Associations of Pulse Pressure Index With Left Ventricular Filling Pressure and Diastolic Dysfunction in Patients With Chronic Kidney Disease
BACKGROUND Patients with chronic kidney disease (CKD) often have poor vascular compliance and poor left ventricular diastolic dysfunction (LVDD). The pulse pressure index (PPI) defined as ((systolic blood pressure - diastolic blood pressure)/systolic blood pressure) reflects vascular compliance. Vas...
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| Veröffentlicht in: | American journal of hypertension 2014-03, Vol.27 (3), p.454-459 |
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| creator | Lee, Wen-Hsien Hsu, Po-Chao Chu, Chun-Yuan Chen, Szu-Chia Su, Ho-Ming Lin, Tsung-Hsien Lee, Chee-Siong Yen, Hsueh-Wei Voon, Wen-Chol Lai, Wen-Ter Sheu, Sheng-Hsiung |
| description | BACKGROUND
Patients with chronic kidney disease (CKD) often have poor vascular compliance and poor left ventricular diastolic dysfunction (LVDD). The pulse pressure index (PPI) defined as ((systolic blood pressure - diastolic blood pressure)/systolic blood pressure) reflects vascular compliance. Vascular compliance is reportedly associated with left ventricular diastolic function. This study of CKD patients investigated whether PPI correlates with the ratio of transmitral E wave velocity (E) to early diastole mitral annulus velocity (Ea) or with LVDD.
METHODS
This study enrolled 511 CKD patients who had been referred for echocardiographic examination. Blood pressure was automatically measured with an ABI-form device. The LVDD was defined as E-to-transmitral A wave velocity ratio of ≥0.9, Ea |
| doi_str_mv | 10.1093/ajh/hpt228 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1499123348</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ajh/hpt228</oup_id><sourcerecordid>1499123348</sourcerecordid><originalsourceid>FETCH-LOGICAL-c381t-2dff86545fcd02c9f66a4ccb02277473857fad5d0de54208ffebf41cedf24ec43</originalsourceid><addsrcrecordid>eNp90d9qFDEUBvAgFrtWb3wACYggwrRJJpOZuSxbq6UL3Qv_XA7Z5MTNMptscybgPoTvbMpUBS-8Oje_850DHyGvODvnrK8v9G57sT1MQnRPyIL3kletEM1TsmBd31QtU_yUPEfcMcakUvwZORWyFkqwZkF-XiJG4_XkY0AaHV3nEYGuEyDmBPQmWPhBv_lpS1fgJvoVwpS8yaNO9NqPow_f_2IdLL3yGqc4ekOvjuhyMA_J1Ae6LjfKMs5hy22KoaBbbwMcyxaCRnhBTpwu918-zjPy5frD5-WnanX38WZ5uapM3fGpEta5TjWyccYyYXqnlJbGbJgQbSvbumtap21jmYVGCtY5BxsnuQHrhAQj6zPybs49pHifAadh79HAOOoAMePAZd9zUdeyK_TNP3QXcwrlu4ErzhWrVdcX9X5WJkXEBG44JL_X6ThwNjyUNJSShrmkgl8_RubNHuwf-ruVAt7OIObD_4J-AVBznL0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1611603689</pqid></control><display><type>article</type><title>Associations of Pulse Pressure Index With Left Ventricular Filling Pressure and Diastolic Dysfunction in Patients With Chronic Kidney Disease</title><source>MEDLINE</source><source>Oxford Journals Online</source><source>Alma/SFX Local Collection</source><creator>Lee, Wen-Hsien ; Hsu, Po-Chao ; Chu, Chun-Yuan ; Chen, Szu-Chia ; Su, Ho-Ming ; Lin, Tsung-Hsien ; Lee, Chee-Siong ; Yen, Hsueh-Wei ; Voon, Wen-Chol ; Lai, Wen-Ter ; Sheu, Sheng-Hsiung</creator><creatorcontrib>Lee, Wen-Hsien ; Hsu, Po-Chao ; Chu, Chun-Yuan ; Chen, Szu-Chia ; Su, Ho-Ming ; Lin, Tsung-Hsien ; Lee, Chee-Siong ; Yen, Hsueh-Wei ; Voon, Wen-Chol ; Lai, Wen-Ter ; Sheu, Sheng-Hsiung</creatorcontrib><description>BACKGROUND
Patients with chronic kidney disease (CKD) often have poor vascular compliance and poor left ventricular diastolic dysfunction (LVDD). The pulse pressure index (PPI) defined as ((systolic blood pressure - diastolic blood pressure)/systolic blood pressure) reflects vascular compliance. Vascular compliance is reportedly associated with left ventricular diastolic function. This study of CKD patients investigated whether PPI correlates with the ratio of transmitral E wave velocity (E) to early diastole mitral annulus velocity (Ea) or with LVDD.
