Asterosaponins from the Starfish Astropecten monacanthus Suppress Growth and Induce Apoptosis in HL-60, PC-3, and SNU-C5 Human Cancer Cell Lines
Using various chromatographic experiments, six asterosaponins (1−6) were isolated from the MeOH extract of the Vietnamese starfish Astropecten monacanthus. The cytotoxic activities of the MeOH extract and six asterosaponins were evaluated on three human cancer cell lines, HL-60 (promyelocytic leukem...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2014/02/01, Vol.37(2), pp.315-321 |
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| creator | Thao, Nguyen Phuong Luyen, Bui Thi Thuy Kim, Eun-Ji Kang, Hee-Kyoung Kim, Sohyun Cuong, Nguyen Xuan Nam, Nguyen Hoai Kiem, Phan Van Minh, Chau Van Kim, Young Ho |
| description | Using various chromatographic experiments, six asterosaponins (1−6) were isolated from the MeOH extract of the Vietnamese starfish Astropecten monacanthus. The cytotoxic activities of the MeOH extract and six asterosaponins were evaluated on three human cancer cell lines, HL-60 (promyelocytic leukemia), PC-3 (prostate cancer), and SNU-C5 (colorectal cancer). Relative to the effects of the postitive control mitoxantrone, the MeOH extract (with IC50 values ranging from 0.84±0.03 to 3.96±0.14 µg/mL) and astrosterioside D (5) (with IC50 values ranging from 4.31±0.07 to 5.21±0.15 µ M ) exhibited potent cytotoxic effects against all three tested human cancer cell lines. In addition, the MeOH extract and astrosterioside D (5) have an effect on leading to apoptosis. Interestingly, the apoptosis of induction was accompanied by down-regulation of phosphatidyl inositol 3-kinase (PI3K)/AKT signaling and extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein kinase (MAPK) signaling, and decrease of c-myc expression. Further studies are required to establish use of the asterosaponins from A. monacanthus as remedial and/or nutraceutical purposes. |
| doi_str_mv | 10.1248/bpb.b13-00705 |
| format | Article |
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The cytotoxic activities of the MeOH extract and six asterosaponins were evaluated on three human cancer cell lines, HL-60 (promyelocytic leukemia), PC-3 (prostate cancer), and SNU-C5 (colorectal cancer). Relative to the effects of the postitive control mitoxantrone, the MeOH extract (with IC50 values ranging from 0.84±0.03 to 3.96±0.14 µg/mL) and astrosterioside D (5) (with IC50 values ranging from 4.31±0.07 to 5.21±0.15 µ M ) exhibited potent cytotoxic effects against all three tested human cancer cell lines. In addition, the MeOH extract and astrosterioside D (5) have an effect on leading to apoptosis. Interestingly, the apoptosis of induction was accompanied by down-regulation of phosphatidyl inositol 3-kinase (PI3K)/AKT signaling and extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein kinase (MAPK) signaling, and decrease of c-myc expression. Further studies are required to establish use of the asterosaponins from A. monacanthus as remedial and/or nutraceutical purposes.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b13-00705</identifier><identifier>PMID: 24492728</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; apoptosis ; Apoptosis - drug effects ; asterosaponin ; Astropecten monacanthus ; Biological Products - pharmacology ; Biological Products - therapeutic use ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - metabolism ; cytotoxic ; Down-Regulation ; Extracellular Signal-Regulated MAP Kinases - metabolism ; HL-60 Cells ; Humans ; Leukemia, Promyelocytic, Acute - drug therapy ; Leukemia, Promyelocytic, Acute - metabolism ; Male ; Mitogen-Activated Protein Kinase 1 - metabolism ; Mitogen-Activated Protein Kinase 3 - metabolism ; Mitogen-Activated Protein Kinases - metabolism ; Phosphatidylinositol 3-Kinase - metabolism ; Phosphatidylinositol 3-Kinases - metabolism ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - metabolism ; Proto-Oncogene Proteins c-akt - metabolism ; Saponins - pharmacology ; Saponins - therapeutic use ; Signal Transduction ; starfish ; Starfish - chemistry</subject><ispartof>Biological and Pharmaceutical Bulletin, 2014/02/01, Vol.37(2), pp.315-321</ispartof><rights>2014 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5935-bf91b835832183bae27c4c245bcc1fa405b43cacdbd79e7c8306b0ea4a40407f3</citedby><cites>FETCH-LOGICAL-c5935-bf91b835832183bae27c4c245bcc1fa405b43cacdbd79e7c8306b0ea4a40407f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24492728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thao, Nguyen Phuong</creatorcontrib><creatorcontrib>Luyen, Bui Thi