New Hydroxamic Acid Derivatives of Fluoroquinolones: Synthesis and Evaluation of Antibacterial and Anticancer Properties

A series of new hydroxamic acid derivatives (6a–f) at C-3 position of fluoroquinolones were designed and synthesized through multistep synthesis. The design concept involved replacement of the 3-carboxylic acid in fluoquinolones with hydroxamic acid as an acid mimicking group. The synthetic work emp...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2014/02/01, Vol.62(2), pp.168-175
Hauptverfasser:	Rajulu, Gavara Govinda, Naik, Halehatty Seephya Bhojya, Viswanadhan, Abhilash, Thiruvengadam, Jayaraman, Rajesh, Kondodiyil, Ganesh, Sambasivam, Jagadheshan, Hiriyan, Kesavan, Poonimangadu Koppolu
Format:	Artikel
Sprache:	eng
Schlagworte:	[1,2,3]triazolyl derivative Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antibacterial activity anticancer activity Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Escherichia coli - drug effects Escherichia coli - growth & development Escherichia coli Infections - drug therapy fluoroquinolone Fluoroquinolones - chemical synthesis Fluoroquinolones - chemistry Fluoroquinolones - pharmacology Humans hydroxamic acid Hydroxamic Acids - chemical synthesis Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacology Klebsiella Infections - drug therapy Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - growth & development Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Neoplasms - drug therapy Structure-Activity Relationship
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