SP600125 overcomes antimitotic drug-resistance in cancer cells by increasing apoptosis with independence of P-gp inhibition

The purpose of this study was to identify conditions that increase the sensitivity of resistant cancer cells to antimitotic drugs. Using MTS assays, microscopic observation, assessment of cleaved PARP, FACS analysis, and Hoechst staining, we found that the c-Jun N-terminal kinase (Jnk) inhibitor SP6...

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Veröffentlicht in:	European journal of pharmacology 2014-01, Vol.723, p.141-147
Hauptverfasser:	Kim, Ju-Hwa, Chae, Minji, Choi, Ae-Ran, Sik Kim, Hyung, Yoon, Sungpil
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracenes - pharmacology Antimitotic Agents - pharmacology Antimitotic drugs Apoptosis - drug effects ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Cancer Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Drug Resistance, Neoplasm - drug effects Humans JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors Resistance SP600125
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