Steroidomimetic Aminomethyl Spiroacetals as Novel Inhibitors of the Enzyme Δ8,7-Sterol Isomerase in Cholesterol Biosynthesis

Grundmann's ketone is converted to a spiroacetal containing a 5‐hydroxymethyl‐5‐nitro‐1,3‐dioxane moiety whose hydroxymethyl group can be esterified or directly substituted with primary and secondary amines. Among the resulting aminomethyl spiroacetals, several ones bearing diamino residues wer...

Ausführliche Beschreibung