Thuy</creatorcontrib><creatorcontrib>Kim, Eun-Ji</creatorcontrib><creatorcontrib>Kang, Hee-Kyoung</creatorcontrib><creatorcontrib>Kim, Sohyun</creatorcontrib><creatorcontrib>Cuong, Nguyen Xuan</creatorcontrib><creatorcontrib>Nam, Nguyen Hoai</creatorcontrib><creatorcontrib>Kiem, Phan Van</creatorcontrib><creatorcontrib>Minh, Chau Van</creatorcontrib><creatorcontrib>Kim, Young Ho</creatorcontrib><creatorcontrib>School of Medicine</creatorcontrib><creatorcontrib>Institute of Medical Sciences</creatorcontrib><creatorcontrib>Department of Pharmacology</creatorcontrib><creatorcontrib>Vietnam Academy of Science and Technology</creatorcontrib><creatorcontrib>and Institute of Medical Science</creatorcontrib><creatorcontrib>Institute of Marine Biochemistry</creatorcontrib><creatorcontrib>Jeju National University</creatorcontrib><creatorcontrib>College of Pharmacy</creatorcontrib><creatorcontrib>Chungnam National University</creatorcontrib><creatorcontrib>Brain Korea Program</creatorcontrib><title>Asterosaponins from the Starfish Astropecten monacanthus Suppress Growth and Induce Apoptosis in HL-60, PC-3, and SNU-C5 Human Cancer Cell Lines</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Using various chromatographic experiments, six asterosaponins (1−6) were isolated from the MeOH extract of the Vietnamese starfish Astropecten monacanthus. The cytotoxic activities of the MeOH extract and six asterosaponins were evaluated on three human cancer cell lines, HL-60 (promyelocytic leukemia), PC-3 (prostate cancer), and SNU-C5 (colorectal cancer). Relative to the effects of the postitive control mitoxantrone, the MeOH extract (with IC50 values ranging from 0.84±0.03 to 3.96±0.14 µg/mL) and astrosterioside D (5) (with IC50 values ranging from 4.31±0.07 to 5.21±0.15 µ M ) exhibited potent cytotoxic effects against all three tested human cancer cell lines. In addition, the MeOH extract and astrosterioside D (5) have an effect on leading to apoptosis. Interestingly, the apoptosis of induction was accompanied by down-regulation of phosphatidyl inositol 3-kinase (PI3K)/AKT signaling and extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein kinase (MAPK) signaling, and decrease of c-myc expression. Further studies are required to establish use of the asterosaponins from A. monacanthus as remedial and/or nutraceutical purposes.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>asterosaponin</subject><subject>Astropecten monacanthus</subject><subject>Biological Products - pharmacology</subject><subject>Biological Products - therapeutic use</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>cytotoxic</subject><subject>Down-Regulation</subject><subject>Extracellular Signal-Regulated MAP Kinases - metabolism</subject><subject>HL-60 Cells</subject><subject>Humans</subject><subject>Leukemia, Promyelocytic, Acute - drug therapy</subject><subject>Leukemia, Promyelocytic, Acute - metabolism</subject><subject>Male</subject><subject>Mitogen-Activated Protein Kinase 1 - metabolism</subject><subject>Mitogen-Activated Protein Kinase 3 - metabolism</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Phosphatidylinositol 3-Kinase - metabolism</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Saponins - pharmacology</subject><subject>Saponins - therapeutic use</subject><subject>Signal Transduction</subject><subject>starfish</subject><subject>Starfish - chemistry</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc2O0zAUhS0EYkphyRZZYsNiPPi3TpZVBO1IFSCVWVu245BUiR3sRCPegkfGaYcisbl3cT-de3QOAG8JviOUFx_NaO4MYQhjicUzsCKMSyQoEc_BCpekQBsiihvwKqUTXhjKXoIbynlJJS1W4Pc2TS6GpMfgO59gE8MAp9bB46Rj06UWZiCG0dnJeTgEr632UzsneJzHMbqU4C6Gx6mF2tfw3tezdXA7hnEKqUuw83B_QBt8C79ViN2eoeOXB1QJuJ8H7WGlvXURVq7v4aHzLr0GLxrdJ_fmaa_Bw-dP36s9Onzd3VfbA7KiZAKZpiSmYKJglBTMaEel5ZZyYawljeZYGM6strWpZemkLRjeGOw0zyeOZcPW4MNFd4zh5-zSpIYu2WxDexfmpAgvyxwwyepr8P4_9BTm6LO7heIbLkrBM4UulM1xpugaNcZu0PGXIlgtValclcpVqXNVmX_3pDqbwdVX-m83GdhdgHztrO6D73NA_37bJE0X-qAoJjyLslyuwpQozIjIgxJKSSnl8qq6KJ3SpH-46ysdp8727myMSUWXcTV4vdpWR-U8-wP4orxY</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Thao, Nguyen Phuong</creator><creator>Luyen, Bui Thi Thuy</creator><creator>Kim, Eun-Ji</creator><creator>Kang, Hee-Kyoung</creator><creator>Kim, Sohyun</creator><creator>Cuong, Nguyen Xuan</creator><creator>Nam, Nguyen Hoai</creator><creator>Kiem, Phan Van</creator><creator>Minh, Chau Van</creator><creator>Kim, Young Ho</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Asterosaponins from the Starfish Astropecten monacanthus Suppress Growth and Induce Apoptosis in HL-60, PC-3, and SNU-C5 Human Cancer Cell Lines</title><author>Thao, Nguyen Phuong ; Luyen, Bui Thi Thuy ; Kim, Eun-Ji ; Kang, Hee-Kyoung ; Kim, Sohyun ; Cuong, Nguyen Xuan ; Nam, Nguyen