METHODS
This study enrolled 511 CKD patients who had been referred for echocardiographic examination. Blood pressure was automatically measured with an ABI-form device. The LVDD was defined as E-to-transmitral A wave velocity ratio of ≥0.9, Ea <8cm/s, or E/Ea ≥15.
RESULTS
Compared with those with E/Ea <15, patients with E/Ea ≥15 had significantly higher systolic blood pressure, pulse pressure, and PPI (all P < 0.001). Multivariable analysis showed that PPI was independently associated with E/Ea (unstandardized coefficient β = 1.348; P < 0.001) and with LVDD (odds ratio = 1.441 per 0.064 increase; P < 0.001).
CONCLUSIONS
This study showed that increased PPI significantly correlates with elevated E/Ea and LVDD in CKD patients. Because PPI can be rapidly acquired during blood pressure measurement, it may be helpful for identifying CKD patients with a high left ventricular filling pressure and LVDD.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1093/ajh/hpt228</identifier><identifier>PMID: 24326205</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; Ankle Brachial Index ; Blood Pressure ; Chi-Square Distribution ; Compliance ; Diastole ; Drug therapy ; Echocardiography ; Female ; Humans ; Kidney diseases ; Linear Models ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - diagnosis ; Renal Insufficiency, Chronic - physiopathology ; Risk Factors ; Stroke Volume ; Systole ; Ventricular Dysfunction, Left - diagnosis ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Function, Left ; Ventricular Pressure</subject><ispartof>American journal of hypertension, 2014-03, Vol.27 (3), p.454-459</ispartof><rights>American Journal of Hypertension, Ltd 2013. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2013</rights><rights>American Journal of Hypertension, Ltd 2013. All rights reserved. For Permissions, please email: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-2dff86545fcd02c9f66a4ccb02277473857fad5d0de54208ffebf41cedf24ec43</citedby><cites>FETCH-LOGICAL-c381t-2dff86545fcd02c9f66a4ccb02277473857fad5d0de54208ffebf41cedf24ec43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24326205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Wen-Hsien</creatorcontrib><creatorcontrib>Hsu, Po-Chao</creatorcontrib><creatorcontrib>Chu, Chun-Yuan</creatorcontrib><creatorcontrib>Chen, Szu-Chia</creatorcontrib><creatorcontrib>Su, Ho-Ming</creatorcontrib><creatorcontrib>Lin, Tsung-Hsien</creatorcontrib><creatorcontrib>Lee, Chee-Siong</creatorcontrib><creatorcontrib>Yen, Hsueh-Wei</creatorcontrib><creatorcontrib>Voon, Wen-Chol</creatorcontrib><creatorcontrib>Lai, Wen-Ter</creatorcontrib><creatorcontrib>Sheu, Sheng-Hsiung</creatorcontrib><title>Associations of Pulse Pressure Index With Left Ventricular Filling Pressure and Diastolic Dysfunction in Patients With Chronic Kidney Disease</title><title>American journal of hypertension</title><addtitle>AJHYPE</addtitle><addtitle>Am J Hypertens</addtitle><description>BACKGROUND
Patients with chronic kidney disease (CKD) often have poor vascular compliance and poor left ventricular diastolic dysfunction (LVDD). The pulse pressure index (PPI) defined as ((systolic blood pressure - diastolic blood pressure)/systolic blood pressure) reflects vascular compliance. Vascular compliance is reportedly associated with left ventricular diastolic function. This study of CKD patients investigated whether PPI correlates with the ratio of transmitral E wave velocity (E) to early diastole mitral annulus velocity (Ea) or with LVDD.
