alkaline phosphatase</subject><subject>ALP</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>beta Catenin - metabolism</subject><subject>Binding Sites</subject><subject>BMP</subject><subject>BMSC</subject><subject>bone marrow stromal cell</subject><subject>bone morphogenetic protein</subject><subject>C/EBP</subject><subject>CCAAT/enhancer-binding protein</subject><subject>Cell Differentiation</subject><subject>Cell Line</subject><subject>Co-repressor</subject><subject>Co-Repressor Proteins - genetics</subject><subject>Conserved Sequence</subject><subject>Gene Expression Regulation</subject><subject>Genomics</subject><subject>Groucho</subject><subject>Humans</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - metabolism</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Osteoblastogenesis</subject><subject>Osteoblasts - cytology</subject><subject>Osteocalcin</subject><subject>Osteoporosis</subject><subject>PPARγ</subject><subject>proliferator-activated receptor γ</subject><subject>Response Elements - genetics</subject><subject>Signal Transduction</subject><subject>TLE</subject><subject>Transducing-like enhancer of split</subject><subject>Wnt</subject><subject>Wnt Proteins - metabolism</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFvGyEQhVHVqnHS_oRWHHvZDSy7wJ6q1HKSSpZ6aKocEQuDhbUGF9ZJ_e_Lym6uDZcR4s1j5nsIfaKkpoTy623tYMgjTHVDKKtpUxNG36AFlYJVrOXyLVoQQtuqEz27QJc5b0m5S9q_RxdNWw4ncoEeV3_2CXL2MeDo8MN6xfBwxEMMgHc6pfiM85TiTo_YwDhm7DNOsDmMegI7K40OMXhT3h_DhLPfBD36sPmA3jk9Zvh4rlfo1-3qYXlfrX_cfV_erCvT9ryrdMeMk0RaSwfiuO4ZZ4Nm3FFtnBCEC2GEIaxjA7dEWGgEG0zrpKStJFawK_Tl5LtP8fcB8qR2Ps-T6gDxkBVt-56yYtAUaXeSmhRzTuDUPvmy41FRomamaqvOTNXMVNFGFaal7_P5i8OwA_vS9Q9iEdyfBM9-hOPrXNXt6lvzcw5ozoe2JZum74rV15MVFGZPHpLKxkMwYH0CMykb_X-m_Qtybp97</recordid><startdate>20140214</startdate><enddate>20140214</enddate><creator>Kokabu, Shoichiro</creator><creator>Sato, Tsuyoshi</creator><creator>Ohte, Satoshi</creator><creator>Enoki, Yuichiro</creator><creator>Okubo, Masahiko</creator><creator>Hayashi, Naoki</creator><creator>Nojima, Junya</creator><creator>Tsukamoto, Sho</creator><creator>Fukushima, Yosuke</creator><creator>Sakata, Yasuaki</creator><creator>Katagiri, Takenobu</creator><creator>Rosen, Vicki</creator><creator>Yoda, Tetsuya</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140214</creationdate><title>Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling</title><author>Kokabu, Shoichiro ; Sato, Tsuyoshi ; Ohte, Satoshi ; Enoki, Yuichiro ; Okubo, Masahiko ; Hayashi, Naoki ; Nojima, Junya ; Tsukamoto, Sho ; Fukushima, Yosuke ; Sakata, Yasuaki ; Katagiri, Takenobu ; Rosen, Vicki ; Yoda, Tetsuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4965-a53cf808dd1b0f6a9363ba36f1acf770677c7c0353b6d07de273bc4f881480d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>alkaline phosphatase</topic><topic>ALP</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>beta Catenin - metabolism</topic><topic>Binding Sites</topic><topic>BMP</topic><topic>BMSC</topic><topic>bone marrow stromal cell</topic><topic>bone morphogenetic protein</topic><topic>C/EBP</topic><topic>CCAAT/enhancer-binding protein</topic><topic>Cell Differentiation</topic><topic>Cell Line</topic><topic>Co-repressor</topic><topic>Co-Repressor Proteins - genetics</topic><topic>Conserved Sequence</topic><topic>Gene Expression Regulation</topic><topic>Genomics</topic><topic>Groucho</topic><topic>Humans</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Mesenchymal