Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma

BACKGROUND During development, the Hedgehog pathway plays important roles regulating the proliferation and differentiation of chondrocytes, providing a template for growing bone. In this study, the authors investigated the components of dysregulated Hedgehog signaling as potential therapeutic target...

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Veröffentlicht in:	Cancer 2014-02, Vol.120 (4), p.537-547
Hauptverfasser:	Lo, Winnie W., Wunder, Jay S., Dickson, Brendan C., Campbell, Veronica, McGovern, Karen, Alman, Benjamin A., Andrulis, Irene L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antineoplastic Agents - administration & dosage Biological and medical sciences Bone Neoplasms - drug therapy Bone Neoplasms - genetics Bone Neoplasms - pathology Cell Line, Tumor Cell Proliferation - drug effects Child Diseases of the osteoarticular system Female Hedgehog Proteins - genetics Hedgehog Proteins - metabolism hedgehog signaling Humans IPI‐926 Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism ligand‐dependent Male Medical sciences microenvironment Molecular Targeted Therapy Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Nuclear Proteins - genetics Nuclear Proteins - metabolism osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - etiology Osteosarcoma - genetics Osteosarcoma - pathology Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Signal Transduction - drug effects Smoothened Receptor Transcription Factors - genetics Transcription Factors - metabolism Tumors Tumors of striated muscle and skeleton Veratrum Alkaloids - administration & dosage Xenograft Model Antitumor Assays Zinc Finger Protein GLI1 Zinc Finger Protein Gli2
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