Incidence of Malignancies in Patients with IgG4-related Disease
Objective It has been discussed whether IgG4-related disease (IgG4-RD), including autoimmune pancreatitis (AIP), is associated with malignancy; however, the issue has not been clarified. Methods We analyzed 113 patients with IgG4-RD in whom malignancy was not diagnosed at the time of IgG4-RD onset a...
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| Veröffentlicht in: | Internal Medicine 2014, Vol.53(3), pp.171-176 |
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| creator | Hirano, Kenji Tada, Minoru Sasahira, Naoki Isayama, Hiroyuki Mizuno, Suguru Takagi, Kaoru Watanabe, Takeo Saito, Tomotaka Kawahata, Shuhei Uchino, Rie Hamada, Tsuyoshi Miyabayashi, Koji Mohri, Dai Sasaki, Takashi Kogure, Hirofumi Yamamoto, Natsuyo Nakai, Yousuke Yoshida, Haruhiko Ito, Yukiko Akiyama, Dai Toda, Nobuo Arizumi, Toshihiko Yagioka, Hiroshi Takahara, Naminatsu Matsubara, Saburo Yashima, Yoko Koike, Kazuhiko |
| description | Objective It has been discussed whether IgG4-related disease (IgG4-RD), including autoimmune pancreatitis (AIP), is associated with malignancy; however, the issue has not been clarified. Methods We analyzed 113 patients with IgG4-RD in whom malignancy was not diagnosed at the time of IgG4-RD onset and the follow-up period was longer than six months. A total of 95 patients had AIP. The mean follow-up period was 73 months. The incidence of the observed malignancies was compared with the expected incidence in an age- and sex-matched general Japanese population based on the Vital Statistics of Japan. Results There were 15 malignancies (lung cancer in five patients, pancreatic cancer in two patients, gastric cancer in two patients, bile duct cancer in one patient, renal cancer in one patient, breast cancer in one patient, tongue cancer in one patient, malignant melanoma in one patient and acute myeloid leukemia in one patient) in 14 patients during the follow-up period. The calculated standardized incidence rate of the total malignancies was not significant, that is, 1.04 (95% CI 0.57-1.75). Conclusion The incidence of total malignancies in IgG4-RD patients is similar to that observed in the general population. At present, it is reasonable to conclude that IgG4-RD is not associated with an increased incidence of total malignancies. |
| doi_str_mv | 10.2169/internalmedicine.53.1342 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1499128040</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1499128040</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-5ee9c512935ab098fb29f3ee401e77142434fd369cb661524b8edd2033b6fa583</originalsourceid><addsrcrecordid>eNptkEtPwzAQhC0EoqXwF1COXFL8TOwTQjxKpfI4wNlynE3rKnWK7Qrx70nV0gPiMivtfjsjDUIZwWNKCnXtfILgTbuC2lnnYSzYmDBOj9CwHyovKRPHaIgVkTntZYDOYlxizGSp6CkaUM4VLSQbopupt64GbyHrmuzZtG7uTb-CmDmfvZnkwKeYfbm0yKbzCc8DtCZBnd27CCbCOTppTBvhYj9H6OPx4f3uKZ-9TqZ3t7PcClqkXAAoKwhVTJgKK9lUVDUMgGMCZUk45Yw3NSuUrYqCCMorCXVNMWNV0Rgh2Qhd7XzXofvcQEx65aKFtjUeuk3UhCtFqMQc96jcoTZ0MQZo9Dq4lQnfmmC9rU__rU8Lprf19a-X-5RN1R8Pj7999cDLDljGZOZwAExIzrbwrzPbyj7hANqFCRo8-wHQUoyR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1499128040</pqid></control><display><type>article</type><title>Incidence of Malignancies in Patients with IgG4-related Disease</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><creator>Hirano, Kenji ; Tada, Minoru ; Sasahira, Naoki ; Isayama, Hiroyuki ; Mizuno, Suguru ; Takagi, Kaoru ; Watanabe, Takeo ; Saito, Tomotaka ; Kawahata, Shuhei ; Uchino, Rie ; Hamada, Tsuyoshi ; Miyabayashi, Koji ; Mohri, Dai ; Sasaki, Takashi ; Kogure, Hirofumi ; Yamamoto, Natsuyo ; Nakai, Yousuke ; Yoshida, Haruhiko ; Ito, Yukiko ; Akiyama, Dai ; Toda, Nobuo ; Arizumi, Toshihiko ; Yagioka, Hiroshi ; Takahara, Naminatsu ; Matsubara, Saburo ; Yashima, Yoko ; Koike, Kazuhiko</creator><creatorcontrib>Hirano, Kenji ; Tada, Minoru ; Sasahira, Naoki ; Isayama, Hiroyuki ; Mizuno, Suguru ; Takagi, Kaoru ; Watanabe, Takeo ; Saito, Tomotaka ; Kawahata, Shuhei ; Uchino, Rie ; Hamada, Tsuyoshi ; Miyabayashi, Koji ; Mohri, Dai ; Sasaki, Takashi ; Kogure, Hirofumi ; Yamamoto, Natsuyo ; Nakai, Yousuke ; Yoshida, Haruhiko ; Ito, Yukiko ; Akiyama, Dai ; Toda, Nobuo ; Arizumi, Toshihiko ; Yagioka, Hiroshi ; Takahara, Naminatsu ; Matsubara, Saburo ; Yashima, Yoko ; Koike, Kazuhiko</creatorcontrib><description>Objective It has been discussed whether IgG4-related disease (IgG4-RD), including autoimmune pancreatitis (AIP), is associated with malignancy; however, the issue has not been clarified. Methods We analyzed 113 patients with IgG4-RD in whom malignancy was not diagnosed at the time of IgG4-RD onset and the follow-up period was longer than six months. A total of 95 patients had AIP. The mean follow-up period was 73 months. The incidence of the observed malignancies was compared with the expected incidence in an age- and sex-matched general Japanese population based on the Vital Statistics of Japan. Results There were 15 malignancies (lung cancer in five patients, pancreatic cancer in two patients, gastric cancer in two patients, bile duct cancer in one patient, renal cancer in one patient, breast cancer in one patient, tongue cancer in one patient, malignant melanoma in one patient and acute myeloid leukemia in one patient) in 14 patients during the follow-up period. The calculated standardized incidence rate of the total malignancies was not significant, that is, 1.04 (95% CI 0.57-1.75). Conclusion The incidence of total malignancies in IgG4-RD patients is similar to that observed in the general population. At present, it is reasonable to conclude that IgG4-RD is not associated with an increased incidence of total malignancies.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.53.1342</identifier><identifier>PMID: 24492683</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Aged ; Autoimmune Diseases - blood ; Autoimmune Diseases - diagnosis ; Autoimmune Diseases - epidemiology ; autoimmune pancreatitis ; diabetes mellitus ; Female ; Follow-Up Studies ; Humans ; IgG4-related disease ; Immunoglobulin G - blood ; Incidence ; Male ; malignancy ; Middle Aged ; Neoplasms - blood ; Neoplasms - diagnosis ; Neoplasms - epidemiology ; Prospective Studies</subject><ispartof>Internal Medicine, 2014, Vol.53(3), pp.171-176</ispartof><rights>2014 