Cerebrospinal Fluid Aβ42, Phosphorylated Tau181, and Resting-State Functional Connectivity

IMPORTANCE Resting-state functional connectivity magnetic resonance imaging has great potential for characterizing pathophysiological changes during the preclinical phase of Alzheimer disease. OBJECTIVE To assess the relationship between default mode network integrity and cerebrospinal fluid biomark...

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Veröffentlicht in:	JAMA neurology 2013-10, Vol.70 (10), p.1242-1248
Hauptverfasser:	Wang, Liang, Brier, Matthew R, Snyder, Abraham Z, Thomas, Jewell B, Fagan, Anne M, Xiong, Chengjie, Benzinger, Tammie L, Holtzman, David M, Morris, John C, Ances, Beau M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Amyloid beta-Peptides - cerebrospinal fluid Apolipoproteins E - genetics Brain - blood supply Brain - physiology Brain Mapping Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Oxygen - blood Peptide Fragments - cerebrospinal fluid Phosphorylation Residence Characteristics Rest - physiology Statistics, Nonparametric tau Proteins - cerebrospinal fluid Threonine - metabolism
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