Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements
Since bacteria were found to contain genes encoding enzymes that synthesize a plethora of potential secondary metabolites, interest has grown in the activation of these cryptic pathways. Homologous and heterologous expression of these cryptic secondary metabolite-biosynthetic genes, often “silent” u...
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| Veröffentlicht in: | Journal of industrial microbiology & biotechnology 2014-02, Vol.41 (2), p.403-414 |
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| container_title | Journal of industrial microbiology & biotechnology |
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| creator | Ochi, Kozo Tanaka, Yukinori Tojo, Shigeo |
| description | Since bacteria were found to contain genes encoding enzymes that synthesize a plethora of potential secondary metabolites, interest has grown in the activation of these cryptic pathways. Homologous and heterologous expression of these cryptic secondary metabolite-biosynthetic genes, often “silent” under ordinary laboratory fermentation conditions, may lead to the discovery of novel secondary metabolites. We review current progress on this topic, describing concepts for activating silent genes. We especially focus on genetic manipulation of transcription and translation, as well as the utilization of rare earth elements as a novel method to activate the silent genes. The possible roles of silent genes in bacterial physiology are also discussed. |
| doi_str_mv | 10.1007/s10295-013-1349-4 |
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Homologous and heterologous expression of these cryptic secondary metabolite-biosynthetic genes, often “silent” under ordinary laboratory fermentation conditions, may lead to the discovery of novel secondary metabolites. We review current progress on this topic, describing concepts for activating silent genes. We especially focus on genetic manipulation of transcription and translation, as well as the utilization of rare earth elements as a novel method to activate the silent genes. The possible roles of silent genes in bacterial physiology are also discussed.</description><identifier>ISSN: 1367-5435</identifier><identifier>EISSN: 1476-5535</identifier><identifier>DOI: 10.1007/s10295-013-1349-4</identifier><identifier>PMID: 24127067</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Antibiotics ; Bacteria ; Bacteria - genetics ; Bacteria - metabolism ; Bacterial physiology ; Biochemistry ; Bioinformatics ; Biomedical and Life Sciences ; Biosynthesis ; Biotechnology ; Carbon ; DNA-Directed RNA Polymerases - genetics ; DNA-Directed RNA Polymerases - metabolism ; Enzymes ; Fatty acids ; Fermentation ; Gene expression ; Gene Expression Regulation, Bacterial ; Gene Silencing ; Genes ; Genetic Engineering ; Genomes ; Genomics ; Inorganic Chemistry ; Life Sciences ; Metabolism ; Metabolites ; Metals, Rare Earth - pharmacology ; Methods ; Microbiology ; Mutation ; Natural products ; Organic chemicals ; Proteins ; Rare earth elements ; Review ; Ribonucleic acid ; RNA ; RNA polymerase ; Secondary Metabolism - genetics ; Secondary metabolites ; Studies ; Trace elements ; Transcriptional Activation ; Vegetable oils</subject><ispartof>Journal of industrial microbiology & biotechnology, 2014-02, Vol.41 (2), p.403-414</ispartof><rights>Society for Industrial Microbiology and Biotechnology 2013</rights><rights>Society for Industrial Microbiology and Biotechnology 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-1130661b90daf941fa7fea2f693077dd1547f2b832233db973bb37edcc84c35b3</citedby><cites>FETCH-LOGICAL-c551t-1130661b90daf941fa7fea2f693077dd1547f2b832233db973bb37edcc84c35b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10295-013-1349-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10295-013-1349-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24127067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ochi, Kozo</creatorcontrib><creatorcontrib>Tanaka, Yukinori</creatorcontrib><creatorcontrib>Tojo, Shigeo</creatorcontrib><title>Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements</title><title>Journal of industrial microbiology & biotechnology</title><addtitle>J Ind Microbiol Biotechnol</addtitle><addtitle>J Ind Microbiol Biotechnol</addtitle><description>Since bacteria were found to contain genes encoding enzymes that synthesize a plethora of potential secondary metabolites, interest has grown in the activation of these cryptic pathways. Homologous and heterologous expression of these cryptic secondary metabolite-biosynthetic genes, often “silent” under ordinary laboratory fermentation conditions, may lead to the discovery of novel secondary metabolites. We review current progress on this topic, describing concepts for activating silent genes. We especially focus on genetic manipulation of transcription and translation, as well as the utilization of rare earth elements as a novel method to activate the silent genes. The possible roles of silent genes in bacterial physiology are also discussed.</description><subject>Analysis</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Bacteria - genetics</subject><subject>Bacteria - metabolism</subject><subject>Bacterial physiology</subject><subject>Biochemistry</subject><subject>Bioinformatics</subject><subject>Biomedical and Life Sciences</subject><subject>Biosynthesis</subject><subject>Biotechnology</subject><subject>Carbon</subject><subject>DNA-Directed RNA Polymerases - genetics</subject><subject>DNA-Directed RNA Polymerases - metabolism</subject><subject>Enzymes</subject><subject>Fatty acids</subject><subject>Fermentation</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Gene Silencing</subject><subject>Genes</subject><subject>Genetic Engineering</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Inorganic Chemistry</subject><subject>Life Sciences</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metals, Rare Earth - pharmacology</subject><subject>Methods</subject><subject>Microbiology</subject><subject>Mutation</subject><subject>Natural products</subject><subject>Organic chemicals</subject><subject>Proteins</subject><subject>Rare earth elements</subject><subject>Review</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA polymerase</subject><subject>Secondary Metabolism - genetics</subject><subject>Secondary metabolites</subject><subject>Studies</subject><subject>Trace elements</subject><subject>Transcriptional Activation</subject><subject>Vegetable oils</subject><issn>1367-5435</issn><issn>1476-5535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc2KFDEUhYMozjj6AG4k4MZNaf5TWbaDfzAoiK5DkrrVU0NVUiapwX570_YoIgiuciHfOZfLh9BTSl5SQvSrQgkzsiOUd5QL04l76JwKrTopubzfZq50JwWXZ-hRKTeEEKk1e4jOmKBME6XPUd6FOt26OsU9rteA4fuaoZQpRZxG7F2okCc345APa50C3kOEgv0B5zW9xstWWzTFgqeIP3_c4TXNhwWyK4BT_om53EpdrtcYZlgg1vIYPRjdXODJ3XuBvr598-XyfXf16d2Hy91VF6SktaOUE6WoN2RwoxF0dHoEx0ZlONF6GKgUemS-54xxPnijufdcwxBCLwKXnl-gF6feNadvG5Rql6kEmGcXIW3FUmFUb3olzP-glCjW90f0-V_oTdpybIccKaI4lZo3ip6okFMpGUa75mlx-WApsUd39uTONnf26M6Klnl217z5BYbfiV-yGsBOQGlfcQ_5j9X_bP0BO5Sj6w</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Ochi, Kozo</creator><creator>Tanaka, Yukinori</creator><creator>Tojo, Shigeo</creator><general>Springer Berlin Heidelberg</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope><scope>7TM</scope><scope>RC3</scope></search><sort><creationdate>20140201</creationdate><title>Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements</title><author>Ochi, Kozo ; Tanaka, Yukinori ; Tojo, Shigeo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-1130661b90daf941fa7fea2f693077dd1547f2b832233db973bb37edcc84c35b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analysis</topic><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Bacteria - genetics</topic><topic>Bacteria - metabolism</topic><topic>Bacterial physiology</topic><topic>Biochemistry</topic><topic>Bioinformatics</topic><topic>Biomedical and Life Sciences</topic><topic>Biosynthesis</topic><topic>Biotechnology</topic><topic>Carbon</topic><topic>DNA-Directed RNA Polymerases - genetics</topic><topic>DNA-Directed RNA Polymerases - metabolism</topic><topic>Enzymes</topic><topic>Fatty acids</topic><topic>Fermentation</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Bacterial</topic><topic>Gene Silencing</topic><topic>Genes</topic><topic>Genetic Engineering</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Inorganic Chemistry</topic><topic>Life Sciences</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metals, Rare Earth - pharmacology</topic><topic>Methods</topic><topic>Microbiology</topic><topic>Mutation</topic><topic>Natural products</topic><topic>Organic chemicals</topic><topic>Proteins</topic><topic>Rare earth elements</topic><topic>Review</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA polymerase</topic><topic>Secondary Metabolism - 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Homologous and heterologous expression of these cryptic secondary metabolite-biosynthetic genes, often “silent” under ordinary laboratory fermentation conditions, may lead to the discovery of novel secondary metabolites. We review current progress on this topic, describing concepts for activating silent genes. We especially focus on genetic manipulation of transcription and translation, as well as the utilization of rare earth elements as a novel method to activate the silent genes. The possible roles of silent genes in bacterial physiology are also discussed.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24127067</pmid><doi>10.1007/s10295-013-1349-4</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of industrial microbiology & biotechnology, 2014-02, Vol.41 (2), p.403-414 |
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| subjects | Analysis Antibiotics Bacteria Bacteria - genetics Bacteria - metabolism Bacterial physiology Biochemistry Bioinformatics Biomedical and Life Sciences Biosynthesis Biotechnology Carbon DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Enzymes Fatty acids Fermentation Gene expression Gene Expression Regulation, Bacterial Gene Silencing Genes Genetic Engineering Genomes Genomics Inorganic Chemistry Life Sciences Metabolism Metabolites Metals, Rare Earth - pharmacology Methods Microbiology Mutation Natural products Organic chemicals Proteins Rare earth elements Review Ribonucleic acid RNA RNA polymerase Secondary Metabolism - genetics Secondary metabolites Studies Trace elements Transcriptional Activation Vegetable oils |
| title | Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements |
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