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-5ee9c512935ab098fb29f3ee401e77142434fd369cb661524b8edd2033b6fa583</citedby><cites>FETCH-LOGICAL-c526t-5ee9c512935ab098fb29f3ee401e77142434fd369cb661524b8edd2033b6fa583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24492683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirano, Kenji</creatorcontrib><creatorcontrib>Tada, Minoru</creatorcontrib><creatorcontrib>Sasahira, Naoki</creatorcontrib><creatorcontrib>Isayama, Hiroyuki</creatorcontrib><creatorcontrib>Mizuno, Suguru</creatorcontrib><creatorcontrib>Takagi, Kaoru</creatorcontrib><creatorcontrib>Watanabe, Takeo</creatorcontrib><creatorcontrib>Saito, Tomotaka</creatorcontrib><creatorcontrib>Kawahata, Shuhei</creatorcontrib><creatorcontrib>Uchino, Rie</creatorcontrib><creatorcontrib>Hamada, Tsuyoshi</creatorcontrib><creatorcontrib>Miyabayashi, Koji</creatorcontrib><creatorcontrib>Mohri, Dai</creatorcontrib><creatorcontrib>Sasaki, Takashi</creatorcontrib><creatorcontrib>Kogure, Hirofumi</creatorcontrib><creatorcontrib>Yamamoto, Natsuyo</creatorcontrib><creatorcontrib>Nakai, Yousuke</creatorcontrib><creatorcontrib>Yoshida, Haruhiko</creatorcontrib><creatorcontrib>Ito, Yukiko</creatorcontrib><creatorcontrib>Akiyama, Dai</creatorcontrib><creatorcontrib>Toda, Nobuo</creatorcontrib><creatorcontrib>Arizumi, Toshihiko</creatorcontrib><creatorcontrib>Yagioka, Hiroshi</creatorcontrib><creatorcontrib>Takahara, Naminatsu</creatorcontrib><creatorcontrib>Matsubara, Saburo</creatorcontrib><creatorcontrib>Yashima, Yoko</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><title>Incidence of Malignancies in Patients with IgG4-related Disease</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Objective It has been discussed whether IgG4-related disease (IgG4-RD), including autoimmune pancreatitis (AIP), is associated with malignancy; however, the issue has not been clarified. Methods We analyzed 113 patients with IgG4-RD in whom malignancy was not diagnosed at the time of IgG4-RD onset and the follow-up period was longer than six months. A total of 95 patients had AIP. The mean follow-up period was 73 months. The incidence of the observed malignancies was compared with the expected incidence in an age- and sex-matched general Japanese population based on the Vital Statistics of Japan. Results There were 15 malignancies (lung cancer in five patients, pancreatic cancer in two patients, gastric cancer in two patients, bile duct cancer in one patient, renal cancer in one patient, breast cancer in one patient, tongue cancer in one patient, malignant melanoma in one patient and acute myeloid leukemia in one patient) in 14 patients during the follow-up period. The calculated standardized incidence rate of the total malignancies was not significant, that is, 1.04 (95% CI 0.57-1.75). Conclusion The incidence of total malignancies in IgG4-RD patients is similar to that observed in the general population. At present, it is reasonable to conclude that IgG4-RD is not associated with an increased incidence of total malignancies.</description><subject>Aged</subject><subject>Autoimmune Diseases - blood</subject><subject>Autoimmune Diseases - diagnosis</subject><subject>Autoimmune Diseases - epidemiology</subject><subject>autoimmune pancreatitis</subject><subject>diabetes mellitus</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>IgG4-related disease</subject><subject>Immunoglobulin G - blood</subject><subject>Incidence</subject><subject>Male</subject><subject>malignancy</subject><subject>Middle Aged</subject><subject>Neoplasms - blood</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - epidemiology</subject><subject>Prospective