Two Related Pyrrolidinedione Synthetase Loci in Fusarium heterosporum ATCC 74349 Produce Divergent Metabolites

Equisetin synthetase (EqiS), from the filamentous fungus Fusarium heterosporum ATCC 74349, was initially assigned on the basis of genetic knockout and expression analysis. Increasing inconsistencies in experimental results led us to question this assignment. Here, we sequenced the F. heterosporum ge...

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Veröffentlicht in:	ACS chemical biology 2013-07, Vol.8 (7), p.1549-1557
Hauptverfasser:	Kakule, Thomas B, Sardar, Debosmita, Lin, Zhenjian, Schmidt, Eric W
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Chromatography, High Pressure Liquid Cloning, Molecular Fusarium - chemistry Fusarium - enzymology Fusarium - genetics Gene Knockout Techniques Ligases - genetics Ligases - metabolism Magnetic Resonance Spectroscopy Molecular Structure Pyrrolidines - chemistry Pyrrolidines - metabolism Pyrrolidinones - chemistry Pyrrolidinones - metabolism Tetrahydronaphthalenes - chemistry Tetrahydronaphthalenes - metabolism
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