Inhibition of porcine endogenous retrovirus in PK15 cell line by efficient multitargeting RNA interference

Summary To effectively suppress porcine endogenous retroviruses (PERV)s, RNAi technique was utilized. RNAi is the up‐to‐date skill for gene knockdown which simultaneously multitargets both gag and pol genes critical for replication of PERVs. Previously, two of the most effective siRNAs (gag2, pol2)...

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Veröffentlicht in:	Transplant international 2014-01, Vol.27 (1), p.96-105
Hauptverfasser:	Chung, Hee‐Chun, Nguyen, Van‐Giap, Moon, Hyoung‐Joon, Kim, Hye‐Kwon, Park, Seong‐Jun, Lee, Jee‐Hoon, Choi, Min‐Gyung, Kim, A‐Reum, Park, Bong‐Kyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Coculture Techniques Endogenous Retroviruses - physiology Gene Knockdown Techniques Genes, gag - drug effects Genes, pol - drug effects HEK293 Cells Humans inhibition multitargeting PK15 cells Porcine endogenous retrovirus RNA Interference Swine
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