Enzymatic Production of Ribavirin from Pyrimidine Nucleosides by Enterobacter aerogenes AJ 11125
Microorganisms that produce ribavirin(1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide; virazole ® ) directly from pyrimidine nucleosides and TCA (1,2,4-triazole-3-carboxamide) were screened from our stock cultures. Of the 400 strains tested, 16 were isolated as ribavirin-producers from uridine or c...
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| Veröffentlicht in: | Agricultural and biological chemistry 1988-05, Vol.52 (5), p.1233-1237 |
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| container_title | Agricultural and biological chemistry |
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| creator | Shirae, Hideyuki Yokozeki, Kenzo Kubota, Koji |
| description | Microorganisms that produce ribavirin(1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide; virazole
®
) directly from pyrimidine nucleosides and TCA (1,2,4-triazole-3-carboxamide) were screened from our stock cultures. Of the 400 strains tested, 16 were isolated as ribavirin-producers from uridine or cytidine. In particular, Enterobacter aerogenes AJ 11125, Bacillus brevis AJ 1282 and Sarcina lutea AJ 1212 were found to possess potent activities of ribavirin production from them. In the presence of intact cells of Enterobacter aerogenes AJ 11125, which was selected as the best strain, 110.2mm and 67.6 mm ribavirin were produced from uridine and cytidine, respectively, on 96 hr reaction at 60°C. In addition, this strain could also produce ribavirin from guanosine, but could not produce it from orotidine, which is also a pyrimidine nucleoside. |
| doi_str_mv | 10.1080/00021369.1988.10868841 |
| format | Article |
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®
) directly from pyrimidine nucleosides and TCA (1,2,4-triazole-3-carboxamide) were screened from our stock cultures. Of the 400 strains tested, 16 were isolated as ribavirin-producers from uridine or cytidine. In particular, Enterobacter aerogenes AJ 11125, Bacillus brevis AJ 1282 and Sarcina lutea AJ 1212 were found to possess potent activities of ribavirin production from them. In the presence of intact cells of Enterobacter aerogenes AJ 11125, which was selected as the best strain, 110.2mm and 67.6 mm ribavirin were produced from uridine and cytidine, respectively, on 96 hr reaction at 60°C. In addition, this strain could also produce ribavirin from guanosine, but could not produce it from orotidine, which is also a pyrimidine nucleoside.</description><identifier>ISSN: 0002-1369</identifier><identifier>DOI: 10.1080/00021369.1988.10868841</identifier><identifier>CODEN: ABCHA6</identifier><language>eng</language><publisher>Tokyo: Taylor & Francis</publisher><subject>1,2,4-triazole-3-carboxamide ; Bacteriology ; Bioconversions. Hemisynthesis ; Biological and medical sciences ; Biotechnology ; cytidine ; Enterobacter aerogenes ; Fundamental and applied biological sciences. Psychology ; Metabolism. Enzymes ; Methods. Procedures. Technologies ; Microbiology ; ribavirin ; uridine</subject><ispartof>Agricultural and biological chemistry, 1988-05, Vol.52 (5), p.1233-1237</ispartof><rights>Copyright, 1988, by the Agricultural Chemical Society of Japan 1988</rights><rights>1988 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7787927$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Shirae, Hideyuki</creatorcontrib><creatorcontrib>Yokozeki, Kenzo</creatorcontrib><creatorcontrib>Kubota, Koji</creatorcontrib><title>Enzymatic Production of Ribavirin from Pyrimidine Nucleosides by Enterobacter aerogenes AJ 11125</title><title>Agricultural and biological chemistry</title><description>Microorganisms that produce ribavirin(1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide; virazole
®
) directly from pyrimidine nucleosides and TCA (1,2,4-triazole-3-carboxamide) were screened from our stock cultures. Of the 400 strains tested, 16 were isolated as ribavirin-producers from uridine or cytidine. In particular, Enterobacter aerogenes AJ 11125, Bacillus brevis AJ 1282 and Sarcina lutea AJ 1212 were found to possess potent activities of ribavirin production from them. In the presence of intact cells of Enterobacter aerogenes AJ 11125, which was selected as the best strain, 110.2mm and 67.6 mm ribavirin were produced from uridine and cytidine, respectively, on 96 hr reaction at 60°C. In addition, this strain could also produce ribavirin from guanosine, but could not produce it from orotidine, which is also a pyrimidine nucleoside.