Stromal Cells - metabolism</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Osteoblastogenesis</topic><topic>Osteoblasts - cytology</topic><topic>Osteocalcin</topic><topic>Osteoporosis</topic><topic>PPARγ</topic><topic>proliferator-activated receptor γ</topic><topic>Response Elements - genetics</topic><topic>Signal Transduction</topic><topic>TLE</topic><topic>Transducing-like enhancer of split</topic><topic>Wnt</topic><topic>Wnt Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kokabu, Shoichiro</creatorcontrib><creatorcontrib>Sato, Tsuyoshi</creatorcontrib><creatorcontrib>Ohte, Satoshi</creatorcontrib><creatorcontrib>Enoki, Yuichiro</creatorcontrib><creatorcontrib>Okubo, Masahiko</creatorcontrib><creatorcontrib>Hayashi, Naoki</creatorcontrib><creatorcontrib>Nojima, Junya</creatorcontrib><creatorcontrib>Tsukamoto, Sho</creatorcontrib><creatorcontrib>Fukushima, Yosuke</creatorcontrib><creatorcontrib>Sakata, Yasuaki</creatorcontrib><creatorcontrib>Katagiri, Takenobu</creatorcontrib><creatorcontrib>Rosen, Vicki</creatorcontrib><creatorcontrib>Yoda, Tetsuya</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kokabu, Shoichiro</au><au>Sato, Tsuyoshi</au><au>Ohte, Satoshi</au><au>Enoki, Yuichiro</au><au>Okubo, Masahiko</au><au>Hayashi, Naoki</au><au>Nojima, Junya</au><au>Tsukamoto, Sho</au><au>Fukushima, Yosuke</au><au>Sakata, Yasuaki</au><au>Katagiri, Takenobu</au><au>Rosen, Vicki</au><au>Yoda, Tetsuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2014-02-14</date><risdate>2014</risdate><volume>588</volume><issue>4</issue><spage>614</spage><epage>619</epage><pages>614-619</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>•ECR between M. musculus and H. sapiense, contains putative TCF/LEFs binding elements.•Wnt/β-catenin signaling regulates TLE3 expression in bone marrow stromal cells.•TLE3 suppresses Wnt/β-catenin signaling in bone marrow stromal cells.
Transducing-like enhancer of split 3 (TLE3), one of the Groucho/TLE family members, targets Runx2 transcription and suppresses osteoblast differentiation in bone marrow stromal cells (BMSCs). Here, we identify Wnt responsive elements of the TLE3 promoter region through comparative genomic and functional analyses and show that expression of TLE3 is increased by Wnt signaling, which is important for osteoblast differentiation. We also demonstrated that TLE3 is able to suppress canonical Wnt signaling in BMSCs. Taken together, our data suggest that induction of TLE3 by Wnt signaling is part of a negative feedback loop active during osteoblast differentiation.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>24444608</pmid><doi>10.1016/j.febslet.2013.12.031</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | alkaline phosphatase ALP Animals Base Sequence beta Catenin - metabolism Binding Sites BMP BMSC bone marrow stromal cell bone morphogenetic protein C/EBP CCAAT/enhancer-binding protein Cell Differentiation Cell Line Co-repressor Co-Repressor Proteins - genetics Conserved Sequence Gene Expression Regulation Genomics Groucho Humans Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mice Molecular Sequence Data Osteoblastogenesis Osteoblasts - cytology Osteocalcin Osteoporosis PPARγ proliferator-activated receptor γ Response Elements - genetics Signal Transduction TLE Transducing-like enhancer of split Wnt Wnt Proteins - metabolism |
title | Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling |
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