Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling

•ECR between M. musculus and H. sapiense, contains putative TCF/LEFs binding elements.•Wnt/β-catenin signaling regulates TLE3 expression in bone marrow stromal cells.•TLE3 suppresses Wnt/β-catenin signaling in bone marrow stromal cells. Transducing-like enhancer of split 3 (TLE3), one of the Groucho...

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Veröffentlicht in:FEBS letters 2014-02, Vol.588 (4), p.614-619
Hauptverfasser: Kokabu, Shoichiro, Sato, Tsuyoshi, Ohte, Satoshi, Enoki, Yuichiro, Okubo, Masahiko, Hayashi, Naoki, Nojima, Junya, Tsukamoto, Sho, Fukushima, Yosuke, Sakata, Yasuaki, Katagiri, Takenobu, Rosen, Vicki, Yoda, Tetsuya
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container_end_page 619
container_issue 4
container_start_page 614
container_title FEBS letters
container_volume 588
creator Kokabu, Shoichiro
Sato, Tsuyoshi
Ohte, Satoshi
Enoki, Yuichiro
Okubo, Masahiko
Hayashi, Naoki
Nojima, Junya
Tsukamoto, Sho
Fukushima, Yosuke
Sakata, Yasuaki
Katagiri, Takenobu
Rosen, Vicki
Yoda, Tetsuya
description •ECR between M. musculus and H. sapiense, contains putative TCF/LEFs binding elements.•Wnt/β-catenin signaling regulates TLE3 expression in bone marrow stromal cells.•TLE3 suppresses Wnt/β-catenin signaling in bone marrow stromal cells. Transducing-like enhancer of split 3 (TLE3), one of the Groucho/TLE family members, targets Runx2 transcription and suppresses osteoblast differentiation in bone marrow stromal cells (BMSCs). Here, we identify Wnt responsive elements of the TLE3 promoter region through comparative genomic and functional analyses and show that expression of TLE3 is increased by Wnt signaling, which is important for osteoblast differentiation. We also demonstrated that TLE3 is able to suppress canonical Wnt signaling in BMSCs. Taken together, our data suggest that induction of TLE3 by Wnt signaling is part of a negative feedback loop active during osteoblast differentiation.
doi_str_mv 10.1016/j.febslet.2013.12.031
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Transducing-like enhancer of split 3 (TLE3), one of the Groucho/TLE family members, targets Runx2 transcription and suppresses osteoblast differentiation in bone marrow stromal cells (BMSCs). Here, we identify Wnt responsive elements of the TLE3 promoter region through comparative genomic and functional analyses and show that expression of TLE3 is increased by Wnt signaling, which is important for osteoblast differentiation. We also demonstrated that TLE3 is able to suppress canonical Wnt signaling in BMSCs. 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Transducing-like enhancer of split 3 (TLE3), one of the Groucho/TLE family members, targets Runx2 transcription and suppresses osteoblast differentiation in bone marrow stromal cells (BMSCs). Here, we identify Wnt responsive elements of the TLE3 promoter region through comparative genomic and functional analyses and show that expression of TLE3 is increased by Wnt signaling, which is important for osteoblast differentiation. We also demonstrated that TLE3 is able to suppress canonical Wnt signaling in BMSCs. 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Sato, Tsuyoshi ; Ohte, Satoshi ; Enoki, Yuichiro ; Okubo, Masahiko ; Hayashi, Naoki ; Nojima, Junya ; Tsukamoto, Sho ; Fukushima, Yosuke ; Sakata, Yasuaki ; Katagiri, Takenobu ; Rosen, Vicki ; Yoda, Tetsuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4965-a53cf808dd1b0f6a9363ba36f1acf770677c7c0353b6d07de273bc4f881480d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>alkaline phosphatase</topic><topic>ALP</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>beta Catenin - metabolism</topic><topic>Binding Sites</topic><topic>BMP</topic><topic>BMSC</topic><topic>bone marrow stromal cell</topic><topic>bone morphogenetic