Effect of binders on the release rates of direct molded verapamil tablets using twin-screw extruder in melt granulation

Conventional manufacturing of pharmaceutical tablets often involves single processes such as blending, granulation, milling and direct compression. A process that minimizes and incorporates all these in a single continuous step is desirable. The concept of omitting milling step followed by direct-mo...

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Veröffentlicht in:	International journal of pharmaceutics 2014-03, Vol.463 (1), p.89-97
Hauptverfasser:	Tan, David Cheng Thiam, Chin, William Wei Lim, Tan, En Hui, Hong, Shiqi, Gu, Wei, Gokhale, Rajeev
Format:	Artikel
Sprache:	eng
Schlagworte:	Direct mold Excipients - chemistry Hot melt extruder Hydrophilic Hydrophobic Hydrophobic and Hydrophilic Interactions Melt granulation Modified release Polymers - chemistry Tablets Technology, Pharmaceutical - methods Verapamil - chemistry
Online-Zugang:	Volltext
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