METHODS
This study enrolled 511 CKD patients who had been referred for echocardiographic examination. Blood pressure was automatically measured with an ABI-form device. The LVDD was defined as E-to-transmitral A wave velocity ratio of ≥0.9, Ea <8cm/s, or E/Ea ≥15.
RESULTS
Compared with those with E/Ea <15, patients with E/Ea ≥15 had significantly higher systolic blood pressure, pulse pressure, and PPI (all P < 0.001). Multivariable analysis showed that PPI was independently associated with E/Ea (unstandardized coefficient β = 1.348; P < 0.001) and with LVDD (odds ratio = 1.441 per 0.064 increase; P < 0.001).
CONCLUSIONS
This study showed that increased PPI significantly correlates with elevated E/Ea and LVDD in CKD patients. Because PPI can be rapidly acquired during blood pressure measurement, it may be helpful for identifying CKD patients with a high left ventricular filling pressure and LVDD.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Ankle Brachial Index</subject><subject>Blood Pressure</subject><subject>Chi-Square Distribution</subject><subject>Compliance</subject><subject>Diastole</subject><subject>Drug therapy</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Linear Models</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - diagnosis</subject><subject>Renal Insufficiency, Chronic - physiopathology</subject><subject>Risk Factors</subject><subject>Stroke Volume</subject><subject>Systole</subject><subject>Ventricular Dysfunction, Left - diagnosis</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Function, Left</subject><subject>Ventricular Pressure</subject><issn>0895-7061</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp90d9qFDEUBvAgFrtWb3wACYggwrRJJpOZuSxbq6UL3Qv_XA7Z5MTNMptscybgPoTvbMpUBS-8Oje_850DHyGvODvnrK8v9G57sT1MQnRPyIL3kletEM1TsmBd31QtU_yUPEfcMcakUvwZORWyFkqwZkF-XiJG4_XkY0AaHV3nEYGuEyDmBPQmWPhBv_lpS1fgJvoVwpS8yaNO9NqPow_f_2IdLL3yGqc4ekOvjuhyMA_J1Ae6LjfKMs5hy22KoaBbbwMcyxaCRnhBTpwu918-zjPy5frD5-WnanX38WZ5uapM3fGpEta5TjWyccYyYXqnlJbGbJgQbSvbumtap21jmYVGCtY5BxsnuQHrhAQj6zPybs49pHifAadh79HAOOoAMePAZd9zUdeyK_TNP3QXcwrlu4ErzhWrVdcX9X5WJkXEBG44JL_X6ThwNjyUNJSShrmkgl8_RubNHuwf-ruVAt7OIObD_4J-AVBznL0</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Lee, Wen-Hsien</creator><creator>Hsu, Po-Chao</creator><creator>Chu, Chun-Yuan</creator><creator>Chen, Szu-Chia</creator><creator>Su, Ho-Ming</creator><creator>Lin, Tsung-Hsien</creator><creator>Lee, Chee-Siong</creator><creator>Yen, Hsueh-Wei</creator><creator>Voon, Wen-Chol</creator><creator>Lai, Wen-Ter</creator><creator>Sheu, Sheng-Hsiung</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>201403</creationdate><title>Associations of Pulse Pressure Index With Left Ventricular Filling Pressure and Diastolic Dysfunction in Patients With Chronic Kidney Disease</title><author>Lee, Wen-Hsien ; Hsu, Po-Chao ; Chu, Chun-Yuan ; Chen, Szu-Chia ; Su, Ho-Ming ; Lin, Tsung-Hsien ; Lee, Chee-Siong ; Yen, Hsueh-Wei ; Voon, Wen-Chol ; Lai, Wen-Ter ; Sheu, Sheng-Hsiung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-2dff86545fcd02c9f66a4ccb02277473857fad5d0de54208ffebf41cedf24ec43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Ankle Brachial Index</topic><topic>Blood Pressure</topic><topic>Chi-Square Distribution</topic><topic>Compliance</topic><topic>Diastole</topic><topic>Drug therapy</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Linear Models</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - diagnosis</topic><topic>Renal Insufficiency, Chronic - physiopathology</topic><topic>Risk Factors</topic><topic>Stroke Volume</topic><topic>Systole</topic><topic>Ventricular Dysfunction, Left - diagnosis</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Function, Left</topic><topic>Ventricular