Effects of E-64, a cysteine proteinase inhibitor, on cowpea weevil growth, development, and fecundity
E-64, a specific inhibitor of cysteine proteinases, was incorporated into artificial seeds at low levels (0.01-0.25% by weight). It prolonged developmental time and increased mortality of the larval cowpea weevil, Callosobruchus maculatus (F.), in direct proportion to its concentration in the artifi...
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| Veröffentlicht in: | Environ. Entomol.; (United States) 1988-06, Vol.17 (3), p.467-469 |
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| container_title | Environ. Entomol.; (United States) |
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| creator | MURDOCK, L. L SHADE, R. E POMEROY, M. A |
| description | E-64, a specific inhibitor of cysteine proteinases, was incorporated into artificial seeds at low levels (0.01-0.25% by weight). It prolonged developmental time and increased mortality of the larval cowpea weevil, Callosobruchus maculatus (F.), in direct proportion to its concentration in the artificial seeds. The fecundity of females emerging from the artificial seeds was significantly decreased by E-64 concentrations of 0.06% and higher. These observations are compatible with the hypothesis that the midgut cysteine proteinase in C. maculatus is essential for normal growth and development. |
| doi_str_mv | 10.1093/ee/17.3.467 |
| format | Article |
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L ; SHADE, R. E ; POMEROY, M. A</creator><creatorcontrib>MURDOCK, L. L ; SHADE, R. E ; POMEROY, M. A ; Purdue Univ., West Lafayette, IN (USA)</creatorcontrib><description>E-64, a specific inhibitor of cysteine proteinases, was incorporated into artificial seeds at low levels (0.01-0.25% by weight). It prolonged developmental time and increased mortality of the larval cowpea weevil, Callosobruchus maculatus (F.), in direct proportion to its concentration in the artificial seeds. The fecundity of females emerging from the artificial seeds was significantly decreased by E-64 concentrations of 0.06% and higher. These observations are compatible with the hypothesis that the midgut cysteine proteinase in C. maculatus is essential for normal growth and development.</description><identifier>ISSN: 0046-225X</identifier><identifier>EISSN: 1938-2936</identifier><identifier>DOI: 10.1093/ee/17.3.467</identifier><identifier>CODEN: EVETBX</identifier><language>eng</language><publisher>Lanham, MD: Entomological Society of America</publisher><subject>AMINO ACIDS ; ANIMALS ; ARTHROPODS ; BASIC BIOLOGICAL SCIENCES ; BEETLES ; Biochemistry. Physiology. Immunology ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; Bruchidae ; callosobruchus ; CARBOXYLIC ACIDS ; cisteina ; COLEOPTERA ; crecimiento ; croissance ; CYSTEINE ; DIET ; digestion ; ENZYME INHIBITORS ; ENZYMES ; fecondite ; fecundidad ; fecundity ; Fundamental and applied biological sciences. Psychology ; GROWTH ; HYDROLASES ; inhibidores de enzimas ; inhibiteur d' enzyme ; Insecta ; INSECTS ; INVERTEBRATES ; LARVAE ; METABOLISM ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANIC SULFUR COMPOUNDS ; PEPTIDE HYDROLASES ; Physiology. Development ; proteasas ; protease ; proteases ; proteinas ; proteine ; proteins ; SEEDS ; THIOLS 550500 -- Metabolism</subject><ispartof>Environ. Entomol.; (United States), 1988-06, Vol.17 (3), p.467-469</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-640ee7f9f51d8679215609cdf63d7431a1efacf0c7f01e9747f7c2d73a752a3b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7005211$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6864325$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>MURDOCK, L. L</creatorcontrib><creatorcontrib>SHADE, R. E</creatorcontrib><creatorcontrib>POMEROY, M. A</creatorcontrib><creatorcontrib>Purdue