Anti-inflammatory and anti-arthritic effects of 3-hydroxy, 2-methoxy sodium butanoate from the leaves of Clerodendrum phlomidis L.f
Introduction The leaves of Clerodendrum phlomidis L.f. have been used in the Indian traditional system of medicine to treat several inflammatory diseases and arthritis. The aim of the present study was to assess the anti-inflammatory and anti-arthritic activities of the leaves of C. phlomidis and to...
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| Veröffentlicht in: | Inflammation research 2014-02, Vol.63 (2), p.127-138 |
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| creator | Prakash Babu, N. Saravanan, S. Pandikumar, P. Bala Krishna, K. Karunai Raj, M. Ignacimuthu, S. |
| description | Introduction
The leaves of
Clerodendrum
phlomidis
L.f. have been used in the Indian traditional system of medicine to treat several inflammatory diseases and arthritis. The aim of the present study was to assess the anti-inflammatory and anti-arthritic activities of the leaves of
C.
phlomidis
and to isolate the active principle by bioactivity guided fractionation.
Materials and methods
To find the anti-inflammatory constituents from this plant, fractionations were performed with concurrent bioassays. Carrageenan-induced inflammation and Freund complete adjuvant (FCA)-induced arthritic rat models were used. The anti-inflammatory and anti-arthritic activities of the isolated compound were studied by assessing the histology of the joints, levels of lysosomal enzymes, protein-bound carbohydrates, acute phase protein, etc., in plasma, as well as by estimating the levels and expression of pro-inflammatory cytokines in the joints.
Results
Repeated fractionations and bioassays yielded a novel bioactive compound: 3-hydroxy, 2-methoxy-sodium butanoate. Treatment with this compound reduced the paw edema induced by carrageenan and FCA dose dependently. The levels of lysosomal enzymes and protein-bound carbohydrates decreased significantly upon treatment with the compound. The level of plasma acute phase protein was also decreased compared with control animals. Protein levels and mRNA expression of pro-inflammatory cytokines TNF, IL-1 and IL-6 in the joints were decreased significantly in a dose-dependent manner and the histopathological data also added evidence of the anti-arthritic property of the compound.
Conclusion
The 3-hydroxy,2-methoxy sodium butanoate isolated from plant leaves displays considerable potency in anti-inflammatory action and has a prominent anti-arthritic effect. This is the first report of this natural compound with bioactivity. |
| doi_str_mv | 10.1007/s00011-013-0681-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1496897909</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3183757041</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-a48688498bce8a896ecab76a08fa67e6ce686f1f679a2bf78182e9a06f6ea4ce3</originalsourceid><addsrcrecordid>eNp1kUtrFTEYhoMo9qI_wI0E3LhoapKZk8uyHLzBgW4suAuZzBcnZTI5JhnxrP3jpj1VROgi5CN53jeBB6FXjF4ySuW7QilljFDWESoUI5sn6JT1nBJN1denbaa8I53q6Ak6K-W20Yor_hyd8AZxweQp-nW11EDC4mcbo60pH7Bdxrbaqc11yqEGh8F7cLXg5HFHpsOY08_DBeYkQp3aiEsawxrxsFa7JFsB-5wirhPgGewPuA9uZ8hphGXMjdxPc4phDAXvLv0L9MzbucDLh_0c3Xx4_2X7ieyuP37eXu2I6-mmEtsroVSv1eBAWaUFODtIYanyVkgQDoQSnnkhteWDl4opDtpS4QXY3kF3jt4ee_c5fV-hVBNDcTDPdoG0FsN6LZSWmuqGvvkPvU1rXtrvGiWlZpwy0Sh2pFxOpWTwZp9DtPlgGDV3hszRkGmGzJ0hs2mZ1w_N6xBh_Jv4o6QB_AiUdrV8g_zP04-2_gZ2nJzb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1477912016</pqid></control><display><type>article</type><title>Anti-inflammatory and anti-arthritic effects of 3-hydroxy, 2-methoxy sodium butanoate from the leaves of Clerodendrum phlomidis L.f</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Prakash Babu, N. ; Saravanan, S. ; Pandikumar, P. ; Bala Krishna, K. ; Karunai Raj, M. ; Ignacimuthu, S.</creator><creatorcontrib>Prakash Babu, N. ; Saravanan, S. ; Pandikumar, P. ; Bala Krishna, K. ; Karunai Raj, M. ; Ignacimuthu, S.</creatorcontrib><description>Introduction
The leaves of
Clerodendrum
phlomidis
L.f. have been used in the Indian traditional system of medicine to treat several inflammatory diseases and arthritis. The aim of the present study was to assess the anti-inflammatory and anti-arthritic activities of the leaves of
C.
phlomidis
and to isolate the active principle by bioactivity guided fractionation.
Materials and methods
To find the anti-inflammatory constituents from this plant, fractionations were performed with concurrent bioassays. Carrageenan-induced inflammation and Freund complete adjuvant (FCA)-induced arthritic rat models were used. The anti-inflammatory and anti-arthritic activities of the isolated compound were studied by assessing the histology of the joints, levels of lysosomal enzymes, protein-bound carbohydrates, acute phase protein, etc., in plasma, as well as by estimating the levels and expression of pro-inflammatory cytokines in the joints.
Results
Repeated fractionations and bioassays yielded a novel bioactive compound: 3-hydroxy, 2-methoxy-sodium butanoate. Treatment with this compound reduced the paw edema induced by carrageenan and FCA dose dependently. The levels of lysosomal enzymes and protein-bound carbohydrates decreased significantly upon treatment with the compound. The level of plasma acute phase protein was also decreased compared with control animals. Protein levels and mRNA expression of pro-inflammatory cytokines TNF, IL-1 and IL-6 in the joints were decreased significantly in a dose-dependent manner and the histopathological data also added evidence of the anti-arthritic property of the compound.
Conclusion
The 3-hydroxy,2-methoxy sodium butanoate isolated from plant leaves displays considerable potency in anti-inflammatory action and has a prominent anti-arthritic effect. This is the first report of this natural compound with bioactivity.</description><identifier>ISSN: 1023-3830</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/s00011-013-0681-5</identifier><identifier>PMID: 24202617</identifier><language>eng</language><publisher>Basel: Springer Basel</publisher><subject>Allergology ; Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Arthritis, Experimental - drug therapy ; Arthritis, Experimental - immunology ; Arthritis, Experimental - pathology ; Biomedical and Life Sciences ; Biomedicine ; Butyrates - pharmacology ; Butyrates - therapeutic use ; Carrageenan ; Clerodendrum ; Cytokines - genetics ; Cytokines - immunology ; Dermatology ; Edema - chemically induced ; Edema - drug therapy ; Edema - immunology ; Edema - pathology ; Female ; Foot Joints - immunology ; Foot Joints - pathology ; Immunology ; India ; Medicine, East Asian Traditional ; Neurology ; Neutrophils - immunology ; Original Research Paper ; Peroxidase - immunology ; Pharmacology/Toxicology ; Phytotherapy ; Plant Extracts - chemistry ; Plant Leaves - chemistry ; Rats ; Rats, Wistar ; Reactive Oxygen Species - immunology ; Rheumatology ; RNA, Messenger - metabolism</subject><ispartof>Inflammation research, 2014-02, Vol.63 (2), p.127-138</ispartof><rights>Springer Basel 2013</rights><rights>Springer Basel 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-a48688498bce8a896ecab76a08fa67e6ce686f1f679a2bf78182e9a06f6ea4ce3</citedby><cites>FETCH-LOGICAL-c405t-a48688498bce8a896ecab76a08fa67e6ce686f1f679a2bf78182e9a06f6ea4ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00011-013-0681-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00011-013-0681-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24202617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prakash Babu, N.</creatorcontrib><creatorcontrib>Saravanan, S.</creatorcontrib><creatorcontrib>Pandikumar, P.</creatorcontrib><creatorcontrib>Bala Krishna, K.</creatorcontrib><creatorcontrib>Karunai Raj, M.</creatorcontrib><creatorcontrib>Ignacimuthu, S.</creatorcontrib><title>Anti-inflammatory and anti-arthritic effects of 3-hydroxy, 2-methoxy sodium butanoate from the leaves of Clerodendrum phlomidis L.f</title><title>Inflammation research</title><addtitle>Inflamm. Res</addtitle><addtitle>Inflamm Res</addtitle><description>Introduction
The leaves of
Clerodendrum
phlomidis
L.f. have been used in the Indian traditional system of medicine to treat several inflammatory diseases and arthritis. The aim of the present study was to assess the anti-inflammatory and anti-arthritic activities of the leaves of
C.
phlomidis
and to isolate the active principle by bioactivity guided fractionation.
Materials and methods
To find the anti-inflammatory constituents from this plant, fractionations were performed with concurrent bioassays. Carrageenan-induced inflammation and Freund complete adjuvant (FCA)-induced arthritic rat models were used. The anti-inflammatory and anti-arthritic activities of the isolated compound were studied by assessing the histology of the joints, levels of lysosomal enzymes, protein-bound carbohydrates, acute phase protein, etc., in plasma, as well as by estimating the levels and expression of pro-inflammatory cytokines in the joints.
Results
Repeated fractionations and bioassays yielded a novel bioactive compound: 3-hydroxy, 2-methoxy-sodium butanoate. Treatment with this compound reduced the paw edema induced by carrageenan and FCA dose dependently. The levels of lysosomal enzymes and protein-bound carbohydrates decreased significantly upon treatment with the compound. The level of plasma acute phase protein was also decreased compared with control animals. Protein levels and mRNA expression of pro-inflammatory cytokines TNF, IL-1 and IL-6 in the joints were decreased significantly in a dose-dependent manner and the histopathological data also added evidence of the anti-arthritic property of the compound.
Conclusion
The 3-hydroxy,2-methoxy sodium butanoate isolated from plant leaves displays considerable potency in anti-inflammatory action and has a prominent anti-arthritic effect. This is the first report of this natural compound with bioactivity.</description><subject>Allergology</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Arthritis, Experimental - drug therapy</subject><subject>Arthritis, Experimental - immunology</subject><subject>Arthritis, Experimental - pathology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Butyrates - pharmacology</subject><subject>Butyrates - therapeutic use</subject><subject>Carrageenan</subject><subject>Clerodendrum</subject><subject>Cytokines - genetics</subject><subject>Cytokines - immunology</subject><subject>Dermatology</subject><subject>Edema - chemically induced</subject><subject>Edema - drug therapy</subject><subject>Edema - immunology</subject><subject>Edema - pathology</subject><subject>Female</subject><subject>Foot Joints - immunology</subject><subject>Foot Joints - pathology</subject><subject>Immunology</subject><subject>India</subject><subject>Medicine, East Asian Traditional</subject><subject>Neurology</subject><subject>Neutrophils - immunology</subject><subject>Original Research Paper</subject><subject>Peroxidase - immunology</subject><subject>Pharmacology/Toxicology</subject><subject>Phytotherapy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Leaves - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive Oxygen Species - immunology</subject><subject>Rheumatology</subject><subject>RNA, Messenger - metabolism</subject><issn>1023-3830</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtrFTEYhoMo9qI_wI0E3LhoapKZk8uyHLzBgW4suAuZzBcnZTI5JhnxrP3jpj1VROgi5CN53jeBB6FXjF4ySuW7QilljFDWESoUI5sn6JT1nBJN1denbaa8I53q6Ak6K-W20Yor_hyd8AZxweQp-nW11EDC4mcbo60pH7Bdxrbaqc11yqEGh8F7cLXg5HFHpsOY08_DBeYkQp3aiEsawxrxsFa7JFsB-5wirhPgGewPuA9uZ8hphGXMjdxPc4phDAXvLv0L9MzbucDLh_0c3Xx4_2X7ieyuP37eXu2I6-mmEtsroVSv1eBAWaUFODtIYanyVkgQDoQSnnkhteWDl4opDtpS4QXY3kF3jt4ee_c5fV-hVBNDcTDPdoG0FsN6LZSWmuqGvvkPvU1rXtrvGiWlZpwy0Sh2pFxOpWTwZp9DtPlgGDV3hszRkGmGzJ0hs2mZ1w_N6xBh_Jv4o6QB_AiUdrV8g_zP04-2_gZ2nJzb</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Prakash Babu, N.</creator><creator>Saravanan, S.</creator><creator>Pandikumar, P.</creator><creator>Bala Krishna, K.</creator><creator>Karunai Raj, M.</creator><creator>Ignacimuthu, S.</creator><general>Springer Basel</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20140201</creationdate><title>Anti-inflammatory and anti-arthritic effects of 3-hydroxy, 2-methoxy sodium butanoate from the leaves of Clerodendrum phlomidis L.f</title><author>Prakash Babu, N. ; Saravanan, S. ; Pandikumar, P. ; Bala Krishna, K. ; Karunai Raj, M. ; Ignacimuthu, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-a48688498bce8a896ecab76a08fa67e6ce686f1f679a2bf78182e9a06f6ea4ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Allergology</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Arthritis, Experimental - drug therapy</topic><topic>Arthritis, Experimental - immunology</topic><topic>Arthritis, Experimental - pathology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Butyrates - pharmacology</topic><topic>Butyrates - therapeutic use</topic><topic>Carrageenan</topic><topic>Clerodendrum</topic><topic>Cytokines - genetics</topic><topic>Cytokines - immunology</topic><topic>Dermatology</topic><topic>Edema - chemically induced</topic><topic>Edema - drug therapy</topic><topic>Edema - immunology</topic><topic>Edema - pathology</topic><topic>Female</topic><topic>Foot Joints - immunology</topic><topic>Foot Joints - pathology</topic><topic>Immunology</topic><topic>India</topic><topic>Medicine, East Asian Traditional</topic><topic>Neurology</topic><topic>Neutrophils - immunology</topic><topic>Original Research Paper</topic><topic>Peroxidase - immunology</topic><topic>Pharmacology/Toxicology</topic><topic>Phytotherapy</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Leaves - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reactive Oxygen Species - immunology</topic><topic>Rheumatology</topic><topic>RNA, Messenger - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prakash Babu, N.</creatorcontrib><creatorcontrib>Saravanan, S.</creatorcontrib><creatorcontrib>Pandikumar, P.</creatorcontrib><creatorcontrib>Bala Krishna, K.</creatorcontrib><creatorcontrib>Karunai Raj, M.</creatorcontrib><creatorcontrib>Ignacimuthu, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Inflammation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prakash Babu, N.</au><au>Saravanan, S.</au><au>Pandikumar, P.</au><au>Bala Krishna, K.</au><au>Karunai Raj, M.</au><au>Ignacimuthu, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory and anti-arthritic effects of 3-hydroxy, 2-methoxy sodium butanoate from the leaves of Clerodendrum phlomidis L.f</atitle><jtitle>Inflammation research</jtitle><stitle>Inflamm. Res</stitle><addtitle>Inflamm Res</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>63</volume><issue>2</issue><spage>127</spage><epage>138</epage><pages>127-138</pages><issn>1023-3830</issn><eissn>1420-908X</eissn><abstract>Introduction
The leaves of
Clerodendrum
phlomidis
L.f. have been used in the Indian traditional system of medicine to treat several inflammatory diseases and arthritis. The aim of the present study was to assess the anti-inflammatory and anti-arthritic activities of the leaves of
C.
phlomidis
and to isolate the active principle by bioactivity guided fractionation.
Materials and methods
To find the anti-inflammatory constituents from this plant, fractionations were performed with concurrent bioassays. Carrageenan-induced inflammation and Freund complete adjuvant (FCA)-induced arthritic rat models were used. The anti-inflammatory and anti-arthritic activities of the isolated compound were studied by assessing the histology of the joints, levels of lysosomal enzymes, protein-bound carbohydrates, acute phase protein, etc., in plasma, as well as by estimating the levels and expression of pro-inflammatory cytokines in the joints.
Results
Repeated fractionations and bioassays yielded a novel bioactive compound: 3-hydroxy, 2-methoxy-sodium butanoate. Treatment with this compound reduced the paw edema induced by carrageenan and FCA dose dependently. The levels of lysosomal enzymes and protein-bound carbohydrates decreased significantly upon treatment with the compound. The level of plasma acute phase protein was also decreased compared with control animals. Protein levels and mRNA expression of pro-inflammatory cytokines TNF, IL-1 and IL-6 in the joints were decreased significantly in a dose-dependent manner and the histopathological data also added evidence of the anti-arthritic property of the compound.
Conclusion
The 3-hydroxy,2-methoxy sodium butanoate isolated from plant leaves displays considerable potency in anti-inflammatory action and has a prominent anti-arthritic effect. This is the first report of this natural compound with bioactivity.</abstract><cop>Basel</cop><pub>Springer Basel</pub><pmid>24202617</pmid><doi>10.1007/s00011-013-0681-5</doi><tpages>12</tpages></addata></record> |
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| ispartof | Inflammation research, 2014-02, Vol.63 (2), p.127-138 |
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| subjects | Allergology Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Arthritis, Experimental - drug therapy Arthritis, Experimental - immunology Arthritis, Experimental - pathology Biomedical and Life Sciences Biomedicine Butyrates - pharmacology Butyrates - therapeutic use Carrageenan Clerodendrum Cytokines - genetics Cytokines - immunology Dermatology Edema - chemically induced Edema - drug therapy Edema - immunology Edema - pathology Female Foot Joints - immunology Foot Joints - pathology Immunology India Medicine, East Asian Traditional Neurology Neutrophils - immunology Original Research Paper Peroxidase - immunology Pharmacology/Toxicology Phytotherapy Plant Extracts - chemistry Plant Leaves - chemistry Rats Rats, Wistar Reactive Oxygen Species - immunology Rheumatology RNA, Messenger - metabolism |
| title | Anti-inflammatory and anti-arthritic effects of 3-hydroxy, 2-methoxy sodium butanoate from the leaves of Clerodendrum phlomidis L.f |
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