Enantioselective Functionalization of Indoles and Pyrroles via an in Situ-Formed Spiro Intermediate

Herein we report a highly enantioselective synthesis of polycyclic indoles and pyrroles with up to 99% ee by an iridium catalyst system consisting of a commercially available iridium precursor and a readily accessible ligand. Investigation of the reaction mechanism led to the discovery of an unprece...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society 2013-06, Vol.135 (22), p.8169-8172
Hauptverfasser:	Zhuo, Chun-Xiang, Wu, Qing-Feng, Zhao, Qiang, Xu, Qing-Long, You, Shu-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Indoles - chemical synthesis Indoles - chemistry Iridium - chemistry Molecular Structure Organometallic Compounds - chemistry Pyrroles - chemical synthesis Pyrroles - chemistry Spiro Compounds - chemical synthesis Spiro Compounds - chemistry Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!