Directing Group Enhanced Carbonylative Ring Expansions of Amino-Substituted Cyclopropanes: Rhodium-Catalyzed Multicomponent Synthesis of N‑Heterobicyclic Enones

Aminocyclopropanes equipped with suitable N-directing groups undergo efficient and regioselective Rh-catalyzed carbonylative C–C bond activation. Trapping of the resultant metallacycles with tethered alkynes provides an atom-economic entry to diverse N-heterobicyclic enones. These studies provide a...

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Veröffentlicht in:	Journal of the American Chemical Society 2013-04, Vol.135 (13), p.4992-4995
Hauptverfasser:	Shaw, Megan H, Melikhova, Ekaterina Y, Kloer, Daniel P, Whittingham, William G, Bower, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry Bridged Bicyclo Compounds, Heterocyclic - chemistry Catalysis Cyclopropanes - chemistry Ketones - chemistry Molecular Structure Rhodium - chemistry
Online-Zugang:	Volltext
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