Single Center Experience of Cell-Free and Concentrated Ascites Reinfusion Therapy in Malignancy Related Ascites

Cell‐Free and Concentrated Ascites Reinfusion Therapy (CART) is expected to improve patients’ symptoms related to ascites. Use of a patient's own proteins in ascites might reduce the risk of infection. However, several reports have described that reinfusion of concentrated ascites might elevate...

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Veröffentlicht in:Therapeutic apheresis and dialysis 2014-02, Vol.18 (1), p.87-92
Hauptverfasser: Ito, Tetsuya, Hanafusa, Norio, Fukui, Mieko, Yamamoto, Hiroko, Watanabe, Yasuyuki, Noiri, Eisei, Iwase, Satoru, Miyagawa, Kiyoshi, Fujita, Toshiro, Nangaku, Masaomi
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container_issue 1
container_start_page 87
container_title Therapeutic apheresis and dialysis
container_volume 18
creator Ito, Tetsuya
Hanafusa, Norio
Fukui, Mieko
Yamamoto, Hiroko
Watanabe, Yasuyuki
Noiri, Eisei
Iwase, Satoru
Miyagawa, Kiyoshi
Fujita, Toshiro
Nangaku, Masaomi
description Cell‐Free and Concentrated Ascites Reinfusion Therapy (CART) is expected to improve patients’ symptoms related to ascites. Use of a patient's own proteins in ascites might reduce the risk of infection. However, several reports have described that reinfusion of concentrated ascites might elevate body temperature. The aim of this study is to examine the safety and efficacy of the CART system performed exclusively on patients with malignancies. In this retrospective cohort observational study, we examined 81 CART processes performed on 24 patients with malignancies. Data were collected from medical records and records during processing of ascites. We investigated the effectiveness and adverse events during the procedures. The amount of ascites processed was 2.6 ± 1.4 L on average. The concentration ratio was 9.31 ± 5.45 on average. We found an increase in the urine volume after the procedure, which was significantly related to the amount of reinfused protein. The body temperature increased by 0.44°C. Systolic blood pressure decreased by 4 mm Hg after paracentesis, but no significant difference was found between the pressure before paracentesis and after reinfusion. In platelet counts, no significant change was observed. After all, no clinically significant adverse event was confirmed during CART procedures. Results show that CART can be performed safely even on patients with malignancy‐related ascites and that the procedure might improve diuresis.
doi_str_mv 10.1111/1744-9987.12049
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Use of a patient's own proteins in ascites might reduce the risk of infection. However, several reports have described that reinfusion of concentrated ascites might elevate body temperature. The aim of this study is to examine the safety and efficacy of the CART system performed exclusively on patients with malignancies. In this retrospective cohort observational study, we examined 81 CART processes performed on 24 patients with malignancies. Data were collected from medical records and records during processing of ascites. We investigated the effectiveness and adverse events during the procedures. The amount of ascites processed was 2.6 ± 1.4 L on average. The concentration ratio was 9.31 ± 5.45 on average. We found an increase in the urine volume after the procedure, which was significantly related to the amount of reinfused protein. The body temperature increased by 0.44°C. Systolic blood pressure decreased by 4 mm Hg after paracentesis, but no significant difference was found between the pressure before paracentesis and after reinfusion. In platelet counts, no significant change was observed. After all, no clinically significant adverse event was confirmed during CART procedures. 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Systolic blood pressure decreased by 4 mm Hg after paracentesis, but no significant difference was found between the pressure before paracentesis and after reinfusion. In platelet counts, no significant change was observed. After all, no clinically significant adverse event was confirmed during CART procedures. 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identifier ISSN: 1744-9979
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1744-9987
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source MEDLINE; Access via Wiley Online Library
subjects Aged
Ascites
Ascites - etiology
Ascites - therapy
Ascitic Fluid - chemistry
Blood Pressure
Body Temperature
Cell-Free and Concentrated Ascites Reinfusion Therapy
Cell-Free System
Cohort Studies
Efficacy
Female
Humans
Male
Middle Aged
Neoplasm
Neoplasms - complications
Plasmapheresis
Platelet Count
Proteins - chemistry
Retrospective Studies
Safety
title Single Center Experience of Cell-Free and Concentrated Ascites Reinfusion Therapy in Malignancy Related Ascites
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