Pressure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Wen-Hsien</creatorcontrib><creatorcontrib>Hsu, Po-Chao</creatorcontrib><creatorcontrib>Chu, Chun-Yuan</creatorcontrib><creatorcontrib>Chen, Szu-Chia</creatorcontrib><creatorcontrib>Su, Ho-Ming</creatorcontrib><creatorcontrib>Lin, Tsung-Hsien</creatorcontrib><creatorcontrib>Lee, Chee-Siong</creatorcontrib><creatorcontrib>Yen, Hsueh-Wei</creatorcontrib><creatorcontrib>Voon, Wen-Chol</creatorcontrib><creatorcontrib>Lai, Wen-Ter</creatorcontrib><creatorcontrib>Sheu, Sheng-Hsiung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Wen-Hsien</au><au>Hsu, Po-Chao</au><au>Chu, Chun-Yuan</au><au>Chen, Szu-Chia</au><au>Su, Ho-Ming</au><au>Lin, Tsung-Hsien</au><au>Lee, Chee-Siong</au><au>Yen, Hsueh-Wei</au><au>Voon, Wen-Chol</au><au>Lai, Wen-Ter</au><au>Sheu, Sheng-Hsiung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of Pulse Pressure Index With Left Ventricular Filling Pressure and Diastolic Dysfunction in Patients With Chronic Kidney Disease</atitle><jtitle>American journal of hypertension</jtitle><stitle>AJHYPE</stitle><addtitle>Am J Hypertens</addtitle><date>2014-03</date><risdate>2014</risdate><volume>27</volume><issue>3</issue><spage>454</spage><epage>459</epage><pages>454-459</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><coden>AJHYE6</coden><abstract>BACKGROUND
Patients with chronic kidney disease (CKD) often have poor vascular compliance and poor left ventricular diastolic dysfunction (LVDD). The pulse pressure index (PPI) defined as ((systolic blood pressure - diastolic blood pressure)/systolic blood pressure) reflects vascular compliance. Vascular compliance is reportedly associated with left ventricular diastolic function. This study of CKD patients investigated whether PPI correlates with the ratio of transmitral E wave velocity (E) to early diastole mitral annulus velocity (Ea) or with LVDD.
METHODS
This study enrolled 511 CKD patients who had been referred for echocardiographic examination. Blood pressure was automatically measured with an ABI-form device. The LVDD was defined as E-to-transmitral A wave velocity ratio of ≥0.9, Ea <8cm/s, or E/Ea ≥15.
RESULTS
Compared with those with E/Ea <15, patients with E/Ea ≥15 had significantly higher systolic blood pressure, pulse pressure, and PPI (all P < 0.001). Multivariable analysis showed that PPI was independently associated with E/Ea (unstandardized coefficient β = 1.348; P < 0.001) and with LVDD (odds ratio = 1.441 per 0.064 increase; P < 0.001).
CONCLUSIONS
This study showed that increased PPI significantly correlates with elevated E/Ea and LVDD in CKD patients. Because PPI can be rapidly acquired during blood pressure measurement, it may be helpful for identifying CKD patients with a high left ventricular filling pressure and LVDD.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>24326205</pmid><doi>10.1093/ajh/hpt228</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of hypertension, 2014-03, Vol.27 (3), p.454-459 |
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| language | eng |
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| subjects | Aged Aged, 80 and over Ankle Brachial Index Blood Pressure Chi-Square Distribution Compliance Diastole Drug therapy Echocardiography Female Humans Kidney diseases Linear Models Logistic Models Male Middle Aged Multivariate Analysis Odds Ratio Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - physiopathology Risk Factors Stroke Volume Systole Ventricular Dysfunction, Left - diagnosis Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left Ventricular Pressure |
| title | Associations of Pulse Pressure Index With Left Ventricular Filling Pressure and Diastolic Dysfunction in Patients With Chronic Kidney Disease |
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