Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications

Mutations in the cohesin complex are novel, genetic lesions in acute myeloid leukemia (AML) that are not well characterized. In this study, we analyzed the frequency, clinical, and prognostic implications of mutations in STAG1, STAG2, SMC1A, SMC3, and RAD21, all members of the cohesin complex, in a...

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Veröffentlicht in:	Blood 2014-02, Vol.123 (6), p.914-920
Hauptverfasser:	Thol, Felicitas, Bollin, Robin, Gehlhaar, Marten, Walter, Carolin, Dugas, Martin, Suchanek, Karl Josef, Kirchner, Aylin, Huang, Liu, Chaturvedi, Anuhar, Wichmann, Martin, Wiehlmann, Lutz, Shahswar, Rabia, Damm, Frederik, Göhring, Gudrun, Schlegelberger, Brigitte, Schlenk, Richard, Döhner, Konstanze, Döhner, Hartmut, Krauter, Jürgen, Ganser, Arnold, Heuser, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antigens, Nuclear - genetics Biomarkers, Tumor - genetics Case-Control Studies Cell Cycle Proteins - genetics Chondroitin Sulfate Proteoglycans - genetics Chromosomal Proteins, Non-Histone - genetics Cytogenetic Analysis DNA-Binding Proteins Female Follow-Up Studies Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - pathology Male Middle Aged Mutation Neoplasm Proteins - metabolism Neoplasm Staging Nuclear Proteins - genetics Phosphoproteins - genetics Polymerase Chain Reaction Prognosis Remission Induction Survival Rate Young Adult
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