New insights in the pathogenesis of atopic dermatitis

Atopic dermatitis (AD) is characterized by skin barrier defects and increased interleukin (IL)-4/IL-13 expression. Recent evidence also suggests the involvement of innate immunity including Toll-like receptors, IL-33, IL-25, and innate lymphoid cells in the pathogenesis of AD. This article reviews t...

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Veröffentlicht in:	Pediatric research 2014-01, Vol.75 (1-2), p.171-175
1. Verfasser:	Ong, Peck Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/721 692/420/2489/144 692/699/249/2510/1415 692/700/1720 Animals Anti-Inflammatory Agents - pharmacology Dermatitis, Atopic - diagnosis Dermatitis, Atopic - drug therapy Dermatitis, Atopic - genetics Dermatitis, Atopic - immunology Dermatitis, Atopic - microbiology Genetic Predisposition to Disease Humans Immunity, Innate - drug effects Intermediate Filament Proteins - genetics Keratinocytes - immunology Keratinocytes - pathology Medicine & Public Health Mutation Pediatric Surgery Pediatrics Phenotype review Risk Factors Skin - drug effects Skin - immunology Skin - microbiology Skin - pathology
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Zusammenfassung:	Atopic dermatitis (AD) is characterized by skin barrier defects and increased interleukin (IL)-4/IL-13 expression. Recent evidence also suggests the involvement of innate immunity including Toll-like receptors, IL-33, IL-25, and innate lymphoid cells in the pathogenesis of AD. This article reviews these innate immune components and how they may become an integral part of prognostic factors and therapeutic targets in the treatment of AD.
ISSN:	0031-3998 1530-0447
DOI:	10.1038/pr.2013.196