Hoai ; Kiem, Phan Van ; Minh, Chau Van ; Kim, Young Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5935-bf91b835832183bae27c4c245bcc1fa405b43cacdbd79e7c8306b0ea4a40407f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>asterosaponin</topic><topic>Astropecten monacanthus</topic><topic>Biological Products - pharmacology</topic><topic>Biological Products - therapeutic use</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>cytotoxic</topic><topic>Down-Regulation</topic><topic>Extracellular Signal-Regulated MAP Kinases - metabolism</topic><topic>HL-60 Cells</topic><topic>Humans</topic><topic>Leukemia, Promyelocytic, Acute - drug therapy</topic><topic>Leukemia, Promyelocytic, Acute - metabolism</topic><topic>Male</topic><topic>Mitogen-Activated Protein Kinase 1 - metabolism</topic><topic>Mitogen-Activated Protein Kinase 3 - metabolism</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Phosphatidylinositol 3-Kinase - 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Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thao, Nguyen Phuong</au><au>Luyen, Bui Thi Thuy</au><au>Kim, Eun-Ji</au><au>Kang, Hee-Kyoung</au><au>Kim, Sohyun</au><au>Cuong, Nguyen Xuan</au><au>Nam, Nguyen Hoai</au><au>Kiem, Phan Van</au><au>Minh, Chau Van</au><au>Kim, Young Ho</au><aucorp>School of Medicine</aucorp><aucorp>Institute of Medical Sciences</aucorp><aucorp>Department of Pharmacology</aucorp><aucorp>Vietnam Academy of Science and Technology</aucorp><aucorp>and Institute of Medical Science</aucorp><aucorp>Institute of Marine Biochemistry</aucorp><aucorp>Jeju National University</aucorp><aucorp>College of Pharmacy</aucorp><aucorp>Chungnam National University</aucorp><aucorp>Brain Korea Program</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Asterosaponins from the Starfish Astropecten monacanthus Suppress Growth and Induce Apoptosis in HL-60, PC-3, and SNU-C5 Human Cancer Cell Lines</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2014</date><risdate>2014</risdate><volume>37</volume><issue>2</issue><spage>315</spage><epage>321</epage><pages>315-321</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Using various chromatographic experiments, six asterosaponins (1−6) were isolated from the MeOH extract of the Vietnamese starfish Astropecten monacanthus. The cytotoxic activities of the MeOH extract and six asterosaponins were evaluated on three human cancer cell lines, HL-60 (promyelocytic leukemia), PC-3 (prostate cancer), and SNU-C5 (colorectal cancer). Relative to the effects of the postitive control mitoxantrone, the MeOH extract (with IC50 values ranging from 0.84±0.03 to 3.96±0.14 µg/mL) and astrosterioside D (5) (with IC50 values ranging from 4.31±0.07 to 5.21±0.15 µ M ) exhibited potent cytotoxic effects against all three tested human cancer cell lines. In addition, the MeOH extract and astrosterioside D (5) have an effect on leading to apoptosis. Interestingly, the apoptosis of induction was accompanied by down-regulation of phosphatidyl inositol 3-kinase (PI3K)/AKT signaling and extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein kinase (MAPK) signaling, and decrease of c-myc expression. Further studies are required to establish use of the asterosaponins from A. monacanthus as remedial and/or nutraceutical purposes.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>24492728</pmid><doi>10.1248/bpb.b13-00705</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biological and Pharmaceutical Bulletin, 2014/02/01, Vol.37(2), pp.315-321 |
| issn | 0918-6158 1347-5215 |
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| subjects | Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use apoptosis Apoptosis - drug effects asterosaponin Astropecten monacanthus Biological Products - pharmacology Biological Products - therapeutic use Cell Line, Tumor Cell Proliferation - drug effects Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism cytotoxic Down-Regulation Extracellular Signal-Regulated MAP Kinases - metabolism HL-60 Cells Humans Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - metabolism Male Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Mitogen-Activated Protein Kinases - metabolism Phosphatidylinositol 3-Kinase - metabolism Phosphatidylinositol 3-Kinases - metabolism Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Proto-Oncogene Proteins c-akt - metabolism Saponins - pharmacology Saponins - therapeutic use Signal Transduction starfish Starfish - chemistry |
| title | Asterosaponins from the Starfish Astropecten monacanthus Suppress Growth and Induce Apoptosis in HL-60, PC-3, and SNU-C5 Human Cancer Cell Lines |
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