Smoothened inhibitors in the treatment of advanced basal cell carcinomas

PURPOSE OF REVIEWThe Hedgehog pathway has been identified as a key element in the development of many forms of cancer. Smoothened (Smo) inhibitors are known to beneficially interfere with the Hedgehog pathway and are currently under investigation as anticancer drugs for many tumor entities. Reviewed...

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Veröffentlicht in:	Current opinion in oncology 2014-03, Vol.26 (2), p.184-195
1. Verfasser:	Kunstfeld, Rainer
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilides - therapeutic use Carcinoma, Basal Cell - drug therapy Carcinoma, Basal Cell - metabolism Hedgehog Proteins - metabolism Humans Pyridines - therapeutic use Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - metabolism Signal Transduction - drug effects Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Smoothened Receptor Survival Analysis Treatment Outcome
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