Studies</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtPwzAQhC0EoqXwF1COXFL8TOwTQjxKpfI4wNlynE3rKnWK7Qrx70nV0gPiMivtfjsjDUIZwWNKCnXtfILgTbuC2lnnYSzYmDBOj9CwHyovKRPHaIgVkTntZYDOYlxizGSp6CkaUM4VLSQbopupt64GbyHrmuzZtG7uTb-CmDmfvZnkwKeYfbm0yKbzCc8DtCZBnd27CCbCOTppTBvhYj9H6OPx4f3uKZ-9TqZ3t7PcClqkXAAoKwhVTJgKK9lUVDUMgGMCZUk45Yw3NSuUrYqCCMorCXVNMWNV0Rgh2Qhd7XzXofvcQEx65aKFtjUeuk3UhCtFqMQc96jcoTZ0MQZo9Dq4lQnfmmC9rU__rU8Lprf19a-X-5RN1R8Pj7999cDLDljGZOZwAExIzrbwrzPbyj7hANqFCRo8-wHQUoyR</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Hirano, Kenji</creator><creator>Tada, Minoru</creator><creator>Sasahira, Naoki</creator><creator>Isayama, Hiroyuki</creator><creator>Mizuno, Suguru</creator><creator>Takagi, Kaoru</creator><creator>Watanabe, Takeo</creator><creator>Saito, Tomotaka</creator><creator>Kawahata, Shuhei</creator><creator>Uchino, Rie</creator><creator>Hamada, Tsuyoshi</creator><creator>Miyabayashi, Koji</creator><creator>Mohri, Dai</creator><creator>Sasaki, Takashi</creator><creator>Kogure, Hirofumi</creator><creator>Yamamoto, Natsuyo</creator><creator>Nakai, Yousuke</creator><creator>Yoshida, Haruhiko</creator><creator>Ito, Yukiko</creator><creator>Akiyama, Dai</creator><creator>Toda, Nobuo</creator><creator>Arizumi, Toshihiko</creator><creator>Yagioka, Hiroshi</creator><creator>Takahara, Naminatsu</creator><creator>Matsubara, Saburo</creator><creator>Yashima, Yoko</creator><creator>Koike, Kazuhiko</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140101</creationdate><title>Incidence of Malignancies in Patients with IgG4-related Disease</title><author>Hirano, Kenji ; Tada, Minoru ; Sasahira, Naoki ; Isayama, Hiroyuki ; Mizuno, Suguru ; Takagi, Kaoru ; Watanabe, Takeo ; Saito, Tomotaka ; Kawahata, Shuhei ; Uchino, Rie ; Hamada, Tsuyoshi ; Miyabayashi, Koji ; Mohri, Dai ; Sasaki, Takashi ; Kogure, Hirofumi ; Yamamoto, Natsuyo ; Nakai, Yousuke ; Yoshida, Haruhiko ; Ito, Yukiko ; Akiyama, Dai ; Toda, Nobuo ; Arizumi, Toshihiko ; Yagioka, Hiroshi ; Takahara, Naminatsu ; Matsubara, Saburo ; Yashima, Yoko ; Koike, Kazuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-5ee9c512935ab098fb29f3ee401e77142434fd369cb661524b8edd2033b6fa583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Autoimmune Diseases - blood</topic><topic>Autoimmune Diseases - diagnosis</topic><topic>Autoimmune Diseases - epidemiology</topic><topic>autoimmune pancreatitis</topic><topic>diabetes mellitus</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>IgG4-related disease</topic><topic>Immunoglobulin G - blood</topic><topic>Incidence</topic><topic>Male</topic><topic>malignancy</topic><topic>Middle Aged</topic><topic>Neoplasms - blood</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - epidemiology</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirano, Kenji</creatorcontrib><creatorcontrib>Tada, Minoru</creatorcontrib><creatorcontrib>Sasahira, Naoki</creatorcontrib><creatorcontrib>Isayama, Hiroyuki</creatorcontrib><creatorcontrib>Mizuno, Suguru</creatorcontrib><creatorcontrib>Takagi, Kaoru</creatorcontrib><creatorcontrib>Watanabe, Takeo</creatorcontrib><creatorcontrib>Saito, Tomotaka</creatorcontrib><creatorcontrib>Kawahata, Shuhei</creatorcontrib><creatorcontrib>Uchino, Rie</creatorcontrib><creatorcontrib>Hamada, Tsuyoshi</creatorcontrib><creatorcontrib>Miyabayashi, Koji</creatorcontrib><creatorcontrib>Mohri, Dai</creatorcontrib><creatorcontrib>Sasaki, Takashi</creatorcontrib><creatorcontrib>Kogure, Hirofumi</creatorcontrib><creatorcontrib>Yamamoto, Natsuyo</creatorcontrib><creatorcontrib>Nakai, Yousuke</creatorcontrib><creatorcontrib>Yoshida, Haruhiko</creatorcontrib><creatorcontrib>Ito, Yukiko</creatorcontrib><creatorcontrib>Akiyama, Dai</creatorcontrib><creatorcontrib>Toda, Nobuo</creatorcontrib><creatorcontrib>Arizumi, Toshihiko</creatorcontrib><creatorcontrib>Yagioka, Hiroshi</creatorcontrib><creatorcontrib>Takahara, Naminatsu</creatorcontrib><creatorcontrib>Matsubara, Saburo</creatorcontrib><creatorcontrib>Yashima, Yoko</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirano, Kenji</au><au>Tada, Minoru</au><au>Sasahira, Naoki</au><au>Isayama, Hiroyuki</au><au>Mizuno, Suguru</au><au>Takagi, Kaoru</au><au>Watanabe, Takeo</au><au>Saito, Tomotaka</au><au>Kawahata, Shuhei</au><au>Uchino, Rie</au><au>Hamada, Tsuyoshi</au><au>Miyabayashi, Koji</au><au>Mohri, Dai</au><au>Sasaki, Takashi</au><au>Kogure, Hirofumi</au><au>Yamamoto, Natsuyo</au><au>Nakai, Yousuke</au><au>Yoshida, Haruhiko</au><au>Ito, Yukiko</au><au>Akiyama, Dai</au><au>Toda, Nobuo</au><au>Arizumi, Toshihiko</au><au>Yagioka, Hiroshi</au><au>Takahara, Naminatsu</au><au>Matsubara, Saburo</au><au>Yashima, Yoko</au><au>Koike, Kazuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of Malignancies in Patients with IgG4-related Disease</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>53</volume><issue>3</issue><spage>171</spage><epage>176</epage><pages>171-176</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Objective It has been discussed whether IgG4-related disease (IgG4-RD), including autoimmune pancreatitis (AIP), is associated with malignancy; however, the issue has not been clarified. Methods We analyzed 113 patients with IgG4-RD in whom malignancy was not diagnosed at the time of IgG4-RD onset and the follow-up period was longer than six months. A total of 95 patients had AIP. The mean follow-up period was 73 months. The incidence of the observed malignancies was compared with the expected incidence in an age- and sex-matched general Japanese population based on the Vital Statistics of Japan. Results There were 15 malignancies (lung cancer in five patients, pancreatic cancer in two patients, gastric cancer in two patients, bile duct cancer in one patient, renal cancer in one patient, breast cancer in one patient, tongue cancer in one patient, malignant melanoma in one patient and acute myeloid leukemia in one patient) in 14 patients during the follow-up period. The calculated standardized incidence rate of the total malignancies was not significant, that is, 1.04 (95% CI 0.57-1.75). Conclusion The incidence of total malignancies in IgG4-RD patients is similar to that observed in the general population. At present, it is reasonable to conclude that IgG4-RD is not associated with an increased incidence of total malignancies.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>24492683</pmid><doi>10.2169/internalmedicine.53.1342</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Autoimmune Diseases - blood Autoimmune Diseases - diagnosis Autoimmune Diseases - epidemiology autoimmune pancreatitis diabetes mellitus Female Follow-Up Studies Humans IgG4-related disease Immunoglobulin G - blood Incidence Male malignancy Middle Aged Neoplasms - blood Neoplasms - diagnosis Neoplasms - epidemiology Prospective Studies |
| title | Incidence of Malignancies in Patients with IgG4-related Disease |
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