</description><subject>1,2,4-triazole-3-carboxamide</subject><subject>Bacteriology</subject><subject>Bioconversions. Hemisynthesis</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>cytidine</subject><subject>Enterobacter aerogenes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Metabolism. Enzymes</subject><subject>Methods. Procedures. Technologies</subject><subject>Microbiology</subject><subject>ribavirin</subject><subject>uridine</subject><issn>0002-1369</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><recordid>eNqFkMlOwzAQhnMAibK8AvIBcWvxksT2sarKpgoqBGfj2A4ySuxiJ6Dw9Dhqy7WnsfwvM_qy7BLBGYIM3kAIMSIlnyHO2PhVMpajo2wyCtNROclOY_yEsIAEwkn2vnS_Qys7q8A6eN2rznoHfA1ebCW_bbAO1MG3YD0E21ptnQFPvWqMj1abCKoBLF1ngq-kSgPI9PwwLinzR4AQwsV5dlzLJpqL3TzL3m6Xr4v76er57mExX00VZqibIqOxNlxTXkFWKcKl4phpidL9mBNe45ywAhW6YqU0vMwx4rQsSF4ZWdM8J2fZ9bZ3E_xXb2InWhuVaRrpjO-jQAUiDHJ22JinYkLHxnJrVMHHGEwtNomBDINAUIy0xZ62GGmLPe0UvNptkFHJpg7SKRv_05QyyjFNtvnWZl3tQyt_fGi06OTQ-LDPkAOr_gBAppTC</recordid><startdate>19880501</startdate><enddate>19880501</enddate><creator>Shirae, Hideyuki</creator><creator>Yokozeki, Kenzo</creator><creator>Kubota, Koji</creator><general>Taylor & Francis</general><general>Agricultural Chemical Society of Japan</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>19880501</creationdate><title>Enzymatic Production of Ribavirin from Pyrimidine Nucleosides by Enterobacter aerogenes AJ 11125</title><author>Shirae, Hideyuki ; Yokozeki, Kenzo ; Kubota, Koji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-1ed2de9d79b08bc39ac928da18842939f2438515db86ae96421976534beaf7443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>1,2,4-triazole-3-carboxamide</topic><topic>Bacteriology</topic><topic>Bioconversions. Hemisynthesis</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>cytidine</topic><topic>Enterobacter aerogenes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Metabolism. Enzymes</topic><topic>Methods. Procedures. Technologies</topic><topic>Microbiology</topic><topic>ribavirin</topic><topic>uridine</topic><toplevel>online_resources</toplevel><creatorcontrib>Shirae, Hideyuki</creatorcontrib><creatorcontrib>Yokozeki, Kenzo</creatorcontrib><creatorcontrib>Kubota, Koji</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Agricultural and biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shirae, Hideyuki</au><au>Yokozeki, Kenzo</au><au>Kubota, Koji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enzymatic Production of Ribavirin from Pyrimidine Nucleosides by Enterobacter aerogenes AJ 11125</atitle><jtitle>Agricultural and biological chemistry</jtitle><date>1988-05-01</date><risdate>1988</risdate><volume>52</volume><issue>5</issue><spage>1233</spage><epage>1237</epage><pages>1233-1237</pages><issn>0002-1369</issn><coden>ABCHA6</coden><abstract>Microorganisms that produce ribavirin(1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide; virazole
®
) directly from pyrimidine nucleosides and TCA (1,2,4-triazole-3-carboxamide) were screened from our stock cultures. Of the 400 strains tested, 16 were isolated as ribavirin-producers from uridine or cytidine. In particular, Enterobacter aerogenes AJ 11125, Bacillus brevis AJ 1282 and Sarcina lutea AJ 1212 were found to possess potent activities of ribavirin production from them. In the presence of intact cells of Enterobacter aerogenes AJ 11125, which was selected as the best strain, 110.2mm and 67.6 mm ribavirin were produced from uridine and cytidine, respectively, on 96 hr reaction at 60°C. In addition, this strain could also produce ribavirin from guanosine, but could not produce it from orotidine, which is also a pyrimidine nucleoside.</abstract><cop>Tokyo</cop><pub>Taylor & Francis</pub><doi>10.1080/00021369.1988.10868841</doi><tpages>5</tpages></addata></record> |
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| ispartof | Agricultural and biological chemistry, 1988-05, Vol.52 (5), p.1233-1237 |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| subjects | 1,2,4-triazole-3-carboxamide Bacteriology Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology cytidine Enterobacter aerogenes Fundamental and applied biological sciences. Psychology Metabolism. Enzymes Methods. Procedures. Technologies Microbiology ribavirin uridine |
| title | Enzymatic Production of Ribavirin from Pyrimidine Nucleosides by Enterobacter aerogenes AJ 11125 |
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