protein</topic><topic>C/EBP</topic><topic>CCAAT/enhancer-binding protein</topic><topic>Cell Differentiation</topic><topic>Cell Line</topic><topic>Co-repressor</topic><topic>Co-Repressor Proteins - genetics</topic><topic>Conserved Sequence</topic><topic>Gene Expression Regulation</topic><topic>Genomics</topic><topic>Groucho</topic><topic>Humans</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Mesenchymal Stromal Cells - metabolism</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Osteoblastogenesis</topic><topic>Osteoblasts - cytology</topic><topic>Osteocalcin</topic><topic>Osteoporosis</topic><topic>PPARγ</topic><topic>proliferator-activated receptor γ</topic><topic>Response Elements - genetics</topic><topic>Signal Transduction</topic><topic>TLE</topic><topic>Transducing-like enhancer of split</topic><topic>Wnt</topic><topic>Wnt Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kokabu, Shoichiro</creatorcontrib><creatorcontrib>Sato, Tsuyoshi</creatorcontrib><creatorcontrib>Ohte, Satoshi</creatorcontrib><creatorcontrib>Enoki, Yuichiro</creatorcontrib><creatorcontrib>Okubo, Masahiko</creatorcontrib><creatorcontrib>Hayashi, Naoki</creatorcontrib><creatorcontrib>Nojima, Junya</creatorcontrib><creatorcontrib>Tsukamoto, Sho</creatorcontrib><creatorcontrib>Fukushima, Yosuke</creatorcontrib><creatorcontrib>Sakata, Yasuaki</creatorcontrib><creatorcontrib>Katagiri, Takenobu</creatorcontrib><creatorcontrib>Rosen, Vicki</creatorcontrib><creatorcontrib>Yoda, Tetsuya</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kokabu, Shoichiro</au><au>Sato, Tsuyoshi</au><au>Ohte, Satoshi</au><au>Enoki, Yuichiro</au><au>Okubo, Masahiko</au><au>Hayashi, Naoki</au><au>Nojima, Junya</au><au>Tsukamoto, Sho</au><au>Fukushima, Yosuke</au><au>Sakata, Yasuaki</au><au>Katagiri, Takenobu</au><au>Rosen, Vicki</au><au>Yoda, Tetsuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2014-02-14</date><risdate>2014</risdate><volume>588</volume><issue>4</issue><spage>614</spage><epage>619</epage><pages>614-619</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>•ECR between M. musculus and H. sapiense, contains putative TCF/LEFs binding elements.•Wnt/β-catenin signaling regulates TLE3 expression in bone marrow stromal cells.•TLE3 suppresses Wnt/β-catenin signaling in bone marrow stromal cells. Transducing-like enhancer of split 3 (TLE3), one of the Groucho/TLE family members, targets Runx2 transcription and suppresses osteoblast differentiation in bone marrow stromal cells (BMSCs). Here, we identify Wnt responsive elements of the TLE3 promoter region through comparative genomic and functional analyses and show that expression of TLE3 is increased by Wnt signaling, which is important for osteoblast differentiation. We also demonstrated that TLE3 is able to suppress canonical Wnt signaling in BMSCs. Taken together, our data suggest that induction of TLE3 by Wnt signaling is part of a negative feedback loop active during osteoblast differentiation.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>24444608</pmid><doi>10.1016/j.febslet.2013.12.031</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects alkaline phosphatase
ALP
Animals
Base Sequence
beta Catenin - metabolism
Binding Sites
BMP
BMSC
bone marrow stromal cell
bone morphogenetic protein
C/EBP
CCAAT/enhancer-binding protein
Cell Differentiation
Cell Line
Co-repressor
Co-Repressor Proteins - genetics
Conserved Sequence
Gene Expression Regulation
Genomics
Groucho
Humans
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
Mice
Molecular Sequence Data
Osteoblastogenesis
Osteoblasts - cytology
Osteocalcin
Osteoporosis
PPARγ
proliferator-activated receptor γ
Response Elements - genetics
Signal Transduction
TLE
Transducing-like enhancer of split
Wnt
Wnt Proteins - metabolism
title Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling
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