Determining factors predictive of CD34+ cell collection efficiency in an effort to avoid extended and repeated apheresis sessions
Introduction: Collection efficiency (CE) is a reflection of the proportion of cells passing through a cell separator that is harvested. The aim of our study was to evaluate which factors influence CE independently in order to find ways to improve CE and therefore minimize the costs and risks of leuk...
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| Veröffentlicht in: | Journal of clinical apheresis 2013-12, Vol.28 (6), p.404-410 |
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| creator | Verlinden, Anke Van de Velde, Ann Verpooten, Gert A. Janssen van Doorn, Karin |
| description | Introduction: Collection efficiency (CE) is a reflection of the proportion of cells passing through a cell separator that is harvested. The aim of our study was to evaluate which factors influence CE independently in order to find ways to improve CE and therefore minimize the costs and risks of leukapheresis and graft processing. Materials and Methods: A total of 206 consecutive apheresis procedures performed on 128 donors/patients were studied retrospectively. We explored the association between CE and the following factors: age, sex, weight, mobilization (granulocyte‐colony‐stimulating factor with or without chemotherapy), collection type (autologous versus allogeneic), venous access (peripheral versus central), total processed blood volume (TPV), hematocrit, white blood cell (WBC) count, thrombocyte count, and peripheral blood CD34+ cell concentration (PBCD34+). Results: Stepwise multiple regression analysis showed WBC count to be the single best predictor of CE, accompanied by TPV. When performing subgroup analysis for autologous apheresis procedures, the inverse correlation of WBC count and TPV with CE becomes stronger (r = −0.563 with P |
| doi_str_mv | 10.1002/jca.21292 |
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The aim of our study was to evaluate which factors influence CE independently in order to find ways to improve CE and therefore minimize the costs and risks of leukapheresis and graft processing. Materials and Methods: A total of 206 consecutive apheresis procedures performed on 128 donors/patients were studied retrospectively. We explored the association between CE and the following factors: age, sex, weight, mobilization (granulocyte‐colony‐stimulating factor with or without chemotherapy), collection type (autologous versus allogeneic), venous access (peripheral versus central), total processed blood volume (TPV), hematocrit, white blood cell (WBC) count, thrombocyte count, and peripheral blood CD34+ cell concentration (PBCD34+). Results: Stepwise multiple regression analysis showed WBC count to be the single best predictor of CE, accompanied by TPV. When performing subgroup analysis for autologous apheresis procedures, the inverse correlation of WBC count and TPV with CE becomes stronger (r = −0.563 with P < 0.001 and r = −0.198 with P = 0.020 respectively), whereas those correlations disappear when analyzing only allogeneic apheresis procedures. Conclusion: The negative correlation between TPV and CE present only in autologous collection procedures can be explained by the limited intra‐apheresis recruitment of CD34+ cells into the blood which is negatively influenced by extensive pre‐treatment. As a result of this study we decided to limit TPV to a maximum of three times the patient's blood volume in autologous apheresis procedures at our center. J. Clin. Apheresis, 28:404–410, 2013. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 0733-2459</identifier><identifier>EISSN: 1098-1101</identifier><identifier>DOI: 10.1002/jca.21292</identifier><identifier>PMID: 24038114</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Allografts ; Antigens, CD34 - analysis ; Blood Cell Count ; Blood Volume ; CD34 ; cell separator ; collection efficiency ; Cytapheresis - economics ; Cytapheresis - statistics & numerical data ; Female ; Hematocrit ; Hematopoietic Stem Cell Mobilization ; Hematopoietic Stem Cells - chemistry ; Humans ; Immunophenotyping ; leukapheresis ; Male ; Middle Aged ; Peripheral Blood Stem Cell Transplantation ; processed blood volume ; Risk Factors ; Transplantation, Autologous ; Young Adult</subject><ispartof>Journal of clinical apheresis, 2013-12, Vol.28 (6), p.404-410</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3912-d14a9cc4dd0cc7a7bc515114abb9ee3a8e066e8120e4f18bee9f081aeb68fd8e3</citedby><cites>FETCH-LOGICAL-c3912-d14a9cc4dd0cc7a7bc515114abb9ee3a8e066e8120e4f18bee9f081aeb68fd8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjca.21292$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjca.21292$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24038114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verlinden, Anke</creatorcontrib><creatorcontrib>Van de Velde, Ann</creatorcontrib><creatorcontrib>Verpooten, Gert A.</creatorcontrib><creatorcontrib>Janssen van Doorn, Karin</creatorcontrib><title>Determining factors predictive of CD34+ cell collection efficiency in an effort to avoid extended and repeated apheresis sessions</title><title>Journal of clinical apheresis</title><addtitle>J. Clin. Apheresis</addtitle><description>Introduction: Collection efficiency (CE) is a reflection of the proportion of cells passing through a cell separator that is harvested. The aim of our study was to evaluate which factors influence CE independently in order to find ways to improve CE and therefore minimize the costs and risks of leukapheresis and graft processing. Materials and Methods: A total of 206 consecutive apheresis procedures performed on 128 donors/patients were studied retrospectively. We explored the association between CE and the following factors: age, sex, weight, mobilization (granulocyte‐colony‐stimulating factor with or without chemotherapy), collection type (autologous versus allogeneic), venous access (peripheral versus central), total processed blood volume (TPV), hematocrit, white blood cell (WBC) count, thrombocyte count, and peripheral blood CD34+ cell concentration (PBCD34+). Results: Stepwise multiple regression analysis showed WBC count to be the single best predictor of CE, accompanied by TPV. When performing subgroup analysis for autologous apheresis procedures, the inverse correlation of WBC count and TPV with CE becomes stronger (r = −0.563 with P < 0.001 and r = −0.198 with P = 0.020 respectively), whereas those correlations disappear when analyzing only allogeneic apheresis procedures. Conclusion: The negative correlation between TPV and CE present only in autologous collection procedures can be explained by the limited intra‐apheresis recruitment of CD34+ cells into the blood which is negatively influenced by extensive pre‐treatment. As a result of this study we decided to limit TPV to a maximum of three times the patient's blood volume in autologous apheresis procedures at our center. J. Clin. Apheresis, 28:404–410, 2013. © 2013 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Allografts</subject><subject>Antigens, CD34 - analysis</subject><subject>Blood Cell Count</subject><subject>Blood Volume</subject><subject>CD34</subject><subject>cell separator</subject><subject>collection efficiency</subject><subject>Cytapheresis - economics</subject><subject>Cytapheresis - statistics & numerical data</subject><subject>Female</subject><subject>Hematocrit</subject><subject>Hematopoietic Stem Cell Mobilization</subject><subject>Hematopoietic Stem Cells - chemistry</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>leukapheresis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peripheral Blood Stem Cell Transplantation</subject><subject>processed blood volume</subject><subject>Risk Factors</subject><subject>Transplantation, Autologous</subject><subject>Young Adult</subject><issn>0733-2459</issn><issn>1098-1101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtvEzEURi0EomlhwR9AltiA0LR-zcPLktLQqgIh8VhaHvsaHCbjwXbaZtl_Xqdpu0BiZdn33HN99SH0ipJDSgg7Whp9yCiT7AmaUSK7ilJCn6IZaTmvmKjlHtpPaUkIkZLXz9EeE4R3lIoZujmBDHHlRz_-wk6bHGLCUwTrTfaXgIPD8xMu3mMDw4BNGAYohTBicM4bD6PZYD9iffcQYsY5YH0ZvMVwnWG0YEvN4ggT6Ly9TL8hQvIJJ0ipiNIL9MzpIcHL-_MAfT_9-G3-qbr4sjibH19UhkvKKkuFlsYIa4kxrW57U9O6rKD7XgJw3QFpGugoIyAc7XoA6UhHNfRN52wH_AC93XmnGP6uIWW18mm7lR4hrJOiQpY5pCFdQd_8gy7DOo7ld4VqRC2oqFmh3u0oE0NKEZyaol_puFGUqG0uquSi7nIp7Ot747pfgX0kH4IowNEOuPIDbP5vUufz4wdltevwKcP1Y4eOf1TT8rZWPz8v1OK0_cC-yh9K8FvyV6c7</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Verlinden, Anke</creator><creator>Van de Velde, Ann</creator><creator>Verpooten, Gert A.</creator><creator>Janssen van Doorn, Karin</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201312</creationdate><title>Determining factors predictive of CD34+ cell collection efficiency in an effort to avoid extended and repeated apheresis sessions</title><author>Verlinden, Anke ; Van de Velde, Ann ; Verpooten, Gert A. ; Janssen van Doorn, Karin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3912-d14a9cc4dd0cc7a7bc515114abb9ee3a8e066e8120e4f18bee9f081aeb68fd8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Allografts</topic><topic>Antigens, CD34 - analysis</topic><topic>Blood Cell Count</topic><topic>Blood Volume</topic><topic>CD34</topic><topic>cell separator</topic><topic>collection efficiency</topic><topic>Cytapheresis - economics</topic><topic>Cytapheresis - statistics & numerical data</topic><topic>Female</topic><topic>Hematocrit</topic><topic>Hematopoietic Stem Cell Mobilization</topic><topic>Hematopoietic Stem Cells - chemistry</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>leukapheresis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Peripheral Blood Stem Cell Transplantation</topic><topic>processed blood volume</topic><topic>Risk Factors</topic><topic>Transplantation, Autologous</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verlinden, Anke</creatorcontrib><creatorcontrib>Van de Velde, Ann</creatorcontrib><creatorcontrib>Verpooten, Gert A.</creatorcontrib><creatorcontrib>Janssen van Doorn, Karin</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical apheresis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verlinden, Anke</au><au>Van de Velde, Ann</au><au>Verpooten, Gert A.</au><au>Janssen van Doorn, Karin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determining factors predictive of CD34+ cell collection efficiency in an effort to avoid extended and repeated apheresis sessions</atitle><jtitle>Journal of clinical apheresis</jtitle><addtitle>J. Clin. Apheresis</addtitle><date>2013-12</date><risdate>2013</risdate><volume>28</volume><issue>6</issue><spage>404</spage><epage>410</epage><pages>404-410</pages><issn>0733-2459</issn><eissn>1098-1101</eissn><abstract>Introduction: Collection efficiency (CE) is a reflection of the proportion of cells passing through a cell separator that is harvested. The aim of our study was to evaluate which factors influence CE independently in order to find ways to improve CE and therefore minimize the costs and risks of leukapheresis and graft processing. Materials and Methods: A total of 206 consecutive apheresis procedures performed on 128 donors/patients were studied retrospectively. We explored the association between CE and the following factors: age, sex, weight, mobilization (granulocyte‐colony‐stimulating factor with or without chemotherapy), collection type (autologous versus allogeneic), venous access (peripheral versus central), total processed blood volume (TPV), hematocrit, white blood cell (WBC) count, thrombocyte count, and peripheral blood CD34+ cell concentration (PBCD34+). Results: Stepwise multiple regression analysis showed WBC count to be the single best predictor of CE, accompanied by TPV. When performing subgroup analysis for autologous apheresis procedures, the inverse correlation of WBC count and TPV with CE becomes stronger (r = −0.563 with P < 0.001 and r = −0.198 with P = 0.020 respectively), whereas those correlations disappear when analyzing only allogeneic apheresis procedures. Conclusion: The negative correlation between TPV and CE present only in autologous collection procedures can be explained by the limited intra‐apheresis recruitment of CD34+ cells into the blood which is negatively influenced by extensive pre‐treatment. As a result of this study we decided to limit TPV to a maximum of three times the patient's blood volume in autologous apheresis procedures at our center. J. Clin. Apheresis, 28:404–410, 2013. © 2013 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24038114</pmid><doi>10.1002/jca.21292</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Allografts Antigens, CD34 - analysis Blood Cell Count Blood Volume CD34 cell separator collection efficiency Cytapheresis - economics Cytapheresis - statistics & numerical data Female Hematocrit Hematopoietic Stem Cell Mobilization Hematopoietic Stem Cells - chemistry Humans Immunophenotyping leukapheresis Male Middle Aged Peripheral Blood Stem Cell Transplantation processed blood volume Risk Factors Transplantation, Autologous Young Adult |
| title | Determining factors predictive of CD34+ cell collection efficiency in an effort to avoid extended and repeated apheresis sessions |
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