Estimation of ochratoxin A in the human blood of Romanian population
Ochratoxin A (OTA) is a toxic secondary metabolite of fungi belonging to the Aspergillus and Penicillium genera, its presence in human blood being the primary indicator of exposure. In the present study we determined OTA in 38 blood samples collected from healthy Romanian subjects of both genders. T...
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| Veröffentlicht in: | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 2013-10, Vol.117 (4), p.1009-1013 |
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| container_title | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi |
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| creator | Zlăvog, Anca Vartolomei Cuciureanu, Magdalena Schiriac, Elena Popa, Ionela Diaconu, Camelia Cuciureanu, Rodica |
| description | Ochratoxin A (OTA) is a toxic secondary metabolite of fungi belonging to the Aspergillus and Penicillium genera, its presence in human blood being the primary indicator of exposure.
In the present study we determined OTA in 38 blood samples collected from healthy Romanian subjects of both genders.
The OTA was determined through the direct, competitive, solid-phase immunoenzymatic method; the minimum quantification limit for determining OTA in serum samples was 0.0289 ng/mL.
The positive sample percentage was 100%. OTA concentrations varied between < 0.04 ng/mL and 1 ng/mL. There were no significant differences between OTA concentrations in men versus women (0.24 +/- 0.20 ng/mL versus 0.17 +/- 0.15 ng/mL, p = 0.3527).
The analyzed blood samples exhibit a very high degree of exposure to OTA, but in only approximately 10% of the subjects exceeded 0.5 ng/mL, considered the threshold for OTA-induced renal pathology. |
| format | Article |
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In the present study we determined OTA in 38 blood samples collected from healthy Romanian subjects of both genders.
The OTA was determined through the direct, competitive, solid-phase immunoenzymatic method; the minimum quantification limit for determining OTA in serum samples was 0.0289 ng/mL.
The positive sample percentage was 100%. OTA concentrations varied between < 0.04 ng/mL and 1 ng/mL. There were no significant differences between OTA concentrations in men versus women (0.24 +/- 0.20 ng/mL versus 0.17 +/- 0.15 ng/mL, p = 0.3527).
The analyzed blood samples exhibit a very high degree of exposure to OTA, but in only approximately 10% of the subjects exceeded 0.5 ng/mL, considered the threshold for OTA-induced renal pathology.</description><identifier>ISSN: 0048-7848</identifier><identifier>PMID: 24502083</identifier><language>eng</language><publisher>Romania</publisher><subject>Adult ; Body Mass Index ; Carcinogens - metabolism ; Epidemiological Monitoring ; Female ; Glomerulonephritis - blood ; Glomerulonephritis - diagnosis ; Glomerulonephritis - epidemiology ; Humans ; Male ; Middle Aged ; Ochratoxins - blood ; Romania - epidemiology ; Rural Population - statistics & numerical data ; Urban Population - statistics & numerical data</subject><ispartof>Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 2013-10, Vol.117 (4), p.1009-1013</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24502083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zlăvog, Anca Vartolomei</creatorcontrib><creatorcontrib>Cuciureanu, Magdalena</creatorcontrib><creatorcontrib>Schiriac, Elena</creatorcontrib><creatorcontrib>Popa, Ionela</creatorcontrib><creatorcontrib>Diaconu, Camelia</creatorcontrib><creatorcontrib>Cuciureanu, Rodica</creatorcontrib><title>Estimation of ochratoxin A in the human blood of Romanian population</title><title>Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi</title><addtitle>Rev Med Chir Soc Med Nat Iasi</addtitle><description>Ochratoxin A (OTA) is a toxic secondary metabolite of fungi belonging to the Aspergillus and Penicillium genera, its presence in human blood being the primary indicator of exposure.
In the present study we determined OTA in 38 blood samples collected from healthy Romanian subjects of both genders.
The OTA was determined through the direct, competitive, solid-phase immunoenzymatic method; the minimum quantification limit for determining OTA in serum samples was 0.0289 ng/mL.
The positive sample percentage was 100%. OTA concentrations varied between < 0.04 ng/mL and 1 ng/mL. There were no significant differences between OTA concentrations in men versus women (0.24 +/- 0.20 ng/mL versus 0.17 +/- 0.15 ng/mL, p = 0.3527).
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In the present study we determined OTA in 38 blood samples collected from healthy Romanian subjects of both genders.
The OTA was determined through the direct, competitive, solid-phase immunoenzymatic method; the minimum quantification limit for determining OTA in serum samples was 0.0289 ng/mL.
The positive sample percentage was 100%. OTA concentrations varied between < 0.04 ng/mL and 1 ng/mL. There were no significant differences between OTA concentrations in men versus women (0.24 +/- 0.20 ng/mL versus 0.17 +/- 0.15 ng/mL, p = 0.3527).
The analyzed blood samples exhibit a very high degree of exposure to OTA, but in only approximately 10% of the subjects exceeded 0.5 ng/mL, considered the threshold for OTA-induced renal pathology.</abstract><cop>Romania</cop><pmid>24502083</pmid><tpages>5</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Body Mass Index Carcinogens - metabolism Epidemiological Monitoring Female Glomerulonephritis - blood Glomerulonephritis - diagnosis Glomerulonephritis - epidemiology Humans Male Middle Aged Ochratoxins - blood Romania - epidemiology Rural Population - statistics & numerical data Urban Population - statistics & numerical data |
| title | Estimation of ochratoxin A in the human blood of Romanian population |
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