Univ., West Lafayette, IN (USA)</creatorcontrib><title>Effects of E-64, a cysteine proteinase inhibitor, on cowpea weevil growth, development, and fecundity</title><title>Environ. Entomol.; (United States)</title><description>E-64, a specific inhibitor of cysteine proteinases, was incorporated into artificial seeds at low levels (0.01-0.25% by weight). It prolonged developmental time and increased mortality of the larval cowpea weevil, Callosobruchus maculatus (F.), in direct proportion to its concentration in the artificial seeds. The fecundity of females emerging from the artificial seeds was significantly decreased by E-64 concentrations of 0.06% and higher. These observations are compatible with the hypothesis that the midgut cysteine proteinase in C. maculatus is essential for normal growth and development.</description><subject>AMINO ACIDS</subject><subject>ANIMALS</subject><subject>ARTHROPODS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BEETLES</subject><subject>Biochemistry. Physiology. Immunology</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>Bruchidae</subject><subject>callosobruchus</subject><subject>CARBOXYLIC ACIDS</subject><subject>cisteina</subject><subject>COLEOPTERA</subject><subject>crecimiento</subject><subject>croissance</subject><subject>CYSTEINE</subject><subject>DIET</subject><subject>digestion</subject><subject>ENZYME INHIBITORS</subject><subject>ENZYMES</subject><subject>fecondite</subject><subject>fecundidad</subject><subject>fecundity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GROWTH</subject><subject>HYDROLASES</subject><subject>inhibidores de enzimas</subject><subject>inhibiteur d' enzyme</subject><subject>Insecta</subject><subject>INSECTS</subject><subject>INVERTEBRATES</subject><subject>LARVAE</subject><subject>METABOLISM</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC SULFUR COMPOUNDS</subject><subject>PEPTIDE HYDROLASES</subject><subject>Physiology. Development</subject><subject>proteasas</subject><subject>protease</subject><subject>proteases</subject><subject>proteinas</subject><subject>proteine</subject><subject>proteins</subject><subject>SEEDS</subject><subject>THIOLS 550500 -- Metabolism</subject><issn>0046-225X</issn><issn>1938-2936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><recordid>eNo9kEFrGzEQRkVpoW7aU-9FlNJLvI5G2pVWxxKctBDoIQn0JhTtKFZZS64kx_jfR8Ghc5k5vHnDfIR8BrYCpsUF4gWolVj1Ur0hC9Bi7LgW8i1ZMNbLjvPhz3vyoZS_rNXI1YLg2nt0tdDk6bqT_ZJa6o6lYohIdzm9DLYgDXETHkJNeUlTpC4ddmjpAfEpzPQxp0PdLOmETzin3RZjbZo40WbexynU40fyztu54KfXfkbur9Z3lz-7m9_Xvy5_3HROCF3beYaovPYDTKNUmsMgmXaTl2JSvQAL6K3zzCnPALXqlVeOT0pYNXArHsQZ-XryplKDKS5UdBuXYmwvGjnKXvChQd9PUHvv3x5LNdtQHM6zjZj2xUCvx1GCaOD5CXQ5lZLRm10OW5uPBph5ydsgGlBGmJZ3o7-9am1xdvbZRhfK_xXF2MABGvblhHmbjH3MDbm_BT1qxjSAYuIZpC6IQA</recordid><startdate>19880601</startdate><enddate>19880601</enddate><creator>MURDOCK, L. L</creator><creator>SHADE, R. E</creator><creator>POMEROY, M. A</creator><general>Entomological Society of America</general><scope>FBQ</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>OTOTI</scope></search><sort><creationdate>19880601</creationdate><title>Effects of E-64, a cysteine proteinase inhibitor, on cowpea weevil growth, development, and fecundity</title><author>MURDOCK, L. L ; SHADE, R. E ; POMEROY, M. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-640ee7f9f51d8679215609cdf63d7431a1efacf0c7f01e9747f7c2d73a752a3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>AMINO ACIDS</topic><topic>ANIMALS</topic><topic>ARTHROPODS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BEETLES</topic><topic>Biochemistry. Physiology. Immunology</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>Bruchidae</topic><topic>callosobruchus</topic><topic>CARBOXYLIC ACIDS</topic><topic>cisteina</topic><topic>COLEOPTERA</topic><topic>crecimiento</topic><topic>croissance</topic><topic>CYSTEINE</topic><topic>DIET</topic><topic>digestion</topic><topic>ENZYME INHIBITORS</topic><topic>ENZYMES</topic><topic>fecondite</topic><topic>fecundidad</topic><topic>fecundity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GROWTH</topic><topic>HYDROLASES</topic><topic>inhibidores de enzimas</topic><topic>inhibiteur d' enzyme</topic><topic>Insecta</topic><topic>INSECTS</topic><topic>INVERTEBRATES</topic><topic>LARVAE</topic><topic>METABOLISM</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC SULFUR COMPOUNDS</topic><topic>PEPTIDE HYDROLASES</topic><topic>Physiology. Development</topic><topic>proteasas</topic><topic>protease</topic><topic>proteases</topic><topic>proteinas</topic><topic>proteine</topic><topic>proteins</topic><topic>SEEDS</topic><topic>THIOLS 550500 -- Metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MURDOCK, L. L</creatorcontrib><creatorcontrib>SHADE, R. E</creatorcontrib><creatorcontrib>POMEROY, M. A</creatorcontrib><creatorcontrib>Purdue Univ., West Lafayette, IN (USA)</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>OSTI.GOV</collection><jtitle>Environ. Entomol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MURDOCK, L. L</au><au>SHADE, R. E</au><au>POMEROY, M. A</au><aucorp>Purdue Univ., West Lafayette, IN (USA)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of E-64, a cysteine proteinase inhibitor, on cowpea weevil growth, development, and fecundity</atitle><jtitle>Environ. Entomol.; (United States)</jtitle><date>1988-06-01</date><risdate>1988</risdate><volume>17</volume><issue>3</issue><spage>467</spage><epage>469</epage><pages>467-469</pages><issn>0046-225X</issn><eissn>1938-2936</eissn><coden>EVETBX</coden><abstract>E-64, a specific inhibitor of cysteine proteinases, was incorporated into artificial seeds at low levels (0.01-0.25% by weight). It prolonged developmental time and increased mortality of the larval cowpea weevil, Callosobruchus maculatus (F.), in direct proportion to its concentration in the artificial seeds. The fecundity of females emerging from the artificial seeds was significantly decreased by E-64 concentrations of 0.06% and higher. These observations are compatible with the hypothesis that the midgut cysteine proteinase in C. maculatus is essential for normal growth and development.</abstract><cop>Lanham, MD</cop><pub>Entomological Society of America</pub><doi>10.1093/ee/17.3.467</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0046-225X |
| ispartof | Environ. Entomol.; (United States), 1988-06, Vol.17 (3), p.467-469 |
| issn | 0046-225X 1938-2936 |
| language | eng |
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| source | Oxford University Press Journals Digital Archive legacy |
| subjects | AMINO ACIDS ANIMALS ARTHROPODS BASIC BIOLOGICAL SCIENCES BEETLES Biochemistry. Physiology. Immunology Biological and medical sciences BIOLOGICAL EFFECTS Bruchidae callosobruchus CARBOXYLIC ACIDS cisteina COLEOPTERA crecimiento croissance CYSTEINE DIET digestion ENZYME INHIBITORS ENZYMES fecondite fecundidad fecundity Fundamental and applied biological sciences. Psychology GROWTH HYDROLASES inhibidores de enzimas inhibiteur d' enzyme Insecta INSECTS INVERTEBRATES LARVAE METABOLISM ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC SULFUR COMPOUNDS PEPTIDE HYDROLASES Physiology. Development proteasas protease proteases proteinas proteine proteins SEEDS THIOLS 550500 -- Metabolism |
| title | Effects of E-64, a cysteine proteinase inhibitor, on cowpea weevil growth